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Meropenem
Overview
What is Meropenem?
Meropenem for Injection, USP is a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibacterial for intravenous administration. It is (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate. Its molecular formula is CHNOS•3HO with a molecular weight of 437.52. Its structural formula is:
Meropenem for Injection, USP is a white to pale yellow crystalline powder. The solution varies from colorless to yellow depending on the concentration. The pH of freshly constituted solutions is between 7.3 and 8.3. Meropenem, USP is a colorless to white or light yellow crystals or crystalline powder and is soluble in 5% monobasic potassium phosphate solution, sparingly soluble in water, very slightly soluble in hydrated ethanol, and practically insoluble in acetone or ether.
When re-constituted as instructed, each 1 gram Meropenem for Injection, USP vial will deliver 1 gram of meropenem, USP and 90.2 mg of sodium as sodium carbonate (3.92 mEq). Each 500 mg Meropenem for Injection, USP vial will deliver 500 mg meropenem, USP and 45.1 mg of sodium as sodium carbonate (1.96 mEq) [
].
What does Meropenem look like?



What are the available doses of Meropenem?
500 mg Meropenem for Injection Vial ()
1 gram Meropenem for Injection Vial ()
What should I talk to my health care provider before I take Meropenem?
How should I use Meropenem?
Meropenem for Injection is indicated for the treatment of complicated skin and skin structure infections (cSSSI) due to (methicillin-susceptible isolates only),
viridans group streptococci, (vancomycin-susceptible isolates only), and species.
The recommended dose of Meropenem for Injection is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. When treating complicated skin and skin structure infections caused by , a dose of 1 gram every 8 hours is recommended.
Meropenem for Injection should be administered by intravenous infusion over approximately 15 minutes to 30 minutes. Doses of 1 gram may also be administered as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes.
What interacts with Meropenem?
Sorry No Records found
What are the warnings of Meropenem?
Sorry No Records found
What are the precautions of Meropenem?
Sorry No Records found
What are the side effects of Meropenem?
Sorry No records found
What should I look out for while using Meropenem?
Meropenem for Injection is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta (β)-lactams.
What might happen if I take too much Meropenem?
In mice and rats, large intravenous doses of meropenem (2,200 mg/kg to 4,000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.
Intentional overdosing of Meropenem for Injection is unlikely, although accidental overdosing might occur if large doses are given to patients with reduced renal function. The largest dose of meropenem administered in clinical trials has been 2 grams given intravenously every 8 hours. At this dosage, no adverse pharmacological effects or increased safety risks have been observed.
Limited postmarketing experience indicates that if adverse events occur following overdosage, they are consistent with the adverse event profile described in the Adverse Reactions section and are generally mild in severity and resolve on withdrawal or dose reduction. Consider symptomatic treatments. In individuals with normal renal function, rapid renal elimination takes place. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis; however, no information is available on the use of hemodialysis to treat overdosage.
How should I store and handle Meropenem?
Store at 20°C to 25°C (68°F to 77°F) [See USP controlled room temperature]. Protect from moisture.Meropenem for Injection, USP is a sterile, pyrogen-free, white to pale yellow crystalline powder and is supplied in vials containing sufficient meropenem to deliver 500 mg or 1 g for intravenous administration, respectively. Meropenem for Injection, USP is available as follows: 10 Vials in a carton NDC 55150-207-20 10 Vials in a carton NDC 55150-208-30The dry powder should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. The vial stoppers are not made with natural rubber latex.Meropenem for Injection, USP is a sterile, pyrogen-free, white to pale yellow crystalline powder and is supplied in vials containing sufficient meropenem to deliver 500 mg or 1 g for intravenous administration, respectively. Meropenem for Injection, USP is available as follows: 10 Vials in a carton NDC 55150-207-20 10 Vials in a carton NDC 55150-208-30The dry powder should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. The vial stoppers are not made with natural rubber latex.Meropenem for Injection, USP is a sterile, pyrogen-free, white to pale yellow crystalline powder and is supplied in vials containing sufficient meropenem to deliver 500 mg or 1 g for intravenous administration, respectively. Meropenem for Injection, USP is available as follows: 10 Vials in a carton NDC 55150-207-20 10 Vials in a carton NDC 55150-208-30The dry powder should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. The vial stoppers are not made with natural rubber latex.