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NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC
Overview
What is NEO-POLYCIN?
Neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, bacitracin zinc equivalent to 400 bacitracin units in a white petrolatum and mineral oil base.
Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of Waksman (Fam. ). It has a potency equivalent of not less than 600 µg of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are:
Polymyxin B sulfate is the sulfate salt of polymyxin B and B, which are produced by the growth of (Prazmowski) Migula (Fam. ). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:
Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the
licheniformis
group of
Bacillus subtilis
var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is:
What does NEO-POLYCIN look like?
What are the available doses of NEO-POLYCIN?
Sorry No records found.
What should I talk to my health care provider before I take NEO-POLYCIN?
Sorry No records found
How should I use NEO-POLYCIN?
Neo-Polycin Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis, and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
May be applied every 3 or 4 hours for 7 to 10 days, depending on the severity of the infection.
What interacts with NEO-POLYCIN?
Sorry No Records found
What are the warnings of NEO-POLYCIN?
Sorry No Records found
What are the precautions of NEO-POLYCIN?
Sorry No Records found
What are the side effects of NEO-POLYCIN?
Adverse reactions have occurred with the anti-infective components of neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment. The exact incidence is not known. Reactions occurring most often are allergic sensitization reactions including itching, swelling, and conjunctival erythema (see ). More serious hypersensitivity reactions, including anaphylaxis, have been reported rarely. Local irritation on instillation has also been reported.
To report SUSPECTED ADVERSE REACTIONS, contact Fera Pharmaceuticals, LLC at (414) 434-6604, Monday-Friday 9am-5pm EST or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What should I look out for while using NEO-POLYCIN?
Neo-Polycin Ophthalmic Ointment is contraindicated in individuals who have shown hypersensitivity to any of its components.
NOT FOR INJECTION INTO THE EYE. Neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment should never be directly introduced into the anterior chamber of the eye. Ophthalmic ointments may retard corneal wound healing. Topical antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization. A precise incidence of hypersensitivity reactions (primarily skin rash) due to topical antibiotics is not known. The manifestations of sensitization to topical antibiotics are usually itching, reddening, and edema of the conjunctiva and eyelid. A sensitization reaction may manifest simply as a failure to heal. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Symptoms usually subside quickly on withdrawing the medication. Applications of products containing these ingredients should be avoided for the patient thereafter (see ).
What might happen if I take too much NEO-POLYCIN?
Sorry No Records found
How should I store and handle NEO-POLYCIN?
SUSTIVA capsules and SUSTIVA tablets should be stored at 25° C (77° F); excursions permitted to 15°–30° C (59°–86° F) [see USP Controlled Room Temperature].Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320Neo-Polycin Ophthalmic Ointment is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip.Store at 20-25C (68-77F) [See USP Controlled room temperature]. Neo-Polycin is a Trademark of Fera Pharmaceuticals, LLC. FERAMfd. for:Fera Pharmaceuticals, LLCLocust Valley, NY 11560Repackaged by: Rebel Distributors Corp.Thousand Oaks, CA 91320
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
A wide range of antibacterial action is provided by the overlapping spectra of neomycin, polymyxin B sulfate, and bacitracin.
Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code.
Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.
Bacitracin is bactericidal for a variety of gram-positive and gram-negative organisms. It interferes with bacterial cell wall synthesis by inhibition of the regeneration of phospholipid receptors involved in peptidoglycan synthesis.
Non-Clinical Toxicology
Neo-Polycin Ophthalmic Ointment is contraindicated in individuals who have shown hypersensitivity to any of its components.NOT FOR INJECTION INTO THE EYE. Neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment should never be directly introduced into the anterior chamber of the eye. Ophthalmic ointments may retard corneal wound healing. Topical antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization. A precise incidence of hypersensitivity reactions (primarily skin rash) due to topical antibiotics is not known. The manifestations of sensitization to topical antibiotics are usually itching, reddening, and edema of the conjunctiva and eyelid. A sensitization reaction may manifest simply as a failure to heal. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Symptoms usually subside quickly on withdrawing the medication. Applications of products containing these ingredients should be avoided for the patient thereafter (see ).
Due to potential for additive effects, caution is warranted in patients receiving diltiazem hydrochloride injection concomitantly with other agent(s) known to affect cardiac contractility and/or SA or AV node conduction (see ).
As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem hydrochloride undergoes extensive metabolism by the cytochrome P-450 mixed function oxidase system. Although specific pharmacokinetic drug-drug interaction studies have not been conducted with single intravenous injection or constant rate intravenous infusion, coadministration of diltiazem hydrochloride injection with other agents which primarily undergo the same route of biotransformation may result in competitive inhibition of metabolism.
Adverse reactions have occurred with the anti-infective components of neomycin and polymyxin B sulfates and bacitracin zinc ophthalmic ointment. The exact incidence is not known. Reactions occurring most often are allergic sensitization reactions including itching, swelling, and conjunctival erythema (see ). More serious hypersensitivity reactions, including anaphylaxis, have been reported rarely. Local irritation on instillation has also been reported.
To report SUSPECTED ADVERSE REACTIONS, contact Fera Pharmaceuticals, LLC at (414) 434-6604, Monday-Friday 9am-5pm EST or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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