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Nexplanon

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Overview

What is Nexplanon?

NEXPLANON is a radiopaque, progestin-only, soft, flexible implant preloaded in a sterile, disposable applicator for subdermal use. The implant is white/off-white, non-biodegradable and 4 cm in length with a diameter of 2 mm (see ). Each implant consists of an ethylene vinyl acetate (EVA) copolymer core, containing 68 mg of the synthetic progestin etonogestrel, barium sulfate (radiopaque ingredient), and may also contain magnesium stearate, surrounded by an EVA copolymer skin. Once inserted subdermally, the release rate is 60-70 mcg/day in week 5-6 and decreases to approximately 35-45 mcg/day at the end of the first year, to approximately 30-40 mcg/day at the end of the second year, and then to approximately 25-30 mcg/day at the end of the third year. NEXPLANON is a progestin-only contraceptive and does not contain estrogen. NEXPLANON does not contain latex.

Etonogestrel [13-Ethyl-17-hydroxy-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3-one], structurally derived from 19-nortestosterone, is the synthetic biologically active metabolite of the synthetic progestin desogestrel. It has a molecular weight of 324.46 and the following structural formula (Figure 19).



What does Nexplanon look like?



What are the available doses of Nexplanon?

NEXPLANON consists of a single, radiopaque, rod-shaped implant, containing 68 mg etonogestrel, pre-loaded in the needle of a disposable applicator. ()

What should I talk to my health care provider before I take Nexplanon?

How should I use Nexplanon?

NEXPLANON is indicated for use by women to prevent pregnancy.

The efficacy of NEXPLANON does not depend on daily, weekly or monthly administration.

All healthcare providers should receive instruction and training prior to performing insertion and/or removal of NEXPLANON.

A single NEXPLANON implant is inserted subdermally in the upper arm. To reduce the risk of neural or vascular injury, the implant should be inserted at the inner side of the non-dominant upper arm about 8-10 cm (3-4 inches) above the medial epicondyle of the humerus. The implant should be inserted subdermally just under the skin, avoiding the sulcus (groove) between the biceps and triceps muscles and the large blood vessels and nerves that lie there in the neurovascular bundle deeper in the subcutaneous tissues. An implant inserted more deeply than subdermally (deep insertion) may not be palpable and the localization and/or removal can be difficult or impossible NEXPLANON must be inserted by the expiration date stated on the packaging. NEXPLANON is a long-acting (up to 3 years), reversible, hormonal contraceptive method. The implant must be removed by the end of the third year and may be replaced by a new implant at the time of removal, if continued contraceptive protection is desired.


What interacts with Nexplanon?

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What are the warnings of Nexplanon?

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What are the precautions of Nexplanon?

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What are the side effects of Nexplanon?

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What should I look out for while using Nexplanon?

NEXPLANON should not be used in women who have


What might happen if I take too much Nexplanon?

Overdosage may result if more than one implant is inserted. In case of suspected overdose, the implant should be removed.


How should I store and handle Nexplanon?

Store NEXPLANON (etonogestrel implant) Radiopaque at 25ºC (77ºF); excursions permitted to 15-30ºC (59-86ºF) [see USP Controlled Room Temperature]. Avoid storing NEXPLANON at temperatures above 30ºC (86ºF).Product: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLEProduct: 63629-2924NDC: 63629-2924-6 12 CAPSULE in a BOTTLENDC: 63629-2924-7 120 CAPSULE in a BOTTLENDC: 63629-2924-2 20 CAPSULE in a BOTTLENDC: 63629-2924-4 21 CAPSULE in a BOTTLENDC: 63629-2924-5 28 CAPSULE in a BOTTLENDC: 63629-2924-1 30 CAPSULE in a BOTTLENDC: 63629-2924-3 40 CAPSULE in a BOTTLENDC: 63629-2924-0 16 CAPSULE in a BOTTLENDC: 63629-2924-8 14 CAPSULE in a BOTTLENDC: 63629-2924-9 45 CAPSULE in a BOTTLE


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The contraceptive effect of NEXPLANON is achieved by suppression of ovulation, increased viscosity of the cervical mucus, and alterations in the endometrium.

Non-Clinical Toxicology
NEXPLANON should not be used in women who have

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.

Antagonism has been demonstrated between clindamycin and erythromycin . Because of possible clinical significance, these two drugs should not be administered concurrently.

The following information is based on experience with the etonogestrel implants (IMPLANON and/or NEXPLANON), other progestin-only contraceptives, or experience with combination (estrogen plus progestin) oral contraceptives.

The following adverse reactions reported with the use of hormonal contraception are discussed elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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