Levorphanol Tartrate

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Overview

What is Levorphanol Tartrate?

Levorphanol Tartrate Tablets, contain levorphanol, an opioid agonist with a molecular formula of

CHNO • CHO • 2HO and molecular weight 443.5. Each milligram of levorphanol tartrate is equivalent to 0.58 mg levorphanol base. Levorphanol's chemical name is levo-3- hydroxy-Nmethylmorphinan. The USP nomenclature is 17- methylmorphinan 3-ol tartrate (1:1)(Salt) dihydrate. The material has 3 asymmetric carbon atoms. The chemical structure is:

Levorphanol tartrate is a white crystalline powder, soluble in water and ether, but insoluble in chloroform.

Each tablet, for oral administration, contains 2 mg levorphanol tartrate. In addition, each tablet contains anhydrous lactose, corn starch, and magnesium stearate.

What does Levorphanol Tartrate look like?

What are the available doses of Levorphanol Tartrate?

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What should I talk to my health care provider before I take Levorphanol Tartrate?

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How should I use Levorphanol Tartrate?

Levorphanol Tartrate Tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see ].

Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see ].

Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with Levorphanol Tartrate Tablets and adjust the dosage accordingly [see ].

What interacts with Levorphanol Tartrate?

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What are the warnings of Levorphanol Tartrate?

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What are the precautions of Levorphanol Tartrate?

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What are the side effects of Levorphanol Tartrate?

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What should I look out for while using Levorphanol Tartrate?

Levorphanol Tartrate Tablets are contraindicated in patients with:

What might happen if I take too much Levorphanol Tartrate?

How should I store and handle Levorphanol Tartrate?

Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1 Levorphanol Tartrate Tablets USP, 2 mg White, scored tablets (Identified 54 410).NDC: 42358-102-10 Bottles of 100 tablets. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.] Dispense in an amber airtight container as defined in the USP. Manufactured for: Sentynl Therapeutics, Inc. Solana Beach, CA 92075 Revised December 2016 LV20161201.1

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Levorphanol is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of levorphanol is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with levorphanol. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.

The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.

Non-Clinical Toxicology

Levorphanol Tartrate Tablets are contraindicated in patients with:

Advise the patient to read the FDA-approved patient labeling (Medication Guide).

In approximately 1400 patients treated with Levorphanol Tartrate Tablets in controlled clinical trials, the type and incidence of side effects were those expected of an opioid analgesic, and no unforeseen or unusual toxicity was reported.

Drugs of this type are expected to produce a cluster of typical opioid effects in addition to analgesia, consisting of nausea, vomiting, altered mood and mentation, pruritus, flushing, difficulties in urination, constipation, and biliary spasm. The frequency and intensity of these effects appears to be dose related. Although listed as adverse events these are expected pharmacologic actions of these drugs and should be interpreted as such by the clinician.

The following adverse events have been reported with the use of Levorphanol Tartrate Tablets: abdominal pain, dry mouth, sweating

Cardiovascular System:

Digestive System:

Nervous System:

hyperkinesia, CNS stimulation, personality disorder, amnesia, insomnia apnea, cyanosis, hypoventilation

Skin & Appendages:

Special Senses:

Urogenital System:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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