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sorafenib
Overview
What is Nexavar?
NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib.
Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2-methylpyridine-2-carboxamide 4-methylbenzenesulfonate and its structural formula is:
Sorafenib tosylate is a white to yellowish or brownish solid with a molecular formula of CHClFNO x CHOS and a molecular weight of 637.0 g/mole. Sorafenib tosylate is practically insoluble in aqueous media, slightly soluble in ethanol and soluble in PEG 400.
Each red, round NEXAVAR film-coated tablet contains sorafenib tosylate (274 mg) equivalent to 200 mg of sorafenib and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, polyethylene glycol, titanium dioxide and ferric oxide red.
What does Nexavar look like?
What are the available doses of Nexavar?
200 mg Tablets ()
What should I talk to my health care provider before I take Nexavar?
How should I use Nexavar?
NEXAVAR is indicated for the treatment of patients with unresectable hepatocellular carcinoma (HCC).
The recommended daily dose of NEXAVAR is 400 mg (2 x 200 mg tablets) taken twice daily without food (at least 1 hour before or 2 hours after a meal). Treatment should continue until the patient is no longer clinically benefiting from therapy or until unacceptable toxicity occurs.
What interacts with Nexavar?
Sorry No Records found
What are the warnings of Nexavar?
Sorry No Records found
What are the precautions of Nexavar?
Sorry No Records found
What are the side effects of Nexavar?
Sorry No records found
What should I look out for while using Nexavar?
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What might happen if I take too much Nexavar?
There is no specific treatment for NEXAVAR overdose.
The highest dose of NEXAVAR studied clinically is 800 mg twice daily. The adverse reactions observed at this dose were primarily diarrhea and dermatologic. No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals.
In cases of suspected overdose, NEXAVAR should be withheld and supportive care instituted.
How should I store and handle Nexavar?
Store at 20-25°C (68-77°F) [See USP]. Protect from light.NEXAVAR tablets are supplied as round, biconvex, red film-coated tablets, debossed with the “Bayer cross” on one side and “200” on the other side, each containing sorafenib tosylate equivalent to 200 mg of sorafenib. Storage Store at 25° C (77°F); excursions permitted to 15–30° C (59–86° F) (see USP controlled room temperature). Store in a dry place. NEXAVAR tablets are supplied as round, biconvex, red film-coated tablets, debossed with the “Bayer cross” on one side and “200” on the other side, each containing sorafenib tosylate equivalent to 200 mg of sorafenib. Storage Store at 25° C (77°F); excursions permitted to 15–30° C (59–86° F) (see USP controlled room temperature). Store in a dry place. NEXAVAR tablets are supplied as round, biconvex, red film-coated tablets, debossed with the “Bayer cross” on one side and “200” on the other side, each containing sorafenib tosylate equivalent to 200 mg of sorafenib. Storage Store at 25° C (77°F); excursions permitted to 15–30° C (59–86° F) (see USP controlled room temperature). Store in a dry place.
