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4% Sodium Bicarbonate Additive Solution

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Overview

What is Neut?

To adjust acidic parenteral solutions to a more nearly neutral pH.



What does Neut look like?



What are the available doses of Neut?

Sorry No records found.

What should I talk to my health care provider before I take Neut?

Sorry No records found

How should I use Neut?

Neut (4% sodium bicarbonate additive solution) is indicated for use asa an additive to raise the pH of acid solutions administered intravenously to reduce the incidence of chemical phlebitis and patient discomfort due to vein irritation at or near the site of infusion.

One vial (5 mL) of Neut added to a liter (1000 mL) of any of the following Hospira parenteral solutions will increase the pH to a more physiologic range. Specific pH may vary slightly from lot to lot.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

Addition of one vial of Neut to one-half liter (500 mL) is recommended to achieve a more physiologic pH of the following Hospira parenteral solutions:

When medications are added to intravenous solutions, the resultant admixtures may or may not be compatible in solutions containing Neut (4% sodium bicarbonate additive solution).

Following is a list of medications each added to one liter of 5% Dextrose Injection, USP (D5-W) classified according to their effect with Neut (4% sodium bicarbonate additive solution).

It should be noted that the admixtures were evaluated for physical compatibility, not for pharmacological compatibility. It, therefore, would be erroneous to circumvent medical judgment which must be involved in administering any solution that appears to be compatible on the basis of having no visible haze or precipitate. The inclusion of drugsin this study of their compatibility in solution does not imply their therapeutic usefulness or safety. This matter remains the judgment of the prescribing physician.


What interacts with Neut?

Sorry No Records found


What are the warnings of Neut?

Sorry No Records found


What are the precautions of Neut?

Sorry No Records found


What are the side effects of Neut?

Sorry No records found


What should I look out for while using Neut?

Not for use as a systemic alkalizer.

None known.


What might happen if I take too much Neut?

None known.


How should I store and handle Neut?

Neut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USANeut (4% sodium bicarbonate additive solution) is supplied in partial-fill single-dose containers.5 mL fliptop vial (list No. 6609).Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Revised: November, 2004©Hospira 2004EN-0545HOSPIRA, INC., LAKE FOREST, IL 60045 USAPrinted in USA


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The acid pH of most intrvenous solutions has been implicated as a factor in the production of postinfusion (chemical) phlebitis not caused by obvious infection. Vein irritation, with local redness and tenderness near the site of venipuncture or along the course of a vein, appears to be realated to the nature of the substances in the infusion and the speed (insufficient dilution by the bloodstream) as well as the duration (prolonged exposure of the intima) of infusion. Other contributing factors include the size of the vein used for venipuncture, shape or method of insertion of the venipuncture needle, the use or type of indwelling catheter, infection at the infusion site and the age of the patient (children and females seem to be more susceptible).

The pH of commonly used dextrose infustion solutions ranges from 3.5 to 6.5. Other commonly used solutions also may have an acid pH. Since non-neutral parenteral solutions with a low (acid) pH are known to cause chemical irritation of tissues, it is not surprising that chemical phlebitis may occur as a complication with their infusion. Vein irritation is most likely when the duration of infusion i slong or when hemodilution is minimized by a large needle in a small vein.

The amount of sodium bicarbonate recommended as an additive to neutralize acid parenteral solutions is too small to exert a clinicallly significant increase in electrolyte content.

Non-Clinical Toxicology
Not for use as a systemic alkalizer.

None known.

High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone.

Do not administer unless solution is clear and seal in intact. Discard unused portion.

Solutions prepared with Neut (4% sodium bicarbonate additive solution) should be administered promptly. When introducing additives, use aseptic technique, mix thoroughly and do not store.

When Neut is added to Hospira solutions, the compatibility of these solutions with other drugs may be altered. (See section on COMPATIBILITY, etc., for listing of additives tested with Neut added D5-W.)

Raising the pH of I.V. fluids with Neut will only reduce the incidence of chemical irritation caused by the infusate; it will not diminish any foreign body effects caused by the needle or catheter.

None known.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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