MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only

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Overview

What is MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Chemically, Meclizine HCl is 1-( -chloro-α-phenylbenzyl)-4-( -methylbenzyl) piperazine dihydrochloride monohydrate.

C H ClN 2HCl H O M W 481 88 Meclizine HCI Tablets, USP are available in two different strengths: 12.5 mg and 25 mg. In addition each tablet contains the following inactive ingredients: Colloidal Silicon Dioxide, Croscarmellose Sodium, Lactose Monohydrate, Magnesium Stearate, Microcrystalline Cellulose. Also, Meclizine HCI Tablets USP, 12.5 mg contains FD&C Blue #1 Aluminum Lake (11-13%) and Meclizine HCI Tablets USP, 25 mg contains D&C Yellow #10 Aluminum Lake (15-20%).

What does MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only look like?

What are the available doses of MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

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What should I talk to my health care provider before I take MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Sorry No records found

How should I use MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

For the management of nausea and vomiting, and dizziness associated with motion sickness.

The initial dose of 25 to 50 mg of Meclizine HCI should be taken one hour prior to travel for protection against motion sickness. Thereafter, the dose may be repeated every 24 hours for the duration of the journey.

What interacts with MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Meclizine Hydrochloride is contraindicated in individuals who have shown a previous hypersensitivity to it.

What are the warnings of MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of , and surgical evaluation should be instituted as clinically indicated.

What are the precautions of MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Pregnancy Category B. Reproduction studies in rats have shown cleft palates at 25-50 times the human dose. Epidemiological studies in pregnant women, however, do not indicate that medicine increases the risk of abnormalities when administered during pregnancy. Despite the animal findings, it would appear that the possibility of fetal harm is remote. Nevertheless, meclizine, or any other medication, should be used during pregnancy only if clearly necessary. Clinical studies establishing safety and effectiveness in children have not been done; therefore, usage is not recommended in children under 12 years of age.

What are the side effects of MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

What should I look out for while using MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Meclizine Hydrochloride is contraindicated in individuals who have shown a previous hypersensitivity to it.

Since drowsiness may, on occasion, occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery. Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.

What might happen if I take too much MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Sorry No Records found

How should I store and handle MECLIZINE HYDROCHLORIDE TABLETS, USP Rx only?

Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature].Dispense in a tight container.Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature].Dispense in a tight container.NDC:50436-3986-1 in a BOTTLE of 30 TABLETS

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Meclizine Hydrochloride is an antihistamine which shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum.

Non-Clinical Toxicology

Meclizine Hydrochloride is contraindicated in individuals who have shown a previous hypersensitivity to it.

Since drowsiness may, on occasion, occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery. Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.

Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use of amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin. Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. This has been demonstrated ; however, the clinical significance of this interaction is not well documented.

In common with other antibiotics, amoxicillin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Pregnancy Category B. Reproduction studies in rats have shown cleft palates at 25-50 times the human dose. Epidemiological studies in pregnant women, however, do not indicate that medicine increases the risk of abnormalities when administered during pregnancy. Despite the animal findings, it would appear that the possibility of fetal harm is remote. Nevertheless, meclizine, or any other medication, should be used during pregnancy only if clearly necessary. Clinical studies establishing safety and effectiveness in children have not been done; therefore, usage is not recommended in children under 12 years of age.

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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