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Hydrocortisone acetate

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Overview

What is Neomed Pharmaceutical?

Hydrocortisone acetate is a corticosteroid designed chemically as pregn-4-ene 3, 20-dione, 21- (acetyloxy)-11, 17-dihydroxy––(11 β) with the following structural formula:

Each rectal suppository contains hydrocortisone acetate, USP 25 mg in a specially blended hydrogenated vegetable oil base.



What does Neomed Pharmaceutical look like?



What are the available doses of Neomed Pharmaceutical?

Sorry No records found.

What should I talk to my health care provider before I take Neomed Pharmaceutical?

Sorry No records found

How should I use Neomed Pharmaceutical?

Hydrocortisone suppositories are indicated for use in:

For Rectal administration.

OPENING INSTRUCTIONS

Avoid excessive handling of the suppository which is designed to melt at body temperature. Insert suppository into the rectum with gentle pressure, pointed end first. Insert one suppository in the rectum twice daily, morning and night for two weeks, in nonspecific proctitis. In more severe cases, one suppository three times a day or two suppositories twice daily. In factitial proctitis, the recommended duration of therapy is six to eight weeks or less, according to the response of the individual case.

All prescription substitutions and/or recommendations using this product shall be made subject to state and federal statutes as applicable.

PLEASE NOTE: This is not an Orange Book product and has not been subjected to FDA therapeutic or other equivalency testing. No representation is made as to generic status or bio equivalency. Each person recommending a prescription substitution using this product shall make such recommendation based on his/her professional knowledge and opinion, upon evaluating the active ingredients, inactive ingredients, excipients and chemical information provided herein.


What interacts with Neomed Pharmaceutical?

Sorry No Records found


What are the warnings of Neomed Pharmaceutical?

Sorry No Records found


What are the precautions of Neomed Pharmaceutical?

Sorry No Records found


What are the side effects of Neomed Pharmaceutical?

Sorry No records found


What should I look out for while using Neomed Pharmaceutical?

Hydrocortisone suppositories are contraindicated in those patients having a history of hypersensitivity to hydrocortisone acetate or any of the components.


What might happen if I take too much Neomed Pharmaceutical?

If signs and symptoms of systemic over dosage occur, discontinue use.


How should I store and handle Neomed Pharmaceutical?

Hydrocortisone acetate suppositories 25mg are off-white, smooth surfaced and bullet shaped with one pointed end.Box of 24 suppositories, NDC 70898-204-24Hydrocortisone acetate suppositories 25mg are off-white, smooth surfaced and bullet shaped with one pointed end.Box of 24 suppositories, NDC 70898-204-24


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

In normal subjects, about 26% of hydrocortisone acetate is absorbed when the suppository is applied to the rectum. Absorption of hydrocortisone acetate may vary across abraded or inflamed surfaces. Topical steroids are primarily effective because of their anti-inflammatory, anti-pruritic and vasoconstrictive action.

Non-Clinical Toxicology
Hydrocortisone suppositories are contraindicated in those patients having a history of hypersensitivity to hydrocortisone acetate or any of the components.

Ketoconazole is mainly metabolized through CYP3A4. Other substances that either sharethis metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of ketoconazole. Similarly, ketoconazole may modify the pharmacokinetics of other substances that share this metabolic pathway. Ketoconazole is a potent CYP3A4 inhibitor and a P-glycoprotein inhibitor. When using concomitant medication, the corresponding label should be consulted for information on the route of metabolism and the possible need to adjust dosages.

Interaction studies have only been performed in adults. The relevance of the results from these studies in pediatric patients is unknown.

Do not use Hydrocortisone suppositories unless adequate proctologic examination is made. If irritation develops, the product should be discontinued and appropriate therapy instituted. In the presence of an infection, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, Hydrocortisone suppository should be discontinued until the infection has been adequately controlled.

The following local adverse reactions have been reported with corticosteroid suppositories; burning, itching, irritation, dryness, folliculitis, hypopigmentation, allergic contact dermatitis, secondary infection.

To report suspected adverse reactions,Contact NEOMED pharmaceutical or www.fda.gov/medwatch

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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