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NITHIODOTE

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Overview

What is NITHIODOTE?

Sodium nitrite, one of the active ingredients in NITHIODOTE has the chemical name nitrous acid sodium salt. The chemical formula is NaNO and the molecular weight is 69.0. Sodium thiosulfate, the second active ingredient in NITHIODOTE has the chemical name thiosulfuric acid, disodium salt, pentahydrate. The chemical formula is NaSO∙ 5HO and the molecular weight is 248.17. The structural formulae are:

Structure of Sodium Nitrite

Structure of Sodium Thiosulfate Pentahydrate

NITHIODOTE is a cyanide antidote which contains one 10 mL glass vial of a 3% solution of sodium nitrite injection and one 50 mL glass vial containing a 25% solution of sodium thiosulfate injection.

Sodium nitrite injection is a sterile aqueous solution and is intended for intravenous injection. Each vial contains 300 mg of sodium nitrite in 10 mL solution (30 mg/mL). Sodium nitrite injection is a clear solution with a pH between 7.0 and 9.0.

Sodium thiosulfate injection is a sterile aqueous solution and is intended for intravenous injection. Each vial contains 12.5 grams of sodium thiosulfate in 50 mL solution (250 mg/mL). Each mL also contains 2.8 mg boric acid and 4.4 mg of potassium chloride. The pH of the solution is adjusted with boric acid and/or sodium hydroxide. Sodium thiosulfate injection is a clear solution with a pH between 7.5 and 9.0.



What does NITHIODOTE look like?



What are the available doses of NITHIODOTE?

NITHIODOTE consists of:

What should I talk to my health care provider before I take NITHIODOTE?

How should I use NITHIODOTE?

NITHIODOTE is indicated for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. When the diagnosis of cyanide poisoning is uncertain, carefully weigh the potentially life-threatening risks associated with NITHIODOTE against the potential benefits, especially if the patient is not in extremis.

If clinical suspicion of cyanide poisoning is high, administer without delay and in conjunction with appropriate airway, ventilatory, and circulatory support. ()

The expert advice of a regional poison control center may be obtained by calling 1-800-222-1222. ()


What interacts with NITHIODOTE?

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What are the warnings of NITHIODOTE?

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What are the precautions of NITHIODOTE?

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What are the side effects of NITHIODOTE?

Sorry No records found


What should I look out for while using NITHIODOTE?

None

Sodium nitrite can cause serious adverse reactions and death in humans, even at doses less than twice the recommended therapeutic dose. Sodium nitrite causes hypotension and methemoglobin formation, which diminishes oxygen carrying capacity. Hypotension and methemoglobin formation can occur concurrently or separately. Because of these risks, sodium nitrite should be used to treat acute life-threatening cyanide poisoning and be used with caution in patients where the diagnosis of cyanide poisoning is uncertain

Patients should be closely monitored to ensure adequate perfusion and oxygenation during treatment with sodium nitrite.

Alternative therapeutic approaches should be considered in patients known to have diminished oxygen or cardiovascular reserve (e.g. smoke inhalation victims, pre-existing anemia, cardiac or respiratory compromise), and those at higher risk of developing methemoglobinemia (e.g., congenital methemoglobin reductase deficiency) as they are at greater risk for potentially life-threatening adverse events related to the use of sodium nitrite

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What might happen if I take too much NITHIODOTE?


How should I store and handle NITHIODOTE?

Store at 20-25° C (68-77° F); excursions permitted to 15-30° C (59-86° F).  See USP Controlled Room Temperature.  Avoid excess heat, above 40°C (104°F)Each NITHIODOTE carton (NDC 60267-812-00) consists of the following: