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Naltrexone

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Overview

What is Naltrexone?

Naltrexone Implant Formula:17-(Cyclopropilmethil)-4,5ª-Epoxy-3,14-dihidroximorfinan-6-ona

Formula molecular CHNOCHNO

Naltrexone Implants are supplied in a kit containing 6 X 200mg pellets, to be administered via a 4.5mm diameter trocar subcutaneously.

Additionally, each implant contains 3% triamcinolone as an active ingredient, as well as ascorbic acid, stearic acid, and polyvinylpyrrolidone as inactive ingredients.

Naltrexone implants are white, biconvex, with an elongated shape. Each Naltrexone 200mg implant is 0.215gm, with a diameter of 4.5mm and a length of 11mm.



What does Naltrexone look like?



What are the available doses of Naltrexone?

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What should I talk to my health care provider before I take Naltrexone?

Sorry No records found

How should I use Naltrexone?

Treatment with naltrexone implants should be part of a comprehensive management program that includes psychological and psychosocial support.

Naltrexone tablets were initially approved by the FDA in 1985 for the treatment of abuse and addiction of opioids.

Naltrexone in oral and extended release injection forms have been approved by the FDA for the treatment and abuse of alcohol.

Naltrexone implants may be useful for the treatment of alcohol or opioid dependence in patients who are able to abstain from opioid or alcohol in an outpatient setting prior to initiation of treatment.

Patients should not be actively drinking or be on any opioids at the time of initial naltrexone implant administration.

Naltrexone implants must be administered by a physician.

To prevent occurrence of an acute abstinence syndrome (withdrawal) in patients dependent on opioids, or exacerbation of a pre-existing subclinical abstinence syndrome, opioid-dependent patients, including those being treated for alcohol dependence, must be opioid-free for a minimum of 7–10 days before starting Naltrexone Implant treatment. Since the absence of an opioid drug in the urine is often not sufficient proof that a patient is opioid-free, a naloxone challenge test should be employed if the prescribing physician feels there is a risk of precipitating a withdrawal reaction following administration of Naltrexone Implants. Patients treated for alcohol dependence with Naltrexone Implants should be assessed for underlying opioid dependence and for any recent use of opioids prior to initiation of treatment with Naltrexone Implants. Precipitated opioid withdrawal has been observed in alcohol-dependent patients in circumstances where the prescriber had been unaware of the additional use of opioids or dependence on opioids.

The aluminum (back) part of the blister packs should be wiped with sterile 70% isopropyl alcohol pads prior to opening. Implants should be handled via aseptic technique and should be used immediately.

The recommended dose of Naltrexone implants is 1200mg delivered subcutaneously every 10-12 weeks.

Reemergence of cravings should be screened and may be used as a gauge for the need for re-implantation schedule.

Healthcare providers should tailor the length of treatment to individual patients. Naltrexone has been administered to patients who are alcohol dependent for 6 months to 1 year with no additional safety concerns. Many scientists claim that treatment duration should last at least 1 year since this is the amount of time it can take to change the brain’s addiction pathways.

Treatment with Naltrexone should be part of a psychological and psychosocial program.


What interacts with Naltrexone?

Sorry No Records found


What are the warnings of Naltrexone?

Sorry No Records found


What are the precautions of Naltrexone?

Sorry No Records found


What are the side effects of Naltrexone?

Sorry No records found


What should I look out for while using Naltrexone?

Naltrexone is contraindicated in:

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What might happen if I take too much Naltrexone?

Sorry No Records found


How should I store and handle Naltrexone?

Unopened vials of gemcitabine for injection, USP are stable until the expiration date indicated on the package when stored at controlled room temperature 20° to 25°C (68° to 77°F) and that allows for excursions between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature] [].Naltrexone implants are available in a box of 6 X 200mg Naltrexone implants. Each implant is individually blister packed.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
Naltrexone is contraindicated in:











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Citalopram tablets 20 mg/day is the maximum recommended dose for patients taking concomitant cimetidine because of the risk of QT prolongation (see ).

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Naltrexone has the capacity to cause hepatocellular injury when given in excessive doses. Naltrexone is contraindicated in acute hepatitis or liver failure, and its use in patients with active liver disease must be carefully considered in light of its hepatotoxic effects.

The margin of separation between the apparently safe dose of naltrexone and the dose causing hepatic injury appears to be only five-fold or less. Naltrexone implants do not appear to be a hepatotoxin at the recommended doses.

Patients should be warned of the risk of hepatic injury and advised to seek medical attention if they experience symptoms of acute hepatitis. Use of Naltrexone implants should be discontinued in the event of symptoms and/or signs of acute hepatitis.

Naltrexone may cause side effects including:

The other common side effects of Naltrexone are:

These are not all of the side effects of naltrexone.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).