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clobetasol propionate

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Overview

What is OLUX?

OLUX (clobetasol propionate) Foam, 0.05%, is a white thermolabile hydroethanolic aerosol foam containing the active ingredient, clobetasol propionate, USP, a synthetic corticosteroid, for topical use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

Clobetasol propionate is 21-chloro-9-fluoro-11ß,17-dihydroxy-16ß-methylpregna-1,4-diene-3,20-dione 17-propionate, with the empirical formula CHCIFO, a molecular weight of 466.97.

The following is the chemical structure:

Clobetasol propionate is a white or almost white crystalline powder, practically insoluble in water.

Each gram of OLUX Foam contains 0.5 mg clobetasol propionate, USP. The foam also contains cetyl alcohol, citric acid, ethanol (60%), polysorbate 60, potassium citrate, propylene glycol, purified water, and stearyl alcohol pressurized with a hydrocarbon (propane/butane) propellant.



What does OLUX look like?



What are the available doses of OLUX?

Olux (clobetasol propionate) Foam, 0.05% contains 0.5 mg of clobetasol propionate, USP per gram.

What should I talk to my health care provider before I take OLUX?

How should I use OLUX?

OLUX Foam is a corticosteroid indicated for treatment of moderate to severe plaque psoriasis of the scalp and mild to moderate plaque psoriasis of non-scalp regions of the body excluding the face and intertriginous areas in patients 12 years and older.

Apply a thin layer of OLUX Foam to the affected skin areas twice daily.

OLUX Foam is a super-high-potency topical corticosteroid; therefore, limit treatment to 2 consecutive weeks. Patients should not use greater than 50 grams per week or more than 21 capfuls per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis

Therapy should be discontinued when control is achieved.

OLUX Foam should not be used with occlusive dressings unless directed by a physician.

OLUX Foam is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

Avoid contact with eyes. Wash hands after each application.

Avoid use on the face, groin, or axillae, or if skin atrophy is present at the treatment site.


What interacts with OLUX?

Sorry No Records found


What are the warnings of OLUX?

Sorry No Records found


What are the precautions of OLUX?

Sorry No Records found


What are the side effects of OLUX?

Sorry No records found


What should I look out for while using OLUX?

None.


What might happen if I take too much OLUX?

Sorry No Records found


How should I store and handle OLUX?

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP].Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.Meloxicam tablets, USP 7.5 mg are yellow coloured, round, biconvex tablets, debossed with "158" on one side and "C" on the other. Meloxicam tablets, USP 15 mg are yellow coloured, round, flat bevelled tablets, debossed with "CIPLA" on one side and "159" on the other. Meloxicam tablets, USP 7.5 mg are available as follows:NDC 69097-158-07                 Bottles of 100                             NDC 69097-158-12                 Bottles of 500                             NDC 69097-158-15                 Bottles of 1000                           Meloxicam tablets, USP 15 mg are available as follows:NDC 69097-159-07                 Bottles of 100                               NDC 69097-159-12                 Bottles of 500                               NDC 69097-159-15                 Bottles of 1000            Storage Store at 20  to 25 C (68  to 77 F) [See USP Controlled Room Temperature]. Keep meloxicam tablets in a dry place. Dispense tablets in a tight container. Keep this and all medications out of the reach of children.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action in corticosteroid-responsive dermatoses is unknown.

Non-Clinical Toxicology
None.





Bumetanide was devoid of mutagenic activity in various strains of when tested in the presence or absence of an metabolic activation system. An 18-month study showed an increase in mammary adenomas of questionable significance in female rats receiving oral doses of 60 mg/kg/day (2000 times a 2-mg human dose). A repeat study at the same doses failed to duplicate this finding.

Reproduction studies were performed to evaluate general reproductive performance and fertility in rats at oral dose levels of 10 mg/kg/day, 30 mg/kg/day, 60 mg/kg/day or 100 mg/kg/day. The pregnancy rate was slightly decreased in the treated animals; however, the differences were small and not statistically significant.

OLUX Foam can cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency. This may occur during treatment or after withdrawal of treatment. Factors that predispose a patient to HPA axis suppression include the use of high-potency steroids, large treatment surface areas, prolonged use, use of occlusive dressings, altered skin barrier, liver failure, and young age. Evaluation for HPA axis suppression may be done by using the adrenocorticotropic hormone (ACTH) stimulation test.

In a trial evaluating the effects of OLUX Foam on the HPA axis, 13 subjects applied OLUX Foam to at least 20% of involved body surface area for 14 days. HPA axis suppression was identified in 5 out of 13 subjects (38%) []

If HPA axis suppression is documented, gradually withdraw the drug, reduce the frequency of application, or substitute with a less potent corticosteroid.

Cushing’s syndrome and hyperglycemia may also occur due to the systemic effects of the topical corticosteroid. These complications are rare and generally occur after prolonged exposure to excessively large doses, especially of high-potency topical corticosteroids.

Pediatric patients may be more susceptible to systemic toxicity due to their larger skin surface to body mass ratios [].

The following adverse reactions are discussed in greater detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).