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Picato

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Overview

What is Picato?

Picato (ingenol mebutate) gel, 0.015% or 0.05% is a clear colorless gel for topical administration, which contains the active substance ingenol mebutate, an inducer of cell death.

The chemical name of ingenol mebutate is:

2-Butenoic acid, 2-methyl-, (1a,2,5,5a,6,8a,9,10a)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1-2,8a-methanocyclopenta []cyclopropa[]cyclodecen-6-yl ester, (2Z) -

or

(1a,2,5,5a,6,8a,9,10a)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-12,8a-methanocyclopenta[]cyclopropa[]cyclodecen-6-yl (2Z) 2 methylbut-2-enoate.

The molecular formula is CHO and molecular weight is 430.5. Ingenol mebutate is represented by the following structural formula:

Ingenol mebutate is a white to pale yellow crystalline powder.

Picato gel, 0.015% and 0.05% contains 150 mcg and 500 mcg of ingenol mebutate, respectively in each gram of gel consisting of isopropyl alcohol, hydroxyethyl cellulose, citric acid monohydrate, sodium citrate, benzyl alcohol and purified water.

Picato gel is a clear colorless gel and supplied in unit dose laminate tubes, for single use, containing a nominal fill weight of 0.47 g, with a deliverable weight of 0.25 g. The tubes should be discarded after single use.



What does Picato look like?



What are the available doses of Picato?

Gel containing ingenol mebutate 0.015% or 0.05% ()

What should I talk to my health care provider before I take Picato?

How should I use Picato?

Picato gel is indicated for the topical treatment of actinic keratosis.

For topical use only; Picato gel is not for oral, ophthalmic, or intravaginal use.

Avoid transfer of Picato gel to periocular area .

Avoid application near and around the mouth and lips.

For the treatment of actinic keratosis o Picato gel, should be applied to the affected area once daily for .

For the treatment of actinic keratosis Picato gel, should be applied to the affected area once daily for .


What interacts with Picato?

Sorry No Records found


What are the warnings of Picato?

Sorry No Records found


What are the precautions of Picato?

Sorry No Records found


What are the side effects of Picato?

Sorry No records found


What should I look out for while using Picato?

Picato gel is contraindicated in patients with known hypersensitivity to ingenol mebutate or any component of the formulation. Anaphylaxis, as well as allergic reactions leading to hospitalization have been reported in postmarketing use with Picato gel .


What might happen if I take too much Picato?

Topical overdosing of Picato gel could result in an increased incidence of local skin reactions.


How should I store and handle Picato?

StorageStore in a well-closed container at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) [see USP Controlled Room Temperature].StorageStore in a well-closed container at 20° - 25°C (68° - 77°F); excursions permitted to 15° - 30°C (59° - 86°F) [see USP Controlled Room Temperature].Picato gel is a clear colorless gel and is supplied in unit dose laminate tubes containing a nominal fill weight of 0.47 g, with a deliverable weight of 0.25 g. The tubes should be discarded after single use.Picato gel is available in 2 dosage strengths: 0.015% and 0.05%. Store Picato gel in a refrigerator at 36ºF – 46ºF (2ºC – 8ºC); excursions permitted between 32ºF – 59ºF (0ºC – 15ºC) (see USP for controlled cold temperature). Protect from freezing. Picato gel is a clear colorless gel and is supplied in unit dose laminate tubes containing a nominal fill weight of 0.47 g, with a deliverable weight of 0.25 g. The tubes should be discarded after single use.Picato gel is available in 2 dosage strengths: 0.015% and 0.05%. Store Picato gel in a refrigerator at 36ºF – 46ºF (2ºC – 8ºC); excursions permitted between 32ºF – 59ºF (0ºC – 15ºC) (see USP for controlled cold temperature). Protect from freezing. Picato gel is a clear colorless gel and is supplied in unit dose laminate tubes containing a nominal fill weight of 0.47 g, with a deliverable weight of 0.25 g. The tubes should be discarded after single use.Picato gel is available in 2 dosage strengths: 0.015% and 0.05%. Store Picato gel in a refrigerator at 36ºF – 46ºF (2ºC – 8ºC); excursions permitted between 32ºF – 59ºF (0ºC – 15ºC) (see USP for controlled cold temperature). Protect from freezing.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The mechanism of action by which Picatogel induces cell death in treating AK lesions is unknown.

Non-Clinical Toxicology
Picato gel is contraindicated in patients with known hypersensitivity to ingenol mebutate or any component of the formulation. Anaphylaxis, as well as allergic reactions leading to hospitalization have been reported in postmarketing use with Picato gel .

Avoid treatment in the periocular area. Eye disorders, including severe eye pain, chemical conjunctivitis, corneal burn, eyelid edema, eyelid ptosis, periorbital edema can occur after exposure .

To avoid transfer of the drug into the eyes and to the periocular area during and after application, patients should wash hands well after applying Picato gel. If accidental exposure occurs, the area should be flushed with water and the patient should seek medical care as soon as possible.

The following serious adverse reactions are discussed in more detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

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Tips

Tips

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Interactions

Interactions

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