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Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tablet 40/10/25 mg

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Overview

What is Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets provided as a tablet for oral administration, are a fixed combination of olmesartan medoxomil (ARB), amlodipine (CCB), and hydrochlorothiazide (thiazide diuretic).

Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract.

The olmesartan medoxomil component of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets is chemically described as 2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1- methylethyl)-2-propyl-1-[1-tetrazol-5-ylphenyl)benzyl]imidazole-5-carboxylate, cyclic 2,3-carbonate.  Its empirical formula is CHNO.

The amlodipine besylate component of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets is chemically described as 3-ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is CHCINO•CHOS.

The hydrochlorothiazide component of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets is chemically described as 6-chloro-3,4-dihydro-2-1,2,4-benzo-thiazidiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is CHCINOS.

The structural formula for olmesartan medoxomil, USP is:

The structural formula for amlodipine besylate, USP is:

The structural formula for hydrochlorothiazide, USP is:

Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP a white to light yellowish-white powder or crystalline powder, amlodipine besylate, USP a white to off-white crystalline powder, and hydrochlorothiazide, USP a white or practically white, crystalline powder. The molecular weights of olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide are 558.6, 567.1, and 297.7, respectively. Olmesartan medoxomil is practically insoluble in water and sparingly soluble in methanol. Amlodipine besylate is slightly soluble in water and sparingly soluble in ethanol. Hydrochlorothiazide is slightly soluble in water but freely soluble in sodium hydroxide solution.

Each tablet of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets also contains the following inactive ingredients: colloidal silicone dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, maize starch, pregelatinized maize starch, silicified microcrystalline cellulose, and talc. The color coating contains opadry II pink (20/5/12.5 mg, 40/10/12.5 mg and 40/10/25 mg tablets), and opadry II yellow (40/5/12.5 mg and 40/5/25 mg tablets).

The color coating material contains the following ingredients.



What does Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg look like?



What are the available doses of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are available in the following strength combinations:

What should I talk to my health care provider before I take Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

How should I use Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

 

 Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets is not indicated for initial therapy.

  Dose once daily. Dosage may be increased after 2 weeks to a maximum dose of 40 /10 /25 mg once daily (2).

  Dose selection should be individualized based on previous therapy (2).


What interacts with Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Sorry No Records found


What are the warnings of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Sorry No Records found


What are the precautions of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Sorry No Records found


What are the side effects of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Sorry No records found


What should I look out for while using Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

  Anuria: Hypersensitivity to sulfonamide-derived drugs (4).

  Do not co-administer aliskiren with olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in patients with diabetes (4).


What might happen if I take too much Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

There is no information on overdosage with olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in humans.

Olmesartan medoxomil.

Amlodipine.

Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia.  In humans, experience with intentional overdosage of amlodipine is limited.

If massive overdose should occur, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential. Should hypotension occur, cardiovascular support including elevation of the extremities and the judicious administration of fluids should be initiated. If hypotension remains unresponsive to these conservative measures, administration of vasopressors (such as phenylephrine) should be considered with attention to circulating volume and urine output. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. As amlodipine is highly protein bound, hemodialysis is not likely to be of benefit.

Hydrochlorothiazide.


How should I store and handle Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg?

Keep out of reach of children.Fluvoxamine maleate tablets, USP should be protected from high humidity and stored at 20°C to 25°C (68°F to 77°F); excursions permitted from 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Keep out of reach of children.Fluvoxamine maleate tablets, USP should be protected from high humidity and stored at 20°C to 25°C (68°F to 77°F); excursions permitted from 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Keep out of reach of children.Fluvoxamine maleate tablets, USP should be protected from high humidity and stored at 20°C to 25°C (68°F to 77°F); excursions permitted from 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature]. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets contain olmesartan medoxomil, USP, amlodipine besylate, USP at a dose equivalent to 5 or 10 mg amlodipine, and hydrochlorothiazide, USP in the strengths described below.Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are differentiated by tablet color/size. Olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets are supplied for oral administration in the following strength and package configurations:20/5/12.5 mg tablets are orange white colored, round, biconvex, film coated debossed with '26' on one side and plain on the other side.Bottles of 30                           NDC 13668-397-30Bottles of 90                           NDC 13668-397-90Bottles of 500                         NDC 13668-397-05                                    100 Unit dose Tablets             NDC 13668-397-7440/5/12.5 mg tablets are light yellow to yellow colored, round, biconvex, film coated debossed with '1386' on one side and plain on the other side.Bottles of 30                           NDC 13668-386-30Bottles of 90                           NDC 13668-386-90Bottles of 500                         NDC 13668-386-05                                    100 Unit dose Tablets              NDC 13668-386-7440/5/25 mg tablets are light yellow to yellow colored, oval shaped, biconvex, film coated debossed with '1385' on one side and plain on the other side.Bottles of 30                           NDC 13668-385-30Bottles of 90                           NDC 13668-385-90Bottles of 500                         NDC 13668-385-05                                    100 Unit dose Tablets              NDC 13668-385-7440/10/12.5 mg tablets are grayish red colored, round, biconvex, film coated, debossed with '1383' on one side and plain on the other side.Bottles of 30                           NDC 13668-383-30Bottles of 90                           NDC 13668-383-90Bottles of 500                         NDC 13668-383-05                                    100 Unit dose Tablets              NDC 13668-383-7440/10/25 mg tablets are grayish red colored, oval shaped, biconvex, film coated, debossed with '1382' on one side and plain on the other side.Bottles of 30                           NDC 13668-382-30Bottles of 90                           NDC 13668-382-90Bottles of 500                         NDC 13668-382-05                                    100 Unit dose Tablets              NDC 13668-382-74 Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

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Clinical Pharmacology

The active ingredients of olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets target three separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; olmesartan medoxomil blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume.  For a more detailed description of the mechanisms of action for each individual component, see below.

Olmesartan medoxomil.

An AT receptor is found also in many tissues, but this receptor is not known to be associated with cardiovascular homeostasis.  Olmesartan has more than a 12,500-fold greater affinity for the AT receptor than for the AT receptor.

Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is a mechanism of many drugs used to treat hypertension. Angiotensin-converting enzyme inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE.  Because olmesartan does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known.

Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and circulating angiotensin II levels do not overcome the effect of olmesartan on blood pressure.

Amlodipine

in vitro

Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

Hydrochlorothiazide

The mechanism of the antihypertensive effect of thiazides is not fully understood.

Non-Clinical Toxicology
  Anuria: Hypersensitivity to sulfonamide-derived drugs (4).

  Do not co-administer aliskiren with olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets in patients with diabetes (4).

In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone. The contribution of each of the treatments to this adverse reaction is unknown, but the possibility of a drug interaction cannot be excluded. Drugs possessing beta-blocking properties can blunt the bronchodilator effect of beta-receptor agonist drugs in patients with bronchospasm; therefore, doses greater than the normal antiasthmatic dose of beta-agonist bronchodilator drugs may be required.  Cimetidine has been shown to increase the bioavailability of labetalol HCl. Since this could be explained either by enhanced absorption or by an alteration of hepatic metabolism of labetalol HCl, special care should be used in establishing the dose required for blood pressure control in such patients.

Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl. During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure. The anesthesiologist should be informed when a patient is receiving labetalol HCl.

Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect. If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.

Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate.Concomitant use can increase the risk of bradycardia.





Pregnancy Category D

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue olmesartan medoxomil, amlodipine and hydrochlorothiazide tablets as soon as possible see

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).