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Ocupress
Overview
What is Ocupress?
Ocupress (carteolol hydrochloride ophthalmic solution), 1%, is a nonselective beta-adrenoceptor blocking agent for ophthalmic use.
The chemical name for carteolol hydrochloride is (±)–5–[3–[(1,1–dimethylethyl) amino]–2 hydroxypropoxy]–3, 4–dihydro–2(1)–quinolinone monohydrochloride. The structural formula is as follows:
Each mL contains 10 mg carteolol HCl and the inactive ingredients – Benzalkonium chloride 0.05 mg (0.005%) as a preservative; sodium chloride; sodium phosphate, dibasic; sodium phosphate, monobasic; and water for injection, USP. The product has a pH of 6.2 to 7.2
What does Ocupress look like?
What are the available doses of Ocupress?
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What should I talk to my health care provider before I take Ocupress?
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How should I use Ocupress?
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What interacts with Ocupress?
Sorry No Records found
What are the warnings of Ocupress?
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What are the precautions of Ocupress?
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What are the side effects of Ocupress?
Sorry No records found
What should I look out for while using Ocupress?
Ocupress Ophthalmic Solution is contraindicated in those individuals with bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease (see WARNINGS); sinus bradycardia; second- and third-degree atrioventricular block; overt cardiac failure (see WARNINGS); cardiogenic shock; or hypersensitivity to any component of this product.
Ocupress Ophthalmic Solution has not been detected in plasma following ocular instillation. However, as with other topically applied ophthalmic preparations, Ocupress may be absorbed systemically. The same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported with topical application of beta-adrenergic blocking agents (see CONTRAINDICATIONS).
What might happen if I take too much Ocupress?
No specific information on emergency treatment of overdosage in humans is available. Should accidental ocular overdosage occur, flush eye(s) with water or normal saline. The most common effects expected with overdosage of a beta-adrenergic blocking agent are bradycardia, bronchospasm, congestive heart failure and hypotension.
In case of ingestion, treatment with Ocupress should be discontinued and gastric lavage considered. The patient should be closely observed and vital signs carefully monitored. The prolonged effects of carteolol must be considered when determining the duration of corrective therapy. On the basis of the pharmacologic profile, the following additional measures should be considered as appropriate:
Symptomatic Sinus Bradycardia or Heart Block:
Bronchospasm:
Congestive Heart Failure:
Hypotension:
How should I store and handle Ocupress?
Ocupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-BOcupress Ophthalmic Solution, 1%, is supplied as a sterile ophthalmic solution in plastic dispenser bottles of 5 mL (NDC 58768-001-01), 10 mL (NDC 58768-001-02) and 15 mL (NDC 58768-001-04).Store at 15° to 25°C (59° to 77°F) (room temperature) and protect from light.Rx OnlyLicensed under U.S. Patent Nos. 3910924 and 4309432.Made in Canada by:CIBA Vision Sterile Mfg.,Mississauga, Ontario L5N 2X5For: Novartis Ophthalmics, Duluth, Georgia 30097I6138-B
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Carteolol HCl is a nonselective beta-adrenergic blocking agent with associated intrinsic sympathomimetic activity and without significant membrane-stabilizing activity.
Ocupress (carteolol HCl) reduces normal and elevated intraocular pressure (IOP) whether or not accompanied by glaucoma. The exact mechanism of the ocular hypotensive effect of beta-blockers has not been definitely demonstrated.
In general, beta-adrenergic blockers reduce cardiac output in patients in good and poor cardiovascular health. In patients with severe impairment of myocardial function, beta-blockers may inhibit the sympathetic stimulation necessary to maintain adequate cardiac function. Beta-adrenergic blockers may also increase airway resistance in the bronchi and bronchioles due to unopposed parasympathetic activity.
Given topically twice daily in controlled domestic clinical trials ranging from 1.5 to 3 months, Ocupress produced a median percent reduction of IOP 22% to 25%. No significant effects were noted on corneal sensitivity, tear secretion, or pupil size.
Non-Clinical Toxicology
Ocupress Ophthalmic Solution is contraindicated in those individuals with bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease (see WARNINGS); sinus bradycardia; second- and third-degree atrioventricular block; overt cardiac failure (see WARNINGS); cardiogenic shock; or hypersensitivity to any component of this product.Ocupress Ophthalmic Solution has not been detected in plasma following ocular instillation. However, as with other topically applied ophthalmic preparations, Ocupress may be absorbed systemically. The same adverse reactions found with systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported with topical application of beta-adrenergic blocking agents (see CONTRAINDICATIONS).
Ocupress should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally, because of the potential for additive effects on systemic beta-blockade.
Array
Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension.
Ocupress Ophthalmic Solution should be used with caution in patients with known hypersensitivity to other beta-adrenoceptor blocking agents.
Use with caution in patients with known diminished pulmonary function.
In patients with angle-closure glaucoma, the immediate objective of treatment is to reopen the angle. This requires constricting the pupil with a miotic. Ocupress has little or no effect on the pupil. When Ocupress is used to reduce elevated intraocular pressure in angle-closure glaucoma, it should be used with a miotic and not alone.
The following adverse reactions have been reported in clinical trials with Ocupress Ophthalmic Solution:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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