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estradiol
Overview
What is Menostar?
Menostar (estradiol transdermal system) is designed to provide nominal delivery of 14 mcg of estradiol per day continuously upon application to intact skin. The period of use is 7 days. The transdermal system has a contact surface area of 3.25 cm, and contains 1 mg of estradiol USP.
Estradiol USP is a white, crystalline powder, chemically described as estra-1,3,5(10)-triene-3, 17ß-diol. It has an empirical formula of CHO and molecular weight of 272.38. The structural formula is:
The Menostar transdermal system comprises three layers. Proceeding from the visible surface toward the surface attached to the skin, these layers are:
The active component of the transdermal system is estradiol. The remaining components of the transdermal system (acrylate copolymer adhesive, fatty acid esters, and polyethylene backing) are pharmacologically inactive.
What does Menostar look like?
What are the available doses of Menostar?
Menostar (estradiol transdermal system) 14 mcg per day - each 3.25 cm2 system contains 1 mg of estradiol.
What should I talk to my health care provider before I take Menostar?
How should I use Menostar?
Menostar is an estrogen indicated for:
Generally, when estrogen is prescribed for a postmenopausal woman with a uterus, a progestin should also be considered to reduce the risk of endometrial cancer. It is recommended that women who have a uterus and are treated with Menostar receive a progestin for 14 days every 6 to 12 months and undergo an endometrial biopsy at yearly intervals or as clinically indicated in order to detect any endometrial stimulation which might require further clinical action. A women without a uterus does not need a progestin. In some cases, however, hysterectomized women with a history of endometriosis may need a progestin .
Use of estrogen-alone, or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.
What interacts with Menostar?
Sorry No Records found
What are the warnings of Menostar?
Sorry No Records found
What are the precautions of Menostar?
Sorry No Records found
What are the side effects of Menostar?
Sorry No records found
What should I look out for while using Menostar?
Menostar is contraindicated in women with any of the following conditions:
What might happen if I take too much Menostar?
Overdosage of estrogen may cause nausea and vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding in women. Treatment of overdose consists of discontinuation of Menostar therapy with institution of appropriate symptomatic care.
How should I store and handle Menostar?
Prior to reconstitution, TYGACIL should be stored at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature.] The reconstituted solution of TYGACIL may be stored at room temperature (not to exceed 25°C/77°F) for up to 24 hours (up to 6 hours in the vial and the remaining time in the intravenous bag) .Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture). Captopril Tablets USP25 mg tablets Bottle of 30 - 68788-9731-3Bottle of 60 - 68788-9731-6Bottle of 90 - 68788-9731-9Bottle of 100 - 68788-9731-150 mg tablets Bottle of 30 - 68788-9721-3Bottle of 60 - 68788-9721-6Bottle of 90 - 68788-9721-9Bottle of 100 - 68788-9721-1Bottle contains desiccant.The 25 mg Captopril tablet is a white, flat bevelled-edge round with 902 a quadrisect bar on one side and ‘W’ on the other side and 903 on the other.The 50 mg Captopril tablet is a white, flat bevelled-edge round with a bisect bar on one side and ‘W’ on the other side and 904 on the other side.All captopril tablets are white and may exhibit a slight sulfurous odor.Dispense in a tight container as defined in the USP.StorageDo not store above 30°C (86°F) Keep bottles tightly closed (protect from moisture).
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.
The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, which is secreted by the adrenal cortex, to estrone in the peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women.
Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue.
Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.
Non-Clinical Toxicology
Menostar is contraindicated in women with any of the following conditions:Dual Blockade of the Renin-Angiotensin System (RAS)
Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on captopril and other agents that block the RAS.
Do not co-administer aliskiren with captopril in patients with diabetes. Avoid use of aliskiren with captopril in patients with renal impairment (GFR <60 ml/min).
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase - 2 Inhibitors (COX-2 Inhibitors)
In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including captopril, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving captopril and NSAID therapy. The antihypertensive effect of ACE inhibitors, including captopril, may be attenuated by NSAIDs.
Hypotension - Patients on Diuretic Therapy:
The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril tablets, USP or initiating therapy with small doses (6.25 or 12.5 mg). Alternatively, provide medical supervision for at least one hour after the initial dose. If hypotension occurs, the patient should be placed in a supine position and, if necessary, receive an intravenous infusion of normal saline. This transient hypotensive response is not a contraindication to further doses which can be given without difficulty once the blood pressure has increased after volume expansion.
Agents Having Vasodilator Activity:
Agents Causing Renin Release:
Agents Affecting Sympathetic Activity:
Agents Increasing Serum Potassium:
Lithium:
Cardiac Glycosides:
Loop Diuretics:
Allopurinol:
Gold:
An increased risk of stroke and DVT has been reported with estrogen-alone therapy. An increased risk of PE, DVT, stroke and MI has been reported with estrogen plus progestin therapy. Should any of these occur or be suspected, estrogen with or without progestin therapy should be discontinued immediately.
Risk factors for arterial vascular disease (for example, hypertension, diabetes mellitus, tobacco use, hypercholesterolemia, and obesity) and/or venous thromboembolism (VTE) (for example, personal history or family history of VTE, obesity, and systemic lupus erythematosus) should be managed appropriately.
The following serious adverse reactions are discussed elsewhere in the labeling:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
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