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penciclovir
Overview
What is Penciclovir?
Penciclovir Cream, 1% contains penciclovir, an antiviral agent active against herpes viruses. Penciclovir Cream is available for topical administration as a 1% white cream. Each gram of Penciclovir Cream contains 10 mg of penciclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, polyoxyl 20 cetostearyl ether, propylene glycol, purified water and white petrolatum.
Chemically, penciclovir is known as 9-[4-hydroxy-3(hydroxymethyl)butyl] guanine. Its molecular formula is CHNO; its molecular weight is 253.26. It is a synthetic acyclic guanine derivative and has the following structure:
Figure 1: Structural Formula of Penciclovir
Penciclovir is a white to pale yellow solid. At 20°C it has a solubility of 0.2 mg/mL in methanol, 1.3 mg/ mL in propylene glycol, and 1.7 mg/mL in water. In aqueous buffer (pH 2) the solubility is 10.0 mg/mL. Penciclovir is not hygroscopic. Its partition coefficient in n-octanol/water at pH 7.5 is 0.024 (logP = -1.62).
What does Penciclovir look like?
What are the available doses of Penciclovir?
Each gram of Penciclovir Cream contains 10 mg of penciclovir in a cream base, which is equivalent to 1% (w/w).
What should I talk to my health care provider before I take Penciclovir?
How should I use Penciclovir?
Penciclovir Cream is a nucleoside analog HSV DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in adults and children 12 years of age or older.
Penciclovir Cream should be applied every 2 hours during waking hours for a period of 4 days. Treatment should be started as early as possible (i.e., during the prodrome or when lesions appear).
What interacts with Penciclovir?
Sorry No Records found
What are the warnings of Penciclovir?
Sorry No Records found
What are the precautions of Penciclovir?
Sorry No Records found
What are the side effects of Penciclovir?
Sorry No records found
What should I look out for while using Penciclovir?
Penciclovir Cream is contraindicated in patients with known hypersensitivity to the product or any of its components.
What might happen if I take too much Penciclovir?
Since penciclovir is poorly absorbed following oral administration, adverse reactions related to penciclovir ingestion are unlikely. There is no information on overdose.
How should I store and handle Penciclovir?
Store at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature].Dispense in tight container as defined in the USP, with a child-resistant closure (as required).Store at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature].Dispense in tight container as defined in the USP, with a child-resistant closure (as required).Penciclovir Cream, 1% is supplied in a 5 gram tube containing 10 mg of penciclovir per gram.NDC 40085-415-05Store at 20ºC to 25ºC (68ºF to 77ºF); excursions permitted to 15ºC to 30ºC (59ºF to 86ºF) [see USP Controlled Room Temperature].Penciclovir Cream, 1% is supplied in a 5 gram tube containing 10 mg of penciclovir per gram.NDC 40085-415-05Store at 20ºC to 25ºC (68ºF to 77ºF); excursions permitted to 15ºC to 30ºC (59ºF to 86ºF) [see USP Controlled Room Temperature].Penciclovir Cream, 1% is supplied in a 5 gram tube containing 10 mg of penciclovir per gram.NDC 40085-415-05Store at 20ºC to 25ºC (68ºF to 77ºF); excursions permitted to 15ºC to 30ºC (59ºF to 86ºF) [see USP Controlled Room Temperature].
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Penciclovir is an antiviral agent active against herpes viruses [see ].
Non-Clinical Toxicology
Penciclovir Cream is contraindicated in patients with known hypersensitivity to the product or any of its components.No untoward clinical manifestations have been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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