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Jardiance

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Overview

What is Jardiance?

JARDIANCE tablets contain empagliflozin, an orally-active inhibitor of the sodium-glucose co-transporter 2 (SGLT2).

The chemical name of empagliflozin is D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1S).

Its molecular formula is CHClO and the molecular weight is 450.91. The structural formula is:

Empagliflozin is a white to yellowish, non-hygroscopic powder.  It is very slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol and acetonitrile; soluble in 50% acetonitrile/water; and practically insoluble in toluene.

Each film-coated tablet of JARDIANCE contains 10 mg or 25 mg of empagliflozin (free base) and the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, colloidal silicon dioxide and magnesium stearate.  In addition, the film coating contains the following inactive ingredients: hypromellose, titanium dioxide, talc, polyethylene glycol, and yellow ferric oxide.



What does Jardiance look like?



What are the available doses of Jardiance?

Tablets: 10 mg, 25 mg ()

What should I talk to my health care provider before I take Jardiance?

How should I use Jardiance?

JARDIANCE is indicated:                 

Limitations of Use

The recommended dose of JARDIANCE is 10 mg once daily in the morning, taken with or without food.  In patients tolerating JARDIANCE, the dose may be increased to 25 mg .

In patients with volume depletion, correcting this condition prior to initiation of JARDIANCE is recommended


What interacts with Jardiance?

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What are the warnings of Jardiance?

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What are the precautions of Jardiance?

Sorry No Records found


What are the side effects of Jardiance?

Sorry No records found


What should I look out for while using Jardiance?

History of serious hypersensitivity reaction to empagliflozin or any of the excipients in JARDIANCE ()

Severe renal impairment, end-stage renal disease, or dialysis ()


What might happen if I take too much Jardiance?

In the event of an overdose with JARDIANCE, contact the Poison Control Center.  Employ the usual supportive measures (e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive treatment) as dictated by the patient’s clinical status.  Removal of empagliflozin by hemodialysis has not been studied.


How should I store and handle Jardiance?

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)JARDIANCE tablets are available in 10 mg and 25 mg strengths as follows:10 mg tablets:25 mg tablets:Dispense in a well-closed container as defined in the USP.StorageStore at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F)


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Sodium-glucose co-transporter 2 (SGLT2) is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation.  Empagliflozin is an inhibitor of SGLT2.  By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion.

Non-Clinical Toxicology
History of serious hypersensitivity reaction to empagliflozin or any of the excipients in JARDIANCE ()

Severe renal impairment, end-stage renal disease, or dialysis ()

JARDIANCE causes intravascular volume contraction.  Symptomatic hypotension may occur after initiating JARDIANCE particularly in patients with renal impairment, the elderly, in patients with low systolic blood pressure, and in patients on diuretics.  Before initiating JARDIANCE, assess for volume contraction and correct volume status if indicated.  Monitor for signs and symptoms of hypotension after initiating therapy and increase monitoring in clinical situations where volume contraction is expected .

The following important adverse reactions are described below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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