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Linezolid

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Overview

What is Linezolid?

Linezolid intravenous injection contains linezolid, which is a synthetic antibacterial agent of the oxazolidinone class. The chemical name for linezolid is (S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl]-acetamide.

The molecular formula is CHFNO. Its molecular weight is 337.35, and its chemical structure is represented below:

Linezolid intravenous injection is supplied as a ready-to-use sterile isotonic solution for intravenous infusion. Each mL contains 2 mg of linezolid. Inactive ingredients are citric acid anhydrous, dextrose in an aqueous vehicle for intravenous administration, and sodium citrate. The sodium (Na) content is 0.38 mg/mL (5 mEq per 300 mL bag and 1.7 mEq per 100 mL bag). The pH has been adjusted with sodium hydroxide and/or hydrochloric acid.



What does Linezolid look like?



What are the available doses of Linezolid?

Linezolid intravenous injection: 100 mL (200 mg linezolid) and 300 mL (600 mg linezolid) single-use, ready-to-use flexible plastic infusion bags in a foil laminate overwrap. The infusion bags and ports are latex-free.

What should I talk to my health care provider before I take Linezolid?

How should I use Linezolid?

Linezolid injection is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Linezolid injection is not indicated for the treatment of Gram-negative infections. It is critical that specific Gram-negative therapy be initiated immediately if a concomitant Gram-negative pathogen is documented or suspected

The recommended dosage for linezolid for the treatment of infections is described in .

Table 1. Dosage Guidelines for Linezolid

No dose adjustment is necessary when switching from intravenous to oral administration.


What interacts with Linezolid?

Sorry No Records found


What are the warnings of Linezolid?

Sorry No Records found


What are the precautions of Linezolid?

Sorry No Records found


What are the side effects of Linezolid?

Sorry No records found


What should I look out for while using Linezolid?



4.1

4.2


What might happen if I take too much Linezolid?

In the event of overdosage, supportive care is advised, with maintenance of glomerular filtration. Hemodialysis may facilitate more rapid elimination of linezolid. In a Phase 1 clinical trial, approximately 30% of a dose of linezolid was removed during a 3-hour hemodialysis session beginning 3 hours after the dose of linezolid was administered. Data are not available for removal of linezolid with peritoneal dialysis or hemoperfusion. Clinical signs of acute toxicity in animals were decreased activity and ataxia in rats and vomiting and tremors in dogs treated with 3000 mg/kg/day and 2000 mg/kg/day, respectively.


How should I store and handle Linezolid?

Store at 20° to 25°C (68° to 77°F). Protect from light. It is recommended that the infusion bags be kept in the overwrap until ready to use. Protect infusion bags from freezing.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “51” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-751-03Bottle of 100 Tablets:             NDC 65162-751-10Bottle of 500 Tablets:             NDC 65162-751-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “52” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-752-03Bottle of 100 Tablets:             NDC 65162-752-10Bottle of 500 Tablets:             NDC 65162-752-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “53” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-753-03Bottle of 100 Tablets:             NDC 65162-753-10Bottle of 500 Tablets:             NDC 65162-753-50Benazepril HCl tablets, USP, , are supplied as white, biconvex, round, uncoated tablets, debossed with “54” on one side and “A” on the other side.They are available as follows:Bottle of 30 Tablets:               NDC 65162-754-03Bottle of 100 Tablets:             NDC 65162-754-10Bottle of 500 Tablets:             NDC 65162-754-50Storage: Store at 20º to 25°C (68° to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature]. Protect from moisture.Dispense in a tight container as defined in the USP.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Linezolid injection is an antibacterial drug

Non-Clinical Toxicology


4.1

4.2

Nimodipine is metabolized via the cytochrome P450 3A4 system located both in the intestinal mucosa and in the liver. Drugs that are known to either inhibit or to induce this enzyme system may therefore alter the first pass or the clearance of nimodipine.

In addition, the blood pressure lowering effects of antihypertensives could be enhanced when taken concomitantly with nimodipine.

Inducers of CYP3A4

Nimodipine plasma concentration and efficacy may be significantly reduced when concomitantly administered with strong CYP3A4 inducers. Therefore strong CYP3A4 inducers (e.g. rifampin, carbamazepine, phenobarbital, phenytoin, St. John’s Wort) should generally not be administered concomitantly with nimodipine (See ).

Other moderate and weak inducers of CYP3A4 may also reduce the efficacy of nimodipine, although the magnitude of decrease in nimodipine plasma concentrations is not known. Patients on these should be closely monitored for lack of effectiveness, and a nimodipine dosage increase may be required. Moderate and weak CYP3A4 inducers include: amprenavir, aprepitant, armodafinil, bosentan, efavirenz, etravirine, Echinacea, modafinil, nafcillin, pioglitazone, prednisone and rufinamide.

Inhibitors of CYP3A4

Nimodipine plasma concentration can be significantly increased when concomitantly administered with strong inhibitors of the CYP3A4 system. As a consequence, the blood pressure lowering effect may be increased. Therefore strong CYP3A4 inhibitors should not be coadministered with nimodipine (See ). Strong CYP3A4 inhibitors include some members of the following classes:

Nimodipine plasma concentration can also be increased in the presence of moderate and weak inhibitors of CYP3A4. If nimodipine is concomitantly administered with these drugs, blood pressure should be monitored, and a reduction of the nimodipine dose may be necessary. Moderate and weak CYP3A4 inhibitors include amprenavir, aprepitant, atazanavir, amiodarone, alprozalam, cyclosporine, cimetidine, erythromycin, fluconazole, fluoxetine, isoniazid, oral contraceptives, quinuprestin/dalforpristin, and valproic acid.

Blood pressure lowering drugs

Nimodipine may increase the blood pressure lowering effect of concomitantly administered anti-hypertensives, such as:

Blood pressure should be carefully monitored, and dose adjustment of the blood pressure lowering drug(s) may be necessary.

Myelosuppression (including anemia, leukopenia, pancytopenia, and thrombocytopenia) has been reported in patients receiving linezolid. In cases where the outcome is known, when linezolid was discontinued, the affected hematologic parameters have risen toward pretreatment levels. Complete blood counts should be monitored weekly in patients who receive linezolid, particularly in those who receive linezolid for longer than two weeks, those with pre-existing myelosuppression, those receiving concomitant drugs that produce bone marrow suppression, or those with a chronic infection who have received previous or concomitant antibiotic therapy. Discontinuation of therapy with linezolid should be considered in patients who develop or have worsening myelosuppression

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).