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mitomycin

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Overview

What is Mitosol?

Mitomycin is an antibiotic isolated from the broth of which has been shown to have antimetabolic activity.

Mitomycin is a blue-violet crystalline powder with the molecular formula of CHNO and a molecular weight of 334.33. Its chemical name is 7-amino-9α-methoxymitosane and it has the following structural formula:

Mitosol is a sterile lyophiliized mixture of mitomycin and mannitol, which, when reconstituted with Sterile Water for Injection, provides a solution for application in glaucoma filtration surgery. Mitosol is supplied in vials containing 0.2 mg of mitomycin. Each vial also contains mannitol 0.4 mg, at a 1:2 ratio of mitomycin to mannitol. Each mL of reconstituted solution contains 0.2 mg mitomycin and has a pH between 5.0 and 8.0.



What does Mitosol look like?



What are the available doses of Mitosol?

Each vial contains a sterile lyophilized mixture of 0.2 mg mitomycin and 0.4 mg mannitol; when reconstituted with Sterile Water for Injection, the solution contains 0.2 mg/mL mitomycin. ()

What should I talk to my health care provider before I take Mitosol?

How should I use Mitosol?

Mitosol is an antimetabolite indicated for use as an adjunct to ab externo glaucoma surgery.

Mitosol is intended for topical application to the surgical site of glaucoma filtration surgery. It is not intended for intraocular administration. If intraocular administration occurs, cell death leading to corneal infarction, retinal infarction, and ciliary body atrophy may result.


What interacts with Mitosol?

Sorry No Records found


What are the warnings of Mitosol?

Sorry No Records found


What are the precautions of Mitosol?

Sorry No Records found


What are the side effects of Mitosol?

Sorry No records found


What should I look out for while using Mitosol?

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4.1

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4.2


What might happen if I take too much Mitosol?

Sorry No Records found


How should I store and handle Mitosol?

Benzonatate capsules USP, 100 mg are light yellow-colored, round-shaped soft gelatin capsules, imprinted with "Z" containing pale yellow-colored clear viscous liquid and are supplied as follows:NDC 0904-6564-60 in bottle of 100 capsulesStore at 20° - 25°C (68° - 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Benzonatate capsules USP, 100 mg are light yellow-colored, round-shaped soft gelatin capsules, imprinted with "Z" containing pale yellow-colored clear viscous liquid and are supplied as follows:NDC 0904-6564-60 in bottle of 100 capsulesStore at 20° - 25°C (68° - 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Benzonatate capsules USP, 100 mg are light yellow-colored, round-shaped soft gelatin capsules, imprinted with "Z" containing pale yellow-colored clear viscous liquid and are supplied as follows:NDC 0904-6564-60 in bottle of 100 capsulesStore at 20° - 25°C (68° - 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Benzonatate capsules USP, 100 mg are light yellow-colored, round-shaped soft gelatin capsules, imprinted with "Z" containing pale yellow-colored clear viscous liquid and are supplied as follows:NDC 0904-6564-60 in bottle of 100 capsulesStore at 20° - 25°C (68° - 77°F) [See USP Controlled Room Temperature].Dispense in a tight, light-resistant container.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Mitosol inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. Cellular RNA and protein synthesis may also be suppressed.

Non-Clinical Toxicology
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4.1

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4.2

Mitomycin is cytotoxic. Use of mitomycin in concentrations higher than 0.2 mg/mL or use for longer than 2 minutes may lead to unintended corneal and/or scleral damage including thinning or perforation. Direct contact with the corneal endothelium will result in cell death.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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