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chlorzoxazone
Overview
What is Lorzone?
Each 375 mg Lorzone tablet contains: chlorzoxazone USP 375 mg.
Each 750 mg Lorzone tablet contains: chlorzoxazone USP 750 mg.
Chemical Name: 5-Chloro-2-benzoxazolinone.
Structural Formula:
Molecular Formula: CHCINO
Molecular Weight: 169.56
Chlorzoxazone USP is a white or practically white, practically odorless, crystalline powder. Chlorzoxazone is slightly soluble in water; sparingly soluble in alcohol, in isopropyl alcohol, and in methanol; soluble in solutions of alkali hydroxides and ammonia.
Inactive ingredients: anhydrous lactose, croscarmellose sodium, docusate sodium, magnesium stearate, microcrystalline cellulose, pregelatinized corn starch and sodium benzoate.
What does Lorzone look like?
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What are the available doses of Lorzone?
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What should I talk to my health care provider before I take Lorzone?
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How should I use Lorzone?
Lorzone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.
Usual Adult Dosage
Lorzone
chlorzoxazone
USP) 375 mg:
One tablet three or four times daily. If adequate response is not obtained with this dose, the 375 mg tablets may be increased to two tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
Lorzone
chlorzoxazone
USP) 750 mg:
1/3 tablet (250 mg) three or four times daily. Initial dosage for painful musculoskeletal conditions should be 2/3 tablet (500 mg) three or four times daily. If adequate response is not obtained with this dose, it may be increased to one tablet (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
What interacts with Lorzone?
Lorzone is contraindicated in patients with known intolerance to the drug.
What are the warnings of Lorzone?
Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reported. Reports usually indicate that Furosemide tablets ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. If the physician elects to use high dose parenteral therapy, controlled intravenous infusion is advisable (for adults, an infusion rate not exceeding 4 mg Furosemide tablets per minute has been used). (See
Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/ or symptoms of hepatoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice. Lorzone should be discontinued immediately and a physician consulted if any of these signs or symptoms develop. Lorzone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphates and bilirubin).
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Usage in Pregnancy:
What are the precautions of Lorzone?
Lorzone should be used with caution in patients with known allergies or with a history of allergic reactions to drugs. If sensitivity reaction occurs such as urticaria, redness, or itching of the skin, the drug should be stopped.
If any symptoms suggestive of liver dysfunction are observed, the drug should be discontinued.
What are the side effects of Lorzone?
Chlorzoxazone-containing products are usually well tolerated. It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light- headedness, malaise, or overstimulation may be noted by an occasional patient. Rarely, allergic-type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare. There is no evidence that the drug will cause renal damage. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. This finding is of no known clinical significance.
What should I look out for while using Lorzone?
Lorzone is contraindicated in patients with known intolerance to the drug.
Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/ or symptoms of hepatoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice. Lorzone should be discontinued immediately and a physician consulted if any of these signs or symptoms develop. Lorzone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphates and bilirubin).
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Usage in Pregnancy:
What might happen if I take too much Lorzone?
Symptoms:
Treatment:
How should I store and handle Lorzone?
Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CII Narcotic.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CII Narcotic.Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.A Schedule CII Narcotic.Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Lorzone Tablets (chlorzoxazone USP) is supplied as follows:375 mg A white capsule shaped tablet, debossed “ADG” on one side and “375” on the other side.55700-517-30750 mgA white capsule shaped tablet, debossed “ADG” on the trisected side and “750” on the bisected side.Dispense in tight container as defined in the official compendium.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Blood levels of chlorzoxazone can be detected in people during the first 30 minutes and peak levels may be reached, in the majority of the subjects, in about 1 to 2 hours after oral administration of chlorzoxazone. Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. Less than one percent of a dose of chlorzoxazone is excreted unchanged in the urine in 24 hours.
Non-Clinical Toxicology
Lorzone is contraindicated in patients with known intolerance to the drug.Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/ or symptoms of hepatoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice. Lorzone should be discontinued immediately and a physician consulted if any of these signs or symptoms develop. Lorzone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphates and bilirubin).
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Usage in Pregnancy:
Furosemide tablets may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.
Furosemide tablets should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Furosemide tablets, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
There is a risk of ototoxic effects if cisplatin and Furosemide tablets are given concomitantly. In addition, nephrotoxicity of nephrotoxic drugs such as cisplatin may be enhanced if Furosemide tablets are not given in lower doses and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment.
Furosemide tablets have a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.
Lithium generally should not be given with diuretics because they reduce lithium’s renal clearance and add a high risk of lithium toxicity.
Furosemide tablets combined with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure. An interruption or reduction in the dosage of Furosemide tablets, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers may be necessary.
Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.
Furosemide tablets may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.
Simultaneous administration of sucralfate and Furosemide tablets may reduce the natriuretic and antihypertensive effects of Furosemide tablets. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Furosemide tablets is achieved. The intake of Furosemide tablets and sucralfate should be separated by at least two hours.
In isolated cases, intravenous administration of Furosemide tablets within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia. Use of Furosemide tablets concomitantly with chloral hydrate is, therefore, not recommended.
Phenytoin interferes directly with renal action of Furosemide tablets. There is evidence that treatment with phenytoin leads to decrease intestinal absorption of Furosemide tablets, and consequently to lower peak serum furosemide concentrations.
Methotrexate and other drugs that, like Furosemide tablets, undergo significant renal tubular secretion may reduce the effect of Furosemide tablets. Conversely, Furosemide tablets may decrease renal elimination of other drugs that undergo tubular secretion. High-dose treatment of both Furosemide tablets and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of Furosemide tablets.
Furosemide tablets can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment.
Concomitant use of cyclosporine and Furosemide tablets is associated with increased risk of gouty arthritis secondary to Furosemide tablets-induced hyperurecemia and cyclosporine impairment of renal urate excretion.
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Furosemide tablets (furesomide) in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and Furosemide tablets should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Furosemide tablets is achieved.
Lorzone should be used with caution in patients with known allergies or with a history of allergic reactions to drugs. If sensitivity reaction occurs such as urticaria, redness, or itching of the skin, the drug should be stopped.
If any symptoms suggestive of liver dysfunction are observed, the drug should be discontinued.
Chlorzoxazone-containing products are usually well tolerated. It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, light- headedness, malaise, or overstimulation may be noted by an occasional patient. Rarely, allergic-type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare. There is no evidence that the drug will cause renal damage. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. This finding is of no known clinical significance.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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