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Bupivacaine Hydrochloride, Sodium Chloride, Povidone-Iodine, Isopropyl Alcohol
Overview
What is P-Care M?
Sodium Chloride Injection, USP, 0.9% is a sterile, nonpyrogenic solution. The osmolarity is 300 mOsmol per liter (calculated).
Each mL contains: Sodium chloride 9 mg; Water for Injection q.s. It contains no bacteriostat, antimicrobial agent or added buffer and is supplied only in single dose containers. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (pH 4.5-7.0).
Sodium chloride occurs as colorless cubic crystals or white crystalline powder and has a saline taste. Sodium chloride is freely soluble in water. It is soluble in glycerin and slightly soluble in alcohol.
The empirical formula for sodium choride is NaCl and the molecular weight is 58.44.
What does P-Care M look like?
What are the available doses of P-Care M?
Sorry No records found.
What should I talk to my health care provider before I take P-Care M?
Sorry No records found
How should I use P-Care M?
For preparation of the skin prior to injection.
Wipe injection site vigorously and discard
What interacts with P-Care M?
Sorry No Records found
What are the warnings of P-Care M?
Sorry No Records found
What are the precautions of P-Care M?
Sorry No Records found
What are the side effects of P-Care M?
Sorry No records found
What should I look out for while using P-Care M?
MARCAINE is contraindicated in obstetrical paracervical block anesthesia. Its use in this technique has resulted in fetal bradycardia and death.
MARCAINE is contraindicated in patients with a known hypersensitivity to it or to any local anesthetic agent of the amide-type or to other components of MARCAINE solutions.
For External Use Only.
Flammable, keep away from fire or flame.
What might happen if I take too much P-Care M?
When used as a diluent, solvent or intravascular flushing solution, this parenteral preparation is unlikely to pose a threat of sodium chloride or fluid overload except possibly in very small infants. In the event these should occur, reevaluate the patient and institute appropriate corrective measures. (See and ).
How should I store and handle P-Care M?
Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Keep tightly closed (protect from moisture). Protect from light. Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008Sodium Chloride Injection, USP, 0.9%, preservative free, is available as follows:Single dose vials, packaged 25 vials per tray.Preservative Free.Use only if solution is clear and seal intact.Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature].*Vial stoppers do not contain natural rubber latex.45764DRevised: January 2008
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Sodium chloride in water dissociates to provide sodium (Na+) and chloride (Cl—) ions. These ions are normal constituents of the body fluids (principally extracellular) and are essential for maintaining electrolyte balance.
The distribution and excretion of sodium (Na+) and chloride (Cl—)are largely under the control of the kidney which maintains a balance between intake and output.
The small volume of fluid and amount of sodium chloride provided by Sodium Chloride Injection, USP, 0.9%, when used only as a vehicle for parenteral injection of drugs, is unlikely to exert a significant effect on fluid and electrolyte balance except possibly in very small infants.
Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1 to 1.5 liters each for insensible water loss by perspiration and urine production).
Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium.
Non-Clinical Toxicology
MARCAINE is contraindicated in obstetrical paracervical block anesthesia. Its use in this technique has resulted in fetal bradycardia and death.MARCAINE is contraindicated in patients with a known hypersensitivity to it or to any local anesthetic agent of the amide-type or to other components of MARCAINE solutions.
For External Use Only.
Flammable, keep away from fire or flame.
The induction dose requirements of DIPRIVAN Injectable Emulsion may be reduced in patients with intramuscular or intravenous premedication, particularly with narcotics (e.g., morphine, meperidine, and fentanyl, etc.) and combinations of opioids and sedatives (e.g., benzodiazepines, barbiturates, chloral hydrate, droperidol, etc.). These agents may increase the anesthetic or sedative effects of DIPRIVAN Injectable Emulsion and may also result in more pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output.
During maintenance of anesthesia or sedation, the rate of DIPRIVAN Injectable Emulsion administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental analgesic agents (e.g., nitrous oxide or opioids). The concurrent administration of potent inhalational agents (e.g., isoflurane, enflurane, and halothane) during maintenance with DIPRIVAN Injectable Emulsion has not been extensively evaluated. These inhalational agents can also be expected to increase the anesthetic or sedative and cardiorespiratory effects of DIPRIVAN Injectable Emulsion.
DIPRIVAN Injectable Emulsion does not cause a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents (e.g., succinylcholine and nondepolarizing muscle relaxants).
No significant adverse interactions with commonly used premedications or drugs used during anesthesia or sedation (including a range of muscle relaxants, inhalational agents, analgesic agents, and local anesthetic agents) have been observed in adults. In pediatric patients, administration of fentanyl concomitantly with DIPRIVAN Injectable Emulsion may result in serious bradycardia.
General
Pregnancy
Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures and, if possible, retrieve and save the remainder of the unused vehicle for examination.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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