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mupirocin

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Overview

What is Mupirocin?

Each gram of mupirocin ointment USP, 2% contains 20 mg mupirocin in a bland water miscible ointment base (polyethylene glycol ointment, N.F.) consisting of polyethylene glycol 400 and polyethylene glycol 3350.

Mupirocin is a naturally occurring antibiotic. The chemical name is ()-(2,3,4,5)-5-[(2,3,4,5)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-β-methyl-2-pyran-2-crotonic acid,ester with 9-hydroxynonanoic acid.

The molecular formula of mupirocin is CHO and the molecular weight is 500.63. The chemical structure is:



What does Mupirocin look like?



What are the available doses of Mupirocin?

Sorry No records found.

What should I talk to my health care provider before I take Mupirocin?

Sorry No records found

How should I use Mupirocin?

Mupirocin ointment, 2% is indicated for the topical treatment of impetigo due to: and .

A small amount of mupirocin ointment should be applied to the affected area three times daily. The area treated may be covered with a gauze dressing if desired. Patients not showing a clinical response within 3 to 5 days should be re-evaluated.


What interacts with Mupirocin?

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.



What are the warnings of Mupirocin?

Use of Chloroquine Phosphate Tablets in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. The drug should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the potential risks.


What are the precautions of Mupirocin?

If a reaction suggesting sensitivity or chemical irritation should occur with the use of mupirocin ointment 2%, treatment should be discontinued and appropriate alternative therapy for the infection instituted. As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. Mupirocin ointment is not formulated for use on mucosal surfaces. Intranasal use has been associated with isolated reports of stinging and drying.

Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. In common with other polyethylene glycol-based ointments, mupirocin ointment should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment. A paraffin-based formulation- *Bactroban Nasal (mupirocin calcium ointment) - is available for intranasal use.

Information for Patients:

Drug Interactions:

Carcinogenesis, Mutagenesis, Impairment of Fertility:

in vitro

in vivo

Salmonella

Escherichia coli

Pregnancy Teratogenic Effects.Pregnancy Category B:

Nursing Mothers:

mupirocin ointment

Pediatric Use:

mupirocin ointment

mupirocin ointment

mupirocin ointment


What are the side effects of Mupirocin?

The following local adverse reactions have been reported in connection with the use of : burning, stinging, or pain in 1.5% of patients; itching in 1% of patients; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of patients.


What should I look out for while using Mupirocin?

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.

Mupirocin ointment is not for ophthalmic use.


What might happen if I take too much Mupirocin?

Sorry No Records found


How should I store and handle Mupirocin?

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature].Mupirocin Ointment USP, 2% is supplied                   22 gram tubeStore at 20° to 25°C (68° to 77°F)[see USP Controlled Room Temperature].*Bactroban Nasal is a registered trademark of SmithKline Pharmaceuticals.E. FOUGERA & CO.I2352BR9/07Mupirocin Ointment USP, 2% is supplied                   22 gram tubeStore at 20° to 25°C (68° to 77°F)[see USP Controlled Room Temperature].*Bactroban Nasal is a registered trademark of SmithKline Pharmaceuticals.E. FOUGERA & CO.I2352BR9/07Mupirocin Ointment USP, 2% is supplied                   22 gram tubeStore at 20° to 25°C (68° to 77°F)[see USP Controlled Room Temperature].*Bactroban Nasal is a registered trademark of SmithKline Pharmaceuticals.E. FOUGERA & CO.I2352BR9/07Mupirocin Ointment USP, 2% is supplied                   22 gram tubeStore at 20° to 25°C (68° to 77°F)[see USP Controlled Room Temperature].*Bactroban Nasal is a registered trademark of SmithKline Pharmaceuticals.E. FOUGERA & CO.I2352BR9/07Mupirocin Ointment USP, 2% is supplied                   22 gram tubeStore at 20° to 25°C (68° to 77°F)[see USP Controlled Room Temperature].*Bactroban Nasal is a registered trademark of SmithKline Pharmaceuticals.E. FOUGERA & CO.I2352BR9/07


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Application of C-labeled mupirocin ointment to the lower arm of normal male subjects followed by occlusion for 24 hours showed no measurable systemic absorption (<1.1 nanogram mupirocin per milliliter of whole blood). Measurable radioactivity was present in the stratum corneum of these subjects 72 hours after application.

Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite, monic acid, is eliminated by renal excretion, and demonstrates no antibacterial activity. In a study conducted in seven healthy adult male subjects, the elimination half-life after intravenous administration of mupirocin was 20 to 40 minutes for mupirocin and 30 to 80 minutes for monic acid. The pharmacokinetics of mupirocin has not been studied in individuals with renal insufficiency.

Non-Clinical Toxicology
This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.

Mupirocin ointment is not for ophthalmic use.

Drug Interactions:

If a reaction suggesting sensitivity or chemical irritation should occur with the use of mupirocin ointment 2%, treatment should be discontinued and appropriate alternative therapy for the infection instituted. As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. Mupirocin ointment is not formulated for use on mucosal surfaces. Intranasal use has been associated with isolated reports of stinging and drying.

Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. In common with other polyethylene glycol-based ointments, mupirocin ointment should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment. A paraffin-based formulation- *Bactroban Nasal (mupirocin calcium ointment) - is available for intranasal use.

The following local adverse reactions have been reported in connection with the use of : burning, stinging, or pain in 1.5% of patients; itching in 1% of patients; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of patients.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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