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Kristalose

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Overview

What is Kristalose?

KRISTALOSE (LACTULOSE) is a synthetic disaccharide in the form of crystals for reconstitution prior to use for oral administration. Each 10 g of lactulose contains less than 0.3 g galactose and lactose as a total sum. The pH range is 3.0 to 7.0.

Lactulose is a colonic acidifier which promotes laxation.

The chemical name for lactulose is 4-O-β-D-Galactopyranosyl-D-fructofuranose. It has the following structural formula:

The molecular formula is C H O . The molecular weight is 342.30. It is freely soluble in water.



What does Kristalose look like?



What are the available doses of Kristalose?

Sorry No records found.

What should I talk to my health care provider before I take Kristalose?

Sorry No records found

How should I use Kristalose?

KRISTALOSE (LACTULOSE) For Oral Solution is indicated for the treatment of constipation. In patients with a history of chronic constipation, lactulose therapy increases the number of bowel movements per day and the number of days on which bowel movements occur.

The usual adult dosage is 10 g to 20 g of lactulose daily. The dose may be increased to 40 g daily if necessary. Twenty-four to 48 hours may be required to produce a normal bowel movement.


What interacts with Kristalose?

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What are the warnings of Kristalose?

Sorry No Records found


What are the precautions of Kristalose?

Sorry No Records found


What are the side effects of Kristalose?

Sorry No records found


What should I look out for while using Kristalose?

Since KRISTALOSE (LACTULOSE) For Oral Solution contains galactose (less than 0.3 g/10 g as a total sum with lactose), it is contraindicated in patients who require a low galactose diet.

A theoretical hazard may exist for patients being treated with lactulose who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy. Accumulation of H gas in significant concentration in the presence of an electrical spark may result in an explosive reaction. Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution. Insufflation of CO as an additional safeguard may be pursued but is considered to be a redundant measure.


What might happen if I take too much Kristalose?


How should I store and handle Kristalose?

KRISTALOSE (LACTULOSE) For Oral Solution is available in single dose packets of 10 g (NDC 66220-719-01) and single dose packets of 20 g (NDC 66220-729-01). The packets are supplied as follows: STORE AT ROOM TEMPERATURE, 15°-30°C (59°-86°F).To report adverse events associated with this product, please call 1-877-484-2700. www.kristalose.com Manufactured for: CUMBERLAND PHARMACEUTICALS INC. Nashville, TN 37203 KPI 021201 KRISTALOSE (LACTULOSE) For Oral Solution is available in single dose packets of 10 g (NDC 66220-719-01) and single dose packets of 20 g (NDC 66220-729-01). The packets are supplied as follows: STORE AT ROOM TEMPERATURE, 15°-30°C (59°-86°F).To report adverse events associated with this product, please call 1-877-484-2700. www.kristalose.com Manufactured for: CUMBERLAND PHARMACEUTICALS INC. Nashville, TN 37203 KPI 021201 KRISTALOSE (LACTULOSE) For Oral Solution is available in single dose packets of 10 g (NDC 66220-719-01) and single dose packets of 20 g (NDC 66220-729-01). The packets are supplied as follows: STORE AT ROOM TEMPERATURE, 15°-30°C (59°-86°F).To report adverse events associated with this product, please call 1-877-484-2700. www.kristalose.com Manufactured for: CUMBERLAND PHARMACEUTICALS INC. Nashville, TN 37203 KPI 021201 KRISTALOSE (LACTULOSE) For Oral Solution is available in single dose packets of 10 g (NDC 66220-719-01) and single dose packets of 20 g (NDC 66220-729-01). The packets are supplied as follows: STORE AT ROOM TEMPERATURE, 15°-30°C (59°-86°F).To report adverse events associated with this product, please call 1-877-484-2700. www.kristalose.com Manufactured for: CUMBERLAND PHARMACEUTICALS INC. Nashville, TN 37203 KPI 021201 KRISTALOSE (LACTULOSE) For Oral Solution is available in single dose packets of 10 g (NDC 66220-719-01) and single dose packets of 20 g (NDC 66220-729-01). The packets are supplied as follows: STORE AT ROOM TEMPERATURE, 15°-30°C (59°-86°F).To report adverse events associated with this product, please call 1-877-484-2700. www.kristalose.com Manufactured for: CUMBERLAND PHARMACEUTICALS INC. Nashville, TN 37203 KPI 021201


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

KRISTALOSE (LACTULOSE) is poorly absorbed from the gastrointestinal tract and no enzyme capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue. As a result, oral doses of lactulose reach the colon virtually unchanged. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool.

Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce desired bowel movement.

Lactulose given orally to man and experimental animals resulted in only small amounts reaching the blood. Urinary excretion has been determined to be 3% or less and is essentially complete within 24 hours.

Non-Clinical Toxicology
Since KRISTALOSE (LACTULOSE) For Oral Solution contains galactose (less than 0.3 g/10 g as a total sum with lactose), it is contraindicated in patients who require a low galactose diet.

A theoretical hazard may exist for patients being treated with lactulose who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy. Accumulation of H gas in significant concentration in the presence of an electrical spark may result in an explosive reaction. Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution. Insufflation of CO as an additional safeguard may be pursued but is considered to be a redundant measure.

Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose.

Since KRISTALOSE (LACTULOSE) For Oral Solution contains galactose and lactose (less than 0.3 g/10 g as a total sum), it should be used with caution in diabetics.

Precise frequency data are not available.

Initial dosing may produce flatulence and intestinal cramps, which are usually transient. Excessive dosage can lead to diarrhea with potential complications such as loss of fluids, hypokalemia, and hypernatremia.

Nausea and vomiting have been reported.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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