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Macrodantin

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Overview

What is Macrodantin?

Macrodantin

Macrodantin



What does Macrodantin look like?



What are the available doses of Macrodantin?

Sorry No records found.

What should I talk to my health care provider before I take Macrodantin?

Sorry No records found

How should I use Macrodantin?

Macrodantin

Escherichia coli,

, Staphylococcus aureus

Klebsiella

Enterobacter

Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of and other antibacterial drugs, should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections. Consequently, many patients who are treated with are predisposed to persistence or reappearance of bacteriuria. Urine specimens for culture and susceptibility testing should be obtained before and after completion of therapy. If persistence or reappearance of bacteriuria occurs after treatment with , other therapeutic agents with broader tissue distribution should be selected. In considering the use of , lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized.

Macrodantin


What interacts with Macrodantin?

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What are the warnings of Macrodantin?

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What are the precautions of Macrodantin?

Sorry No Records found


What are the side effects of Macrodantin?

Respiratory:

CHRONIC, SUBACUTE, OR ACUTE PULMONARY HYPERSENSITIVITY REACTIONS MAY OCCUR.

CHRONIC PULMONARY REACTIONS OCCUR GENERALLY IN PATIENTS WHO HAVE RECEIVED CONTINUOUS TREATMENT FOR SIX MONTHS OR LONGER. MALAISE, DYSPNEA ON EXERTION, COUGH, AND ALTERED PULMONARY FUNCTION ARE COMMON MANIFESTATIONS WHICH CAN OCCUR INSIDIOUSLY. RADIOLOGIC AND HISTOLOGIC FINDINGS OF DIFFUSE INTERSTITIAL PNEUMONITIS OR FIBROSIS, OR BOTH, ARE ALSO COMMON MANIFESTATIONS OF THE CHRONIC PULMONARY REACTION. FEVER IS RARELY PROMINENT.

THE SEVERITY OF CHRONIC PULMONARY REACTIONS AND THEIR DEGREE OF RESOLUTION APPEAR TO BE RELATED TO THE DURATION OF THERAPY AFTER THE FIRST CLINICAL SIGNS APPEAR. PULMONARY FUNCTION MAY BE IMPAIRED PERMANENTLY, EVEN AFTER CESSATION OF THERAPY. THE RISK IS GREATER WHEN CHRONIC PULMONARY REACTIONS ARE NOT RECOGNIZED EARLY.

In subacute pulmonary reactions, fever and eosinophilia occur less often than in the acute form. Upon cessation of therapy, recovery may require several months. If the symptoms are not recognized as being drug-related and nitrofurantoin therapy is not stopped, the symptoms may become more severe.

Acute pulmonary reactions are commonly manifested by fever, chills, cough, chest pain, dyspnea, pulmonary infiltration with consolidation or pleural effusion on x-ray, and eosinophilia. Acute reactions usually occur within the first week of treatment and are reversible with cessation of therapy. Resolution often is dramatic (see ).

Changes in EKG (e.g., non-specific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions.

Cyanosis has been reported rarely.

Hepatic:

Neurologic:

Asthenia, vertigo, nystagmus, dizziness, headache, and drowsiness also have been reported with the use of nitrofurantoin.

Benign intracranial hypertension (pseudotumor cerebri), confusion, depression, optic neuritis, and psychotic reactions have been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely.

Dermatologic:

Allergic:

Gastrointestinal:

Hematologic:

Miscellaneous:

Pseudomonas

Candida

Laboratory Adverse Events:


What should I look out for while using Macrodantin?

Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug.

Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38-42 weeks' gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age.

Macrodantin

Macrodantin


What might happen if I take too much Macrodantin?

Occasional incidents of acute overdosage of have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended. There is no specific antidote, but a high fluid intake should be maintained to promote urinary excretion of the drug. It is dialyzable.


How should I store and handle Macrodantin?

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .Macrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx OnlyMacrodantin25 mg opaque, white capsule imprinted with one black line encircling the capsule and coded "MACRODANTIN 25 mg" and "0149-0007."*NDC50 mg opaque, yellow and white capsule imprinted with two black lines encircling the capsule and coded "MACRODANTIN 50 mg" and "0149-0008."*NDCNDC100 mg opaque, yellow capsule imprinted with three black lines encircling the capsule and coded "MACRODANTIN 100 mg" and "0149-0009."*NDCNDC*Capsule design, registered trademark of Procter & Gamble Pharmaceuticals.Rx Only


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Microbiology:

Nitrofurantoin, in the form of , has been shown to be active against most strains of the following bacteria both and in clinical infections (see ):

NOTE: Some strains of species and species are resistant to nitrofurantoin.

Nitrofurantoin also demonstrates activity against the following microorganisms, although the clinical significance of these data with respect to treatment with is unknown:

Nitrofurantoin is not active against most strains of species or species. It has no activity against species.

Antagonism has been demonstrated between nitrofurantoin and quinolone antimicrobial agents. The clinical significance of this finding is unknown.

Non-Clinical Toxicology
Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug.

Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38-42 weeks' gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age.

Macrodantin

Macrodantin

Drug Interactions:

Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.

Information for Patients:

Macrodantin

Many patients who cannot tolerate microcrystalline nitrofurantoin are able to take without nausea.

Patients should be advised not to use antacid preparations containing magnesium trisilicate while taking .

Patients should be counseled that antibacterial drugs including should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by or other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).