Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

Clindamycin Phosphate and Benzoyl Peroxide

×

Overview

What is ONEXTON?

ONEXTON Gel is a combination product with two active ingredients in a white to off-white, opaque, smooth, aqueous gel formulation intended for topical use. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

The chemical name for clindamycin phosphate is -(dihydrogen phosphate). The structural formula for clindamycin phosphate is represented below:

Clindamycin phosphate:

Molecular Formula: CHClNOPS          Molecular Weight: 504.97

Benzoyl peroxide is an antibacterial and keratolytic agent. The structural formula for benzoyl peroxide is represented below:

Benzoyl peroxide:

Molecular Formula: CHO          Molecular Weight: 242.23

ONEXTON Gel contains the following inactive ingredients: carbomer 980, potassium hydroxide, propylene glycol, and purified water. Each gram of ONEXTON Gel contains 12 mg (1.2%) clindamycin phosphate, equivalent to 10 mg (1%) clindamycin, and 37.5 mg (3.75%) benzoyl peroxide.



What does ONEXTON look like?



What are the available doses of ONEXTON?

Gel, 1.2%/3.75%

3

What should I talk to my health care provider before I take ONEXTON?

How should I use ONEXTON?

ONEXTON (clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/3.75% is indicated for the topical treatment of acne vulgaris in patients 12 years of age and older.

Before applying ONEXTON Gel, wash the face gently with a mild soap, rinse with warm water, and pat the skin dry. Apply a pea-sized amount of ONEXTON Gel to the face once daily. Avoid the eyes, mouth, lips, mucous membranes, or areas of broken skin.

Use of ONEXTON Gel beyond 12 weeks has not been evaluated.

ONEXTON Gel is not for oral, ophthalmic, or intravaginal use.


What interacts with ONEXTON?

Sorry No Records found


What are the warnings of ONEXTON?

Sorry No Records found


What are the precautions of ONEXTON?

Sorry No Records found


What are the side effects of ONEXTON?

Sorry No records found


What should I look out for while using ONEXTON?

•

4.1

•

4.2


What might happen if I take too much ONEXTON?

Sorry No Records found


How should I store and handle ONEXTON?

Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15 Promethazine Hydrochloride and Codeine Phosphate Syrup contains promethazine hydrochloride, USP 6.25 mg/5 mL, codeine phosphate, USP 10 mg/5 mL and alcohol 7 percent. It is supplied as follows:NDC 12634-907-02 60 mL BottleNDC 12634-907-04 118 mL BottleNDC 12634-907-06 178 mL BottleNDC 12634-907-08 237 mL BottleNDC 12634-907-16 473 mL BottleNDC 12634-907-28 3785 mL BottleNDC 12634-907-32 946 mL BottleStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container as defined in the USP. Repakaged & Distributed by:Apotheca Inc. Phoenix, AZ 85006 Bryan, OH 43506 5981T05 Iss: 03/15


×

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
•

4.1

•

4.2

Systemic absorption of clindamycin has been demonstrated following topical use of clindamycin. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. If significant diarrhea occurs, ONEXTON Gel should be discontinued.

Severe colitis has occurred following oral and parenteral administration of clindamycin with an onset of up to several weeks following cessation of therapy. Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen severe colitis. Severe colitis may result in death.

Studies indicate toxin(s) produced by Clostridia is one primary cause of antibiotic-associated colitis. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Stool cultures for and stool assay for toxin may be helpful diagnostically.

The following adverse reaction is described in more detail in the section of the label:

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

Rate this treatment and share your opinion


Learn about User Reviews

Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

Effectiveness (required)

This medication has worked for me.




Ease of Use (required)

This medication has been easy for me to use.




Satisfaction (required)

Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
×

Tips

Tips

×

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).