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metronidazole

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Overview

What is MetroCream?

METROCREAM Topical Cream contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in an emollient cream consisting of benzyl alcohol, emulsifying wax, glycerin, isopropyl palmitate, purified water, sorbitol solution, lactic acid and/or sodium hydroxide to adjust pH. Metronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and anti-bacterial agent. Chemically, metronidazole is 2-methyl-5-nitro-1 imidazole-1-ethanol. The molecular formula is CHNO and molecular weight is 171.16. Metronidazole is represented by the following structural formula:



What does MetroCream look like?



What are the available doses of MetroCream?

Sorry No records found.

What should I talk to my health care provider before I take MetroCream?

Sorry No records found

How should I use MetroCream?

METROCREAM (metronidazole topical cream) Topical Cream is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.

Apply and rub in a thin layer of METROCREAM (metronidazole topical cream) Topical Cream twice daily, morning and evening, to entire affected areas after washing.

Areas to be treated should be washed with a mild cleanser before application. Patients may use cosmetics after application of METROCREAMTopical Cream.


What interacts with MetroCream?

Sorry No Records found


What are the warnings of MetroCream?

Sorry No Records found


What are the precautions of MetroCream?

Sorry No Records found


What are the side effects of MetroCream?

In controlled clinical trials, the total incidence of adverse reactions associated with the use of METROCREAM Topical Cream was approximately 10%. Skin discomfort (burning and stinging) was the most frequently reported event followed by erythema, skin irritation, pruritus and worsening of rosacea. All individual events occurred in less than 3% of patients. The following additional adverse experiences have been reported with the topical use of metronidazole: dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.


What should I look out for while using MetroCream?

METROCREAM (metronidazole topical cream) Topical Cream is contraindicated in individuals with a history of hypersensitivity to metronidazole, or other ingredients of the formulation.


What might happen if I take too much MetroCream?

Sorry No Records found


How should I store and handle MetroCream?

Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F).METROCREAM (metronidazole topical cream) Topical Cream, 0.75% is supplied in a 45 g aluminum tube - 0299-3836-45.Storage conditions:Marketed by: GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177 USAManufactured by:Galderma Production Canada, Inc.Montreal, QCH9X 3N7 CanadaGALDERMA is a registered trademark.Made in Canada.P50309-0Revised: December 2002METROCREAM (metronidazole topical cream) Topical Cream, 0.75% is supplied in a 45 g aluminum tube - 0299-3836-45.Storage conditions:Marketed by: GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177 USAManufactured by:Galderma Production Canada, Inc.Montreal, QCH9X 3N7 CanadaGALDERMA is a registered trademark.Made in Canada.P50309-0Revised: December 2002METROCREAM (metronidazole topical cream) Topical Cream, 0.75% is supplied in a 45 g aluminum tube - 0299-3836-45.Storage conditions:Marketed by: GALDERMA LABORATORIES, L.P.Fort Worth, Texas 76177 USAManufactured by:Galderma Production Canada, Inc.Montreal, QCH9X 3N7 CanadaGALDERMA is a registered trademark.Made in Canada.P50309-0Revised: December 2002


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The mechanisms by which metronidazole acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.

Non-Clinical Toxicology
METROCREAM (metronidazole topical cream) Topical Cream is contraindicated in individuals with a history of hypersensitivity to metronidazole, or other ingredients of the formulation.

General:

Information for patients:

Drug interactions:

Carcinogenesis, mutagenesis, impairment of fertility:

Metronidazole has shown evidence of mutagenic activity in several bacterial assay systems. In addition, a dose-response increase in the frequency of micronuclei was observed in mice after intraperitoneal injections and an increase in chromosome aberrations have been reported in patients with Crohn’s disease who were treated with 200-1200 mg/day of metronidazole for 1 to 24 months. However, no excess chromosomal aberrations in circulating human lymphocytes have been observed in patients treated for 8 months.

Pregnancy:

Teratogenic effects: Pregnancy category B:

Nursing mothers:

Pediatric use: Safety and effectiveness in pediatric patients have not been established.

In controlled clinical trials, the total incidence of adverse reactions associated with the use of METROCREAM Topical Cream was approximately 10%. Skin discomfort (burning and stinging) was the most frequently reported event followed by erythema, skin irritation, pruritus and worsening of rosacea. All individual events occurred in less than 3% of patients. The following additional adverse experiences have been reported with the topical use of metronidazole: dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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