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Pioglitazone HCL and Metformin HCL

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Overview

What is Pioglitazone HCL and Metformin HCL?

Pioglitazone and metformin hydrochloride tablets, USP are a thiazolidinediones and biguanide combination product that contains two oral antidiabetic medications: pioglitazone hydrochloride and metformin hydrochloride.

Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl) ethoxy]phenyl]methyl]-2,4-] thiazolidinedione monohydrochloride contains one asymmetric carbon, and the compound is synthesized and used as the racemic mixture. The two enantiomers of pioglitazone interconvert . No differences were found in the pharmacologic activity between the two enantiomers. The structural formula is as shown:

Pioglitazone hydrochloride, USP is an odorless white crystalline powder that has a molecular formula of CHNOS•HCl and a molecular weight of 392.90 daltons. It is soluble in -dimethylformamide, slightly soluble in anhydrous ethanol, very slightly soluble in acetone and acetonitrile, practically insoluble in water, and insoluble in ether.

Metformin hydrochloride (-dimethylimidodicarbonimidic diamide hydrochloride), USP is a white crystalline powder with a molecular formula of CHN•HCl and a molecular weight of 165.62. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown:

Pioglitazone and metformin hydrochloride are available as a tablet for oral administration containing 15 mg pioglitazone (as the base) with 500 mg metformin hydrochloride (15 mg/500 mg) or 15 mg pioglitazone (as the base) with 850 mg metformin hydrochloride (15 mg/850 mg) formulated with the following excipients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, and titanium dioxide.



What does Pioglitazone HCL and Metformin HCL look like?



What are the available doses of Pioglitazone HCL and Metformin HCL?

Tablets: 15 mg pioglitazone/500 mg metformin hydrochloride and 15 mg pioglitazone/850 mg metformin hydrochloride (3)

What should I talk to my health care provider before I take Pioglitazone HCL and Metformin HCL?

How should I use Pioglitazone HCL and Metformin HCL?

Pioglitazone and metformin hydrochloride tablets are a thiazolidinedione and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both pioglitazone and metformin is appropriate. (1, 14)

Important Limitations of Use:

Pioglitazone and metformin hydrochloride tablets should be taken with meals to reduce the gastrointestinal side effects associated with metformin.

If therapy with a combination tablet containing pioglitazone and metformin is considered appropriate the recommended starting dose is:


What interacts with Pioglitazone HCL and Metformin HCL?

Sorry No Records found


What are the warnings of Pioglitazone HCL and Metformin HCL?

Sorry No Records found


What are the precautions of Pioglitazone HCL and Metformin HCL?

Sorry No Records found


What are the side effects of Pioglitazone HCL and Metformin HCL?

Sorry No records found


What should I look out for while using Pioglitazone HCL and Metformin HCL?

Initiation in patients with established New York Heart Association   (NYHA) Class III or IV heart failure . (4)

Severe renal impairment: (eGFR below 30 mL/min/1.73 m(4)

Use in patients with known hypersensitivity to pioglitazone, metformin or any other component of pioglitazone and metformin hydrochloride tablets. (4)

Metabolic acidosis, including diabetic ketoacidosis. (4, 5.2)


What might happen if I take too much Pioglitazone HCL and Metformin HCL?

Pioglitazone

During controlled clinical trials, one case of overdose with pioglitazone was reported.  A male patient took 120 mg per day for four days, then 180 mg per day for seven days. The patient denied any clinical symptoms during this period.

In the event of overdosage, appropriate supportive treatment should be initiated according to the patient's clinical signs and symptoms.

Metformin hydrochloride

Overdose of metformin hydrochloride has occurred, including ingestion of amounts greater than 50 grams. Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin hydrochloride has been established. Lactic acidosis has been reported in approximately 32% of metformin overdose cases . Metformin is dialyzable with a clearance of up to 170 mL/min under good hemodynamic conditions. Therefore, hemodialysis may be useful for removal of accumulated metformin from patients in whom metformin overdosage is suspected.


How should I store and handle Pioglitazone HCL and Metformin HCL?

Storage and HandlingStore at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]. KEEP TIGHTLY CLOSED. Capecitabine tablets, USP are cytotoxic drug. Follow applicable special handling and disposal procedures. Any unused product should be disposed of in accordance with local requirements, or drug take back programs. Storage and HandlingStore at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]. KEEP TIGHTLY CLOSED. Capecitabine tablets, USP are cytotoxic drug. Follow applicable special handling and disposal procedures. Any unused product should be disposed of in accordance with local requirements, or drug take back programs. Storage and HandlingStore at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). [See USP Controlled Room Temperature]. KEEP TIGHTLY CLOSED. Capecitabine tablets, USP are cytotoxic drug. Follow applicable special handling and disposal procedures. Any unused product should be disposed of in accordance with local requirements, or drug take back programs. Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage: Pioglitazone and metformin hydrochloride tablets, USP are available in 15 mg pioglitazone (as the base)/500 mg metformin hydrochloride and 15 mg pioglitazone (as the base)/850 mg metformin hydrochloride tablets as follows:       15 mg/500 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/500" on one side and "1280" on other side, available in:Bottles of 60                           NDC 13668-280-60Bottles of 180                         NDC 13668-280-33Bottles of 500                         NDC 13668-280-05Bottles of 1000                       NDC 13668-280-10100 Unit dose Tablets             NDC 13668-280-74      15 mg/850 mg tablet: white to off-white colored, capsule shaped, biconvex, film coated tablets debossed with "15/850" on one side and "1281" on other side, available in:Bottles of 60                           NDC 13668-281-60Bottles of 180                         NDC 13668-281-33Bottles of 500                         NDC 13668-281-05Bottles of 750                         NDC 13668-281-49100 Unit dose Tablets             NDC 13668-281-74Storage:


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Pioglitazone and metformin hydrochloride tablets combine two antidiabetic medications with different mechanisms of action to improve glycemic control in adults with type 2 diabetes: pioglitazone, a thiazolidinedione, and metformin hydrochloride, a biguanide. Thiazolidinediones are insulin-sensitizing agents that act primarily by enhancing peripheral glucose utilization, whereas biguanides act primarily by decreasing endogenous hepatic glucose production.

Pioglitazone

Pioglitazone is a thiazolidinedione that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone is not an insulin secretagogue. Pioglitazone is an agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.

In animal models of diabetes, pioglitazone reduces the hyperglycemia, hyperinsulinemia, and hypertriglyceridemia characteristic of insulin-resistant states such as type 2 diabetes. The metabolic changes produced by pioglitazone result in increased responsiveness of insulin-dependent tissues and are observed in numerous animal models of insulin resistance.

Because pioglitazone enhances the effects of circulating insulin (by decreasing insulin resistance), it does not lower blood glucose in animal models that lack endogenous insulin.

Metformin hydrochloride

Metformin hydrochloride improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Metformin does not produce hypoglycemia in either patients with type 2 diabetes or healthy subjects [except in specific circumstances, ] and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may actually decrease.

Non-Clinical Toxicology
Initiation in patients with established New York Heart Association   (NYHA) Class III or IV heart failure . (4)

Severe renal impairment: (eGFR below 30 mL/min/1.73 m(4)

Use in patients with known hypersensitivity to pioglitazone, metformin or any other component of pioglitazone and metformin hydrochloride tablets. (4)

Metabolic acidosis, including diabetic ketoacidosis. (4, 5.2)

Certain other antibiotics (aminoglycosides and polymyxin) have also been reported to interfere with the nerve transmission at the neuromuscular junction. Based on this reported activity, they should not be given concomitantly with colistimethate for injection except with the greatest caution.

Curariform muscle relaxants (e.g., tubocurarine) and other drugs, including ether, succinylcholine, gallamine, decamethonium and sodium citrate, potentiate the neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate for injection.

Sodium cephalothin may enhance the nephrotoxicity of colistimethate for injection. The concomitant use of sodium cephalothin and colistimethate for injection should be avoided.

Pioglitazone

Pioglitazone, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when pioglitazone is used in combination with insulin.  Fluid retention may lead to or exacerbate congestive heart failure. Patients treated with pioglitazone and metformin hydrochloride should be observed for signs and symptoms of congestive heart failure. If congestive heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of pioglitazone and metformin hydrochloride must be considered , .

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).