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Oseltamivir Phosphate

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Overview

What is Oseltamivir Phosphate?

Oseltamivir phosphate, USP, an influenza neuraminidase inhibitor (NAI), is available as:

In addition to the active ingredient, each capsule contains croscarmellose sodium, povidone K-30, pregelatinized starch (maize), stearic acid, and talc. The 30 mg capsule shell contains gelatin, titanium dioxide, and yellow iron oxide. The 45 mg capsule shell contains black iron oxide, gelatin, and titanium dioxide. The 75 mg capsule shell contains black iron oxide, gelatin, titanium dioxide, and yellow iron oxide. Each capsule is printed with blue ink, which includes FD&C Blue No. 2 indigo carmine aluminum lake as the colorant, methanol, N-butyl alcohol, ethanol, shellac glaze, and titanium dioxide.

Oseltamivir phosphate, USP is a white crystalline solid with the chemical name (3R,4R,5S)-4-acetylamino-5-amino- 3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid, ethyl ester, phosphate (1:1). The chemical formula is C H N O (free base). The molecular weight is 312.4 for oseltamivir free base and 410.4 for oseltamivir phosphate salt. The structural formula is as follows:



What does Oseltamivir Phosphate look like?



What are the available doses of Oseltamivir Phosphate?

Oseltamivir Phosphate Capsules, USP:

What should I talk to my health care provider before I take Oseltamivir Phosphate?

How should I use Oseltamivir Phosphate?

Oseltamivir phosphate capsules are indicated for the treatment of acute, uncomplicated illness due to influenza A and B infection in patients 2 weeks of age and older who have been symptomatic for no more than 48 hours.

Administer oseltamivir phosphate capsules for the treatment of influenza in patients 2 weeks of age or older or for prophylaxis of influenza in patients 1 year and older using:

The capsules may be taken with or without food; however, tolerability may be enhanced if oseltamivir phosphate capsules is taken with food.

Adjust the oseltamivir phosphate capsules dosage in patients with moderate or severe renal impairment .

For patients who cannot swallow capsules, oseltamivir phosphate for oral suspension is the preferred formulation. When oseltamivir phosphate for oral suspension is not available from wholesaler or the manufacturer, oseltamivir phosphate capsules may be opened and mixed with sweetened liquids such as regular or sugar-free chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). During emergency situations when neither the oral suspension nor the age-appropriate strengths of oseltamivir phosphate capsules to mix with sweetened liquids are available, then a pharmacist may prepare an emergency supply of oral suspension from oseltamivir phosphate 75 mg capsules .


What interacts with Oseltamivir Phosphate?

Sorry No Records found


What are the warnings of Oseltamivir Phosphate?

Sorry No Records found


What are the precautions of Oseltamivir Phosphate?

Sorry No Records found


What are the side effects of Oseltamivir Phosphate?

Sorry No records found


What should I look out for while using Oseltamivir Phosphate?

Oseltamivir phosphate capsules are contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme .


What might happen if I take too much Oseltamivir Phosphate?

Reports of overdoses with oseltamivir phosphate have been received from clinical trials and during postmarketing experience. In the majority of cases reporting overdose, no adverse reactions were reported. Adverse reactions reported following overdose were similar in nature to those observed with therapeutic doses of oseltamivir phosphate .


How should I store and handle Oseltamivir Phosphate?

Store at 20º to 25ºC (68º to 77ºF); excursions permitted to 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and yellow ivory opaque body printed “AMNEAL” on cap and “264” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-666-10Oseltamivir phosphate capsules, USP, , are supplied as hard gelatin capsules with yellow ivory opaque cap and light gray opaque body printed “AMNEAL” on cap and “266” on body with blue ink. They are available as follows: Blister pack of 10: NDC 42291-664-10StorageStore the capsules at 20º to 25ºC (68º to 77ºF); excursions permitted between 15º to 30ºC (59º to 86ºF) [see USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Oseltamivir is an antiviral drug with activity against influenza virus .

Non-Clinical Toxicology
Oseltamivir phosphate capsules are contraindicated in patients with known serious hypersensitivity to oseltamivir or any component of the product. Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme .

The sedative effects of metaxalone and other CNS depressants (e.g., alcohol, alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive. Therefore, caution should be exercised with patients who take more than one of these CNS depressants simultaneously.

Cases of anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme have been reported in postmarketing experience with oseltamivir phosphate. Stop oseltamivir phosphate and institute appropriate treatment if an allergic-like reaction occurs or is suspected. The use of oseltamivir phosphate is contraindicated in patients with known serious hypersensitivity to oseltamivir phosphate and .

The following serious adverse reactions are discussed below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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