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METROGEL
Overview
What is METROGEL?
METROGEL (metronidazole) Gel, 1% contains metronidazole, USP. Chemically, metronidazole is 2-methyl-5-nitro-1 -imidazole-1-ethanol. The molecular formula for metronidazole is CHNO. It has the following structural formula:
Metronidazole has a molecular weight of 171.16. It is a white to pale yellow crystalline powder. It is slightly soluble in alcohol and has solubility in water of 10 mg/mL at 20˚C. Metronidazole belongs to the nitroimidazole class of compounds.
METROGEL is a clear, colorless to pale yellow, aqueous gel; each gram contains 10 mg of metronidazole in a base of betadex, edetate disodium, hydroxyethyl cellulose, methylparaben, niacinamide, phenoxyethanol, propylene glycol, propylparaben and purified water.
What does METROGEL look like?
What are the available doses of METROGEL?
Gel, 1%.
What should I talk to my health care provider before I take METROGEL?
How should I use METROGEL?
Apply and rub in a thin film of METROGEL once daily to affected area(s).
A gentle cleanser should be used before the application of METROGEL.
Cosmetics may be applied after the application of METROGEL.
Not for oral, ophthalmic or intravaginal use.
What interacts with METROGEL?
Sorry No Records found
What are the warnings of METROGEL?
Sorry No Records found
What are the precautions of METROGEL?
Sorry No Records found
What are the side effects of METROGEL?
Sorry No records found
What should I look out for while using METROGEL?
METROGEL is contraindicated in patients with a history of hypersensitivity to metronidazole or to any other ingredient in the formulation.
What might happen if I take too much METROGEL?
There are no reported human experiences with overdosage of METROGEL. Topically applied metronidazole can be absorbed in sufficient amount to produce systemic effects.
How should I store and handle METROGEL?
Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). Avoid freezing and protect from light.METROGEL a clear, colorless to pale yellow in color, and is supplied as follows: 60 gram tube - 0299-3820-6055 gram pump - 0299-3820-01 Storage Conditions:METROGEL a clear, colorless to pale yellow in color, and is supplied as follows: 60 gram tube - 0299-3820-6055 gram pump - 0299-3820-01 Storage Conditions:METROGEL a clear, colorless to pale yellow in color, and is supplied as follows: 60 gram tube - 0299-3820-6055 gram pump - 0299-3820-01 Storage Conditions:
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The mechanism of action of metronidazole in the treatment of rosacea is unknown.
Non-Clinical Toxicology
METROGEL is contraindicated in patients with a history of hypersensitivity to metronidazole or to any other ingredient in the formulation.When probenecid is used to elevate plasma concentrations of penicillin or other betalactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. In the case of penicillin or other beta-lactams, psychic disturbances have been reported.
The use of salicylates antagonizes the uricosuric action of probenecid (see ). The uricosuric action of probenecid is also antagonized by pyrazinamide.
Probenecid produces an insignificant increase in free sulfonamide plasma concentrations but a significant increase in total sulfonamide plasma levels. Since probenecid decreases the renal excretion of conjugated sulfonamides, plasma concentrations of the latter should be determined from time to time when a sulfonamide and probenecid are coadministered for prolonged periods. Probenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia.
It has been reported that patients receiving probenecid require significantly less thiopental for induction of anesthesia. In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid.
The concomitant administration of probenecid increases the mean plasma elimination half-life of a number of drugs which can lead to increased plasma concentrations. These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. Although the clinical significance of this observation has not been established, a lower dosage of the drug may be required to produce a therapeutic effect, and increases in dosage of the drug in question should be made cautiously and in small increments when probenecid is being co-administered. Although specific instances of toxicity due to this potential interaction have not been observed to date, physicians should be alert to this possibility.
Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. Sulindac was shown to produce a modest reduction in the uricosuric action of probenecid, which probably is not significant under most circumstances.
In animals and in humans, probenecid has been reported to increase plasma concentrations of methotrexate (see ).
Falsely high readings for theophylline have been reported in an study, using the Schack and Waxler technic, when therapeutic concentrations of theophylline and probenecid were added to human plasma.
Peripheral neuropathy, characterized by numbness or paresthesia of an extremity has been reported in patients treated with systemic metronidazole. Although not evident in clinical trials for topical metronidazole, peripheral neuropathy has been reported with the post approval use. The appearance of abnormal neurologic signs should prompt immediate reevaluation of METROGEL therapy. Metronidazole should be administered with caution to patients with central nervous system diseases.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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