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Morphine Sulfate

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Overview

What is Morphine Sulfate Oral Solution CII?

Chemically, morphine sulfate is 7,8-didehydro-4,5 alpha-epoxy-17 methyl-morphinan-3,6 alpha-diol sulfate (2:1) (salt) pentahydrate with a molecular mass of 758. Morphine sulfate occurs as a white to off-white crystalline solid. It is soluble in water and slightly soluble in alcohol, but is practically insoluble in chloroform or ether. The octanol:water partition coefficient of morphine is 1.42 at physiologic pH and the pKa is 7.9 for the tertiary nitrogen (the majority is ionized at pH 7.4).

For the 10 mg and 20 mg per 5 mL strengths: Each 5 mL of oral solution contains 10 or 20 mg of morphine sulfate, USP and the following inactive ingredients: anhydrous citric acid, edetate disodium, FD&C Green No. 3 (fast green), glycerin, sodium benzoate, sorbitol and water and if necessary sodium citrate to adjust pH.

For the 100 mg per 5 mL (20 mg/mL) strength: Each 5 mL of oral solution contains 100 mg of morphine sulfate, USP and the following inactive ingredients: anhydrous citric acid, edetate disodium, glycerin, sodium benzoate, sorbitol and water and if necessary sodium citrate to adjust pH.



What does Morphine Sulfate Oral Solution CII look like?



What are the available doses of Morphine Sulfate Oral Solution CII?

Oral Solution: For the 10 mg per 5 mL or 20 mg per 5 mL strengths, each mL contains 2 mg or 4 mg of morphine sulfate. For the 100 mg per 5 mL (20 mg/mL) strength, each mL contains 20 mg of morphine sulfate. ()

What should I talk to my health care provider before I take Morphine Sulfate Oral Solution CII?

How should I use Morphine Sulfate Oral Solution CII?

Morphine sulfate solution are formulations of morphine, an opioid agonist, indicated for the relief of moderate to severe acute and chronic pain where use of an opioid analgesic is appropriate. Morphine sulfate solution (20 mg/mL) is an opioid analgesic indicated for the relief of moderate to severe acute and chronic pain in opioid-tolerant patients.

Morphine sulfate oral solution 100 mg per 5 mL (20 mg/mL) may cause fatal respiratory depression when administered to patients not previously exposed to opioids. Patients considered to be opioid tolerant are those who are taking at least 60 mg oral morphine per day, or at least 30 mg of oral oxycodone per day, or at least 12 mg hydromorphone per day, or an equianalgesic dose of another opioid, for a week or longer.

Morphine Sulfate Oral Solution is available in three concentrations: 10 mg per 5 mL, 20 mg per 5 mL and 100 mg per 5 mL (20 mg/mL).

Take care when prescribing and administering Morphine Sulfate Oral Solution to avoid dosing errors due to confusion between different concentrations and between mg and mL, which could result in accidental overdose and death. Take care to ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume. Always use the enclosed calibrated oral syringe when administering Morphine Sulfate Oral Solution 100 mg per 5 mL (20 mg/mL) to ensure the dose is measured and administered accurately.

Selection of patients for treatment with morphine sulfate should be governed by the same principles that apply to the use of similar opioid analgesics. Individualize treatment in every case, using non-opioid analgesics, opioids on an as needed basis and/or combination products, and chronic opioid therapy in a progressive plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research and Quality, and the American Pain Society.


What interacts with Morphine Sulfate Oral Solution CII?

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What are the warnings of Morphine Sulfate Oral Solution CII?

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What are the precautions of Morphine Sulfate Oral Solution CII?

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What are the side effects of Morphine Sulfate Oral Solution CII?

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What should I look out for while using Morphine Sulfate Oral Solution CII?

Morphine sulfate is contraindicated in patients with known hypersensitivity to morphine, morphine salts, or any components of the product.

Morphine sulfate is contraindicated in patients with respiratory depression in the absence of resuscitative equipment.

Morphine sulfate is contraindicated in patients with acute or severe bronchial asthma or hypercarbia.

Morphine sulfate is contraindicated in any patient who has or is suspected of having paralytic ileus.


What might happen if I take too much Morphine Sulfate Oral Solution CII?


How should I store and handle Morphine Sulfate Oral Solution CII?

Store refrigerated between 2° and 8°C (36° and 46°F). Protect from light.Store refrigerated between 2° and 8°C (36° and 46°F). Protect from light.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.Morphine Sulfate Oral Solution10 mg per 5 mL Oral Solution20 mg per 5 mL Oral SolutionMorphine Sulfate Oral Solution 100 mg per 5 mL is a clear/colorless solution available in one strengths as follows: NDC 70408-746-29 Bottle of 30 mL with an oral syringeNDC 70408-746-31 Bottle of 120 mL with an oral syringeStoragePROTECT FROM MOISTURE.All opioids are liable to diversion and misuse both by the general public and healthcare workers and should be handled accordingly.