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hydrocortisone acetate and pramoxine hydrochloride

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Overview

What is Novacort?

Each gram of NOVACORT contains 2.0% (20 mg) Hydrocortisone Acetate and 1.0% (10 mg) Pramoxine Hydrochloride (HCI). Other Ingredients: Aloe Polysaccharide, Benzyl Alcohol, Biopeptide CL, Cetyl Alcohol, Dimethicone, Dimethyl Isosorbide, Glycerin, Glyceryl Stearate, Hydroxypropyl Methylcellulose, PEG-100 Stearate, Phenoxyethanol, Poloxamer 407, Propylene Glycol, Purified Water, Stearoxytrimethylsilane, Stearyl Alcohol, and Witch Hazel Distillate.

Hydrocortisone A

cetate

Pramoxine H

ydrochloride

CHNO• HCI] with a molecular weight of 329.87. Chemically, Pramoxine Hydrochloride is represented by the following structural formula: 



What does Novacort look like?



What are the available doses of Novacort?

Sorry No records found.

What should I talk to my health care provider before I take Novacort?

Sorry No records found

How should I use Novacort?

Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Topical corticosteroids are generally applied to the affected area as a thin film three to four times daily (depending on the severity of the condition) in accordance with physician’s directions or as directed otherwise by a physician. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. Use with occlusive dressings or diapers should be under physician supervision.


What interacts with Novacort?

Sorry No Records found


What are the warnings of Novacort?

Sorry No Records found


What are the precautions of Novacort?

Sorry No Records found


What are the side effects of Novacort?

Sorry No records found


What should I look out for while using Novacort?

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.


What might happen if I take too much Novacort?

Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects. (See .)


How should I store and handle Novacort?

NDC #69646-704-26 29.0 gram gel tubeNDC #69646-704-02 2.0 gram gel sample – not for resaleNDC #69646-704-08 10-count carton of 2.0 gram gel sample packs - not for resaleNDC #69646-704-01 1.0 gram gel sample – not for resaleNDC #69646-704-38 10-count carton of 1.0 gram gel sample packs – not for resaleNDC # 69646-704-03: 2.0 gram gel tube sample – not for resaleNDC # 69646-704-11: 10-count carton of 2.0 gram gel sample tubes – not for resaleEach 1.0 gram gel pack contains multiple doses depending on the surface area treated.Each 2.0 gram gel pack contains multiple doses depending on the surface area treated.NDC #69646-704-26 29.0 gram gel tubeNDC #69646-704-02 2.0 gram gel sample – not for resaleNDC #69646-704-08 10-count carton of 2.0 gram gel sample packs - not for resaleNDC #69646-704-01 1.0 gram gel sample – not for resaleNDC #69646-704-38 10-count carton of 1.0 gram gel sample packs – not for resaleNDC # 69646-704-03: 2.0 gram gel tube sample – not for resaleNDC # 69646-704-11: 10-count carton of 2.0 gram gel sample tubes – not for resaleEach 1.0 gram gel pack contains multiple doses depending on the surface area treated.Each 2.0 gram gel pack contains multiple doses depending on the surface area treated.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Topical corticosteroids share anti-inflammatory, anti-pruritic, and vasoconstrictive actions.

The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

Pramoxine Hydrochloride is a topical anesthetic agent which provides temporary relief from itching and pain. It acts by stabilizing the neuronal membrane of the nerve endings with which it comes into contact.

Non-Clinical Toxicology
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

For external use only. Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients. Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.

Therefore, patients receiving a large dose of a potent topical steroid applied over a large surface area and under an occlusive dressing should be evaluated periodically for the evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

Recovery of HPA axis function is usually prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. (See .) Keep out of reach of children.

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. Burning, itching, irritation, and dryness have been reported infrequently following the use of topical corticosteroids.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infections, skin atrophy, striae, and miliaria. Possible local adverse reactions associated with pramoxine include burning and stinging.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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