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PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride

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Overview

What is PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

For oral solution: Each 4 liter (4L) PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution jug contains a white powder for reconstitution. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is a combination of polyethylene glycol 3350, an osmotic laxative, and electrolytes (sodium chloride, sodium bicarbonate and potassium chloride) for oral solution.

Each 4 liter jug contains: polyethylene glycol 3350 420 g, sodium bicarbonate 5.72 g, sodium chloride 11.2 g, potassium chloride 1.4 g. The solution is clear and colorless when reconstituted to a final volume of 4 liters with water.

Polyethylene Glycol 3350, NF

Sodium Bicarbonate, USP

The chemical name is NaHCO. The average Molecular Weight is 84.01. The structural formula is:

Sodium Chloride, USP

The chemical name is NaCl. The average Molecular Weight: 58.44. The structural formula is:

Na Cl

Potassium Chloride, USP

The chemical name is KCl. The average Molecular Weight: 74.55. The structural formula is:

K-Cl



What does PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride look like?



What are the available doses of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

For oral solution: polyethylene glycol 3350 420 grams, sodium bicarbonate 5.72 grams, sodium chloride 11.2 grams, potassium chloride 1.48 grams, and flavoring ingredients 2 grams; supplied in one 4 liter disposable jug ()

What should I talk to my health care provider before I take PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

How should I use PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is indicated for bowel cleansing prior to colonoscopy in adults and pediatric patients aged 6 months or greater.

PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution, supplied as a powder, must be reconstituted with water before its use; it is not for direct . The 4 liter reconstituted PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution contains: 420 grams of polyethylene glycol (PEG) 3350, 5.72 grams of sodium bicarbonate, 11.2 grams of sodium chloride, and 1.4 grams of potassium chloride. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution may be used with or without one of the supplied flavor packs.


What interacts with PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

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What are the warnings of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

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What are the precautions of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

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What are the side effects of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

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What should I look out for while using PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is contraindicated in the following conditions:


What might happen if I take too much PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

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How should I store and handle PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride?

Storage:Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. When reconstituted, keep solution refrigerated. Use within 48 hours. Discard unused portion. Keep out of reach of children. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs                   NDC 10572-400-01 Lemon-Lime Flavor PEG-3350, sodium chloride,sodium bicarbonate and potassium chloride for oral solution          NDC 10572-302-01 Storage:Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. When reconstituted, keep solution refrigerated. Use within 48 hours. Discard unused portion. Keep out of reach of children. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs                   NDC 10572-400-01 Lemon-Lime Flavor PEG-3350, sodium chloride,sodium bicarbonate and potassium chloride for oral solution          NDC 10572-302-01 Storage:Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. When reconstituted, keep solution refrigerated. Use within 48 hours. Discard unused portion. Keep out of reach of children. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs                   NDC 10572-400-01 Lemon-Lime Flavor PEG-3350, sodium chloride,sodium bicarbonate and potassium chloride for oral solution          NDC 10572-302-01 Storage:Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. When reconstituted, keep solution refrigerated. Use within 48 hours. Discard unused portion. Keep out of reach of children. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs                   NDC 10572-400-01 Lemon-Lime Flavor PEG-3350, sodium chloride,sodium bicarbonate and potassium chloride for oral solution          NDC 10572-302-01 In powdered form, for oral administration as a solution following reconstitution. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is available in a disposable jug in powdered form containing: PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs:Lemon-Lime Flavor PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution:In powdered form, for oral administration as a solution following reconstitution. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is available in a disposable jug in powdered form containing: PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs:Lemon-Lime Flavor PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution:In powdered form, for oral administration as a solution following reconstitution. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is available in a disposable jug in powdered form containing: PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs:Lemon-Lime Flavor PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution:In powdered form, for oral administration as a solution following reconstitution. PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is available in a disposable jug in powdered form containing: PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution with Flavor Packs:Lemon-Lime Flavor PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution:


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The primary mode of action is thought to be through the osmotic effect of polyethylene glycol 3350 which causes water to be retained in the colon and produces a watery stool.

Non-Clinical Toxicology
PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution is contraindicated in the following conditions:

Because of its antianabolic activity, concurrent administration of tetracycline may reduce the potential effects of amino acids infused with dextrose as part of a parenteral feeding regimen.

see Drug Interactions

The following adverse reactions have been identified during post-approval use of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Nausea, abdominal fullness and bloating are the most common adverse reactions (occurred in up to 50% of patients) to administration of PEG-3350, sodium chloride, sodium bicarbonate and potassium chloride for oral solution. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and usually subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis and (rarely) anaphylactic reaction have been reported which may represent allergic reactions.

Published literature contains isolated reports of serious adverse reactions following the administration of PEG-electrolyte solution products in patients over 60 years of age. These adverse events include upper GI bleeding from Mallory-Weiss Tear, esophageal perforation, asystole, sudden dyspnea with pulmonary edema, and “butterfly-like” infiltrates on chest X-ray after vomiting and aspirating PEG.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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