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Neurontin
Overview
What is Neurontin?
The active ingredient in NEURONTIN capsules, tablets, and oral solution is gabapentin, which has the chemical name 1-(aminomethyl)cyclohexaneacetic acid.
The molecular formula of gabapentin is CHNO and the molecular weight is 171.24. The structural formula of gabapentin is:
Gabapentin is a white to off-white crystalline solid with a pK of 3.7 and a pK of 10.7. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is –1.25.
Each NEURONTIN capsule contains 100 mg, 300 mg, or 400 mg of gabapentin and the following inactive ingredients: lactose, cornstarch, talc, gelatin, titanium dioxide, FD&C Blue No. 2, yellow iron oxide (300 mg and 400 mg only), and red iron oxide (400 mg only).
Each NEURONTIN tablet contains 600 mg or 800 mg of gabapentin and the following inactive ingredients: poloxamer 407, copovidone, cornstarch, magnesium stearate, hydroxypropyl cellulose, talc, and candelilla wax
NEURONTIN oral solution contains 250 mg of gabapentin per 5 mL (50 mg per mL) and the following inactive ingredients: glycerin, xylitol, purified water, and artificial cool strawberry anise flavor.
What does Neurontin look like?
What are the available doses of Neurontin?
Capsules
Tablets
Oral solution: 250 mg per 5 mL (50 mg per mL), clear colorless to slightly yellow solution
What should I talk to my health care provider before I take Neurontin?
How should I use Neurontin?
NEURONTIN is indicated for:
In adults with postherpetic neuralgia, NEURONTIN may be initiated on Day 1 as a single 300 mg dose, on Day 2 as 600 mg/day (300 mg two times a day), and on Day 3 as 900 mg/day (300 mg three times a day). The dose can subsequently be titrated up as needed for pain relief to a dose of 1800 mg/day (600 mg three times a day). In clinical studies, efficacy was demonstrated over a range of doses from 1800 mg/day to 3600 mg/day with comparable effects across the dose range; however, in these clinical studies, the additional benefit of using doses greater than 1800 mg/day was not demonstrated.
What interacts with Neurontin?
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What are the warnings of Neurontin?
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What are the precautions of Neurontin?
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What are the side effects of Neurontin?
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What should I look out for while using Neurontin?
NEURONTIN is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
What might happen if I take too much Neurontin?
A lethal dose of gabapentin was not identified in mice and rats receiving single oral doses as high as 8000 mg/kg. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, sedation, hypoactivity, or excitation.
Acute oral overdoses of NEURONTIN up to 49 grams have been reported. In these cases, double vision, slurred speech, drowsiness, lethargy, and diarrhea were observed. All patients recovered with supportive care. Coma, resolving with dialysis, has been reported in patients with chronic renal failure who were treated with NEURONTIN.
Gabapentin can be removed by hemodialysis. Although hemodialysis has not been performed in the few overdose cases reported, it may be indicated by the patient's clinical state or in patients with significant renal impairment.
If overexposure occurs, call your poison control center at 1-800-222-1222.
How should I store and handle Neurontin?
Store refrigerated between 2°C and 8°C (36°F and 46°F). Handle and dispose of topotecan injection consistent with recommendations for the handling and disposal of hazardous drugs. Protect from light.Sterile, Nonpyrogenic, Preservative-free.Store refrigerated between 2°C and 8°C (36°F and 46°F). Handle and dispose of topotecan injection consistent with recommendations for the handling and disposal of hazardous drugs. Protect from light.Sterile, Nonpyrogenic, Preservative-free.Store refrigerated between 2°C and 8°C (36°F and 46°F). Handle and dispose of topotecan injection consistent with recommendations for the handling and disposal of hazardous drugs. Protect from light.Sterile, Nonpyrogenic, Preservative-free.NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:NEURONTIN (gabapentin) capsules, tablets, and oral solution are supplied as follows:100 mg capsules:300 mg capsules:400 mg capsules:600 mg tablets:800 mg tablets:250 mg per 5 mL oral solution:
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Non-Clinical Toxicology
NEURONTIN is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.Many drugs affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to Levothyroxine Sodium Tablets, USP. In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and action of other drugs. A listing of drug-thyroidal axis interactions is contained in Table 2.
The list of drug-thyroidal axis interactions in Table 2 may not be comprehensive due to the introduction of new drugs that interact with the thyroidal axis or the discovery of previously unknown interactions. The prescriber should be aware of this fact and should consult appropriate reference sources (e.g., package inserts of newly approved drugs, medical literature) for additional information if a drug-drug interaction with levothyroxine is suspected.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), also known as multiorgan hypersensitivity, has occurred with NEURONTIN. Some of these reactions have been fatal or life-threatening. DRESS typically, although not exclusively, presents with fever, rash, and/or lymphadenopathy, in association with other organ system involvement, such as hepatitis, nephritis, hematological abnormalities, myocarditis, or myositis sometimes resembling an acute viral infection. Eosinophilia is often present. This disorder is variable in its expression, and other organ systems not noted here may be involved.
It is important to note that early manifestations of hypersensitivity, such as fever or lymphadenopathy, may be present even though rash is not evident. If such signs or symptoms are present, the patient should be evaluated immediately. NEURONTIN should be discontinued if an alternative etiology for the signs or symptoms cannot be established.
The following serious adverse reactions are discussed in greater detail in other sections:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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