Irbesartan and Hydrochlorothiazide

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Overview

What is Irbesartan and Hydrochlorothiazide?

Irbesartan and hydrochlorothiazide tablets, USP are a combination of an angiotensin II receptor antagonist (AT subtype), irbesartan, and a thiazide diuretic, hydrochlorothiazide. Irbesartan is a non-peptide compound, chemically described as a 2-butyl-3-[-(-1-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one. Its molecular formula is CHNO, and its structural formula is:

Irbesartan USP is a white to off-white, crystalline powder with a molecular weight of 428.5. It is a nonpolar compound with a partition coefficient (octanol/water) of 10.1 at pH of 7.4. Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water. Hydrochlorothiazide is 6-chloro-3,4-dihydro-2-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its molecular formula is CHClNOS and its structural formula is:

Hydrochlorothiazide USP is a white or practically white, crystalline powder with a molecular weight of 297.7. Hydrochlorothiazide is slightly soluble in water and freely soluble in sodium hydroxide solution. Irbesartan and hydrochlorothiazide, USP is available for oral administration in film-coated tablets containing either 150 mg or 300 mg of irbesartan USP combined with 12.5 mg of hydrochlorothiazide USP or 300 mg of irbesartan USP combined with 25 mg of hydrochlorothiazide USP. Inactive ingredients include: colloidal silicon dioxide, hypromellose, iron oxide red, lactose monohydrate, polyethylene glycol, povidone, sodium stearyl fumarate, sodium starch glycolate, talc, and titanium dioxide. In addition 150 mg/12.5 mg, 300 mg/12.5 mg contains iron oxide yellow and 300 mg/25 mg contains iron oxide black.

What does Irbesartan and Hydrochlorothiazide look like?

What are the available doses of Irbesartan and Hydrochlorothiazide?

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What should I talk to my health care provider before I take Irbesartan and Hydrochlorothiazide?

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How should I use Irbesartan and Hydrochlorothiazide?

The side effects of irbesartan are generally rare and apparently independent of dose; those of hydrochlorothiazide are a mixture of dose-dependent (primarily hypokalemia) and dose-independent phenomena (e.g., pancreatitis), the former much more common than the latter . Maximum antihypertensive effects are attained within 2 to 4 weeks after a change in dose. Irbesartan and hydrochlorothiazide tablets may be administered with or without food. Irbesartan and hydrochlorothiazide tablets may be administered with other antihypertensive agents.The usual regimens of therapy with irbesartan and hydrochlorothiazide tablets may be followed as long as the patient’s creatinine clearance is >30 mL/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so irbesartan and hydrochlorothiazide tablets are not recommended. No dosage adjustment is necessary in patients with hepatic impairment.

What interacts with Irbesartan and Hydrochlorothiazide?

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What are the warnings of Irbesartan and Hydrochlorothiazide?

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What are the precautions of Irbesartan and Hydrochlorothiazide?

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What are the side effects of Irbesartan and Hydrochlorothiazide?

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What should I look out for while using Irbesartan and Hydrochlorothiazide?

What might happen if I take too much Irbesartan and Hydrochlorothiazide?

Irbesartan

Physicians’ Desk Reference

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How should I store and handle Irbesartan and Hydrochlorothiazide?

Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST: Ketoconazole Tablets, USP are available containing 200 mg of ketoconazole, USP. The 200 mg tablets are white to off-white round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows: NDC 0378-0261-01 bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep out of reach of children.PHARMACIST:

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology

Ketoconazole is mainly metabolized through CYP3A4. Other substances that either sharethis metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of ketoconazole. Similarly, ketoconazole may modify the pharmacokinetics of other substances that share this metabolic pathway. Ketoconazole is a potent CYP3A4 inhibitor and a P-glycoprotein inhibitor. When using concomitant medication, the corresponding label should be consulted for information on the route of metabolism and the possible need to adjust dosages.

Interaction studies have only been performed in adults. The relevance of the results from these studies in pediatric patients is unknown.

Pregnancy Category D

deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension,

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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