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Livostin

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Overview

What is Livostin?

LIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension) is a selective histamine H-receptor antagonist for topical ophthalmic use. Each mL contains 0.54 mg levocabastine hydrochloride equivalent to 0.5 mg levocabastine; 0.15 mg benzalkonium chloride; propylene glycol; polysorbate 80; dibasic sodium phosphate, anhydrous; monobasic sodium phosphate, monohydrate; disodium edetate; hydroxypropyl methylcellulose; and purified water. It has a pH of 6.0 to 8.0.

The chemical name for levocabastine hydrochloride is (–)--1-[-4-Cyano-4- (p-fluorophenyl)cyclohexyl]-3-methyl-4-phenylisonipecotic acid monohydrochloride, and is represented by the following chemical structure:



What does Livostin look like?



What are the available doses of Livostin?

Sorry No records found.

What should I talk to my health care provider before I take Livostin?

Sorry No records found

How should I use Livostin?

Sorry No records found


What interacts with Livostin?

This product is contraindicated in persons with known or suspected hypersensitivity to any of its components. It should not be used while soft contact lenses are being worn.



What are the warnings of Livostin?

Sorry No Records found


What are the precautions of Livostin?

Information for Patients

SHAKE WELL BEFORE USING.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Levocabastine was not carcinogenic in male or female rats or in male mice when administered in the diet for up to 24 months. In female mice, levocabastine doses of 5,000 and 21,500 times the maximum recommended ocular human use level resulted in an increased incidence of pituitary gland adenoma and mammary gland adenocarcinoma possibly produced by increased prolactin levels. The clinical relevance of this finding is unknown with regard to the interspecies differences in prolactin physiology and the very low plasma concentrations of levocabastine following ocular administration.

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Mutagenic potential was not demonstrated for levocabastine when tested in Ames’ Salmonella reversion test or in a mouse Dominant Lethal Assay or in rat Micronucleus test.

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In reproduction studies in rats, levocabastine showed no effects on fertility at oral doses of 20 mg/kg/day (8,300 times the maximum recommended human ocular dose).


What are the side effects of Livostin?

The most frequent adverse experiences reported with the use of LIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension) were mild, transient stinging and burning (29%) and headache (5%).

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Other adverse experiences reported in approximately 1-3% of patients treated with LIVOSTIN™ were visual disturbances, dry mouth, fatigue, pharyngitis, eye pain/dryness, somnolence, red eyes, lacrimation/discharge, cough, nausea, rash/erythema, eyelid edema, and dyspnea.


What should I look out for while using Livostin?

This product is contraindicated in persons with known or suspected hypersensitivity to any of its components. It should not be used while soft contact lenses are being worn.


What might happen if I take too much Livostin?

Sorry No Records found


How should I store and handle Livostin?

LIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-ELIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension), 2.5 mL, 5 mL, and 10 mL is provided in white, polyethylene dropper tip squeeze bottles. Keep tightly closed when not in use.Do not use if the suspension has discolored.Store at controlled room temperature 15°to 30°C (59° to 86°F).Protect from freezing.NDC 58768-610-10 (10.0 mL)NDC 58768-610-05 (5.0 mL)NDC 58768-610-99 (2.5 mL)Rx OnlyLevocabastine hydrochloride is an original product of Janssen Pharmaceutica Inc.Mfd. by OMJ Pharmaceuticals, Inc., San Germán, P.R., 00683 for:Novartis Ophthalmics, Duluth, GA 300975035-E


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Levocabastine is a potent, selective histamine H-antagonist.

Antigen challenge studies performed two and four hours after initial drug instillation indicated activity was maintained for at least two hours.

In an environmental study, LIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension) instilled four times daily was shown to be significantly more effective than its vehicle in reducing ocular itching associated with seasonal allergic conjunctivitis.

After instillation in the eye, levocabastine is systemically absorbed. However, the amount of systemically absorbed levocabastine after therapeutic ocular doses is low (mean plasma concentrations in the range of 1-2 ng/mL).

Non-Clinical Toxicology
This product is contraindicated in persons with known or suspected hypersensitivity to any of its components. It should not be used while soft contact lenses are being worn.

There is evidence that the anticonvulsant action of phenytoin is antagonized by folic acid. A patient whose epilepsy is completely controlled by phenytoin may require increased doses to prevent convulsions if folic acid is given.

Folate deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g., folic acid antagonists such as methotrexate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially, alcoholic cirrhosis; and the administration of pyrimethamine and nitrofurantoin.

False low serum and red cell folate levels may occur if the patient has been taking antibiotics, such as tetracycline, which suppress the growth of

SHAKE WELL BEFORE USING.

The most frequent adverse experiences reported with the use of LIVOSTIN™ 0.05% (levocabastine hydrochloride ophthalmic suspension) were mild, transient stinging and burning (29%) and headache (5%).

Other adverse experiences reported in approximately 1-3% of patients treated with LIVOSTIN™ were visual disturbances, dry mouth, fatigue, pharyngitis, eye pain/dryness, somnolence, red eyes, lacrimation/discharge, cough, nausea, rash/erythema, eyelid edema, and dyspnea.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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