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Permethrin
Overview
What is Permethrin?
Permethrin Cream 5% is a topical scabicidal agent for the treatment of infestation with (scabies). It is available in a white to off-white, vanishing cream base.
Permethrin cream is for topical use only.
Structural Formula:
Chemical Name:
.
Each gram contains permethrin 50 mg (5%) and the inactive ingredients butylated hydroxytoluene, carbomer 934P, coconut oil, glycerin, glyceryl stearate, isopropyl myristate, lanolin alcohols, light mineral oil, polyoxyethylene cetyl ethers, purified water, and sodium hydroxide. Formaldehyde 1 mg (01%) is added as a preservative.
What does Permethrin look like?
What are the available doses of Permethrin?
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What should I talk to my health care provider before I take Permethrin?
Sorry No records found
How should I use Permethrin?
Permethrin cream is indicated for the treatment of infestation with (scabies).
Adults and children: Thoroughly massage permethrin cream into the skin from the head to the soles of the feet. Scabies rarely infests the scalp of adults, although the hairline, neck, temple, and forehead may be infested in infants and geriatric patients. Usually 30 grams is sufficient for an average adult. The cream should be removed by washing (shower or bath) after 8 to 14 hours. Infants should be treated on the scalp, temple and forehead. ONE APPLICATION IS GENERALLY CURATIVE.
Patients may experience persistent pruritus after treatment. This is rarely a sign of treatment failure and is not an indication for retreatment. Demonstrable living mites after 14 days indicate that retreatment is necessary.
What interacts with Permethrin?
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What are the warnings of Permethrin?
Sorry No Records found
What are the precautions of Permethrin?
Sorry No Records found
What are the side effects of Permethrin?
Sorry No records found
What should I look out for while using Permethrin?
Permethrin cream is contraindicated in patients with known hypersensitivity to any of its components, to any synthetic pyrethroid or pyrethrin.
If hypersensitivity to permethrin cream occurs, discontinue use.
What might happen if I take too much Permethrin?
No instance of accidental ingestion of permethrin cream has been reported. If ingested, gastric lavage and general supportive measures should be employed.
How should I store and handle Permethrin?
Product: 76413-159NDC: 76413-159-60 60 g in a TUBE Product: 76413-159NDC: 76413-159-60 60 g in a TUBE
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
Permethrin is rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine. Although the amount of permethrin absorbed after a single application of the 5% cream has not been determined precisely, data from studies with C-labeled permethrin and absorption studies of the cream applied to patients with moderate to severe scabies indicate it is 2% or less of the amount applied.
Non-Clinical Toxicology
Permethrin cream is contraindicated in patients with known hypersensitivity to any of its components, to any synthetic pyrethroid or pyrethrin.If hypersensitivity to permethrin cream occurs, discontinue use.
Neprilysin Inhibitors
Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema (see WARNINGS).
Scabies infestation is often accompanied by pruritis, edema and erythema. Treatment with permethrin cream may temporarily exacerbate these conditions.
In clinical trials, generally mild and transient burning and stinging followed application with permethrin cream in 10% of patients and was associated with the severity of infestation. Pruritis was reported in 7% of patients at various times post-application. Erythema, numbness, tingling, and rash were reported in 1 to 2% or less of patients (see : ).
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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