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Tobramycin

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Overview

What is Kitabis Pak?

KITABIS PAK contains tobramycin inhalation solution, USP and the PARI LC PLUS Reusable Nebulizer (PARI LC PLUS). Tobramycin inhalation solution is a sterile, clear, slightly yellow, non-pyrogenic, aqueous solution with the pH and salinity adjusted specifically for administration by a compressed air driven PARI LC PLUS Reusable Nebulizer. The chemical formula for tobramycin is C H N O and the molecular weight is 467.52. Tobramycin is O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D- -hexopyranosyl-(1→6)]-2-deoxy-L-streptamine. The structural formula for tobramycin is:

Each single-use 5 mL ampule contains 300 mg tobramycin and 11.25 mg sodium chloride in sterile water for injection. Sulfuric acid and sodium hydroxide are added to adjust the pH to 6.0. Nitrogen is used for sparging. The formulation contains no preservatives. The inhalation solution has an osmolality in the range 135 to 200 mOsmol/kg.

The PARI LC PLUS Reusable Nebulizer has the following performance characteristics with tobramycin inhalation solution [measured using Next Generation Impactor (NGI) at 15L/min continuous flow, standard conditions (50%RH, 23ºC)]: (1) Delivered Dose: 174 mg; (2) Fine Particle Dose (<5μm): 97 mg; (3) Nebulization Time: 13 min.; (4) Mass Median Aerodynamic Diameter: 4.3 μm; (5) Geometric Standard Deviation (GSD): 2.2 μm.



What does Kitabis Pak look like?



What are the available doses of Kitabis Pak?

Inhalation solution: 300 mg/5mL in a single-use ampule

What should I talk to my health care provider before I take Kitabis Pak?

How should I use Kitabis Pak?

KITABIS PAK (co-packaging of tobramycin inhalation solution and PARI LC PLUS Reusable Nebulizer) is indicated for the management of cystic fibrosis in adults and pediatric patients 6 years of age and older with Safety and efficacy have not been demonstrated in patients under the age of 6 years, patients with FEV <25% or >75% predicted, or patients colonized with

KITABIS PAK is a co-packaging of tobramycin inhalation solution with a PARI LC PLUS® Reusable Nebulizer ( ).

Administer tobramycin inhalation solution as one single–use ampule (300 mg/5 mL) twice a day by oral inhalation in alternating periods of 28 days on drug, followed by 28 days off drug ( ).

Dosage is not adjusted by weight ( ).

Take doses as close to 12 hours apart as possible; but not less than 6 hours apart ( )

Administer each 300 mg dose using the PARI LC PLUS Reusable Nebulizer and DeVilbiss® PulmoAide® compressor ( )


What interacts with Kitabis Pak?

Sorry No Records found


What are the warnings of Kitabis Pak?

Sorry No Records found


What are the precautions of Kitabis Pak?

Sorry No Records found


What are the side effects of Kitabis Pak?

Sorry No records found


What should I look out for while using Kitabis Pak?

Tobramycin inhalation solution is contraindicated in patients with a known hypersensitivity to any aminoglycoside.


What might happen if I take too much Kitabis Pak?

Signs and symptoms of acute toxicity from overdosage of IV tobramycin might include dizziness, tinnitus, vertigo, loss of high-tone hearing acuity, respiratory failure, and neuromuscular blockade. Administration by inhalation results in low systemic bioavailability of tobramycin. Tobramycin is not significantly absorbed following oral administration. Tobramycin serum concentrations may be helpful in monitoring overdosage.


How should I store and handle Kitabis Pak?

Penicillin V Potassium Tablets USP, 250 mg (400,000 units)


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Tobramycin is an antibacterial drug

Non-Clinical Toxicology
Tobramycin inhalation solution is contraindicated in patients with a known hypersensitivity to any aminoglycoside.

Methylphenidate hydrochloride should not be used in patients being treated (currently or within the proceeding two weeks) with MAO Inhibitors (see , Monoamine Oxidase Inhibitors). Because of possible effects on blood pressure, methylphenidate hydrochloride should be used cautiously with pressor agents.

Methylphenidate may decrease the effectiveness of drugs used to treat hypertension. Methylphenidate is metabolized primarily to ritalinic acid by de-esterification and not through oxidative pathways.

Human pharmacologic studies have shown that racemic methylphenidate may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (e.g., phenobarbital, phenytoin, primidone), and tricyclic drugs (e.g., imipramine, clomipramine, desipramine). Downward dose adjustments of these drugs may be required when given concomitantly with methylphenidate. It may be necessary to adjust the dosage and monitor plasma drug concentration (or, in case of coumarin, coagulation times), when initiating or discontinuing methylphenidate.

Bronchospasm can occur with inhalation of tobramycin inhalation solution. In clinical studies with tobramycin inhalation solution, changes in FEV measured after the inhaled dose were similar in tobramycin inhalation solution and placebo groups. Bronchospasm that occurs during the use of tobramycin inhalation solution should be treated as medically appropriate.

The following serious adverse reactions are described below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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