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Polyethylene Glycol 3350

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Overview

What is Polyethylene Glycol 3350?

A white powder for reconstitution. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder For Oral Solution) is a synthetic polyglycol having an average molecular weight of 3350. The actual molecular weight is not less than 90.0 percent and not greater than 110.0 percent of the nominal value. The chemical formula is HO(CHO)H in which n represents the average number of oxyethylene groups. Below 55°C it is a free flowing white powder freely soluble in water. Polyethylene Glycol 3350 NF is an osmotic agent for the treatment of constipation.



What does Polyethylene Glycol 3350 look like?



What are the available doses of Polyethylene Glycol 3350?

Sorry No records found.

What should I talk to my health care provider before I take Polyethylene Glycol 3350?

Sorry No records found

How should I use Polyethylene Glycol 3350?

For the treatment of occasional constipation. This product should be used for 2 weeks or less or as directed by a physician.

The usual dose is 17 grams (about 1 heaping tablespoon) of powder per day (or as directed by physician) in 4 to 8 ounces of water, juice, soda, coffee, or tea. Each bottle of Polyethylene Glycol 3350 NF is supplied with a dosing cup marked to contain 17 grams of laxative powder when filled to the indicated line. Two to 4 days (48 to 96 hours) may be required to produce a bowel movement.


What interacts with Polyethylene Glycol 3350?

Polyethylene Glycol 3350 NF is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to polyethylene glycol.



What are the warnings of Polyethylene Glycol 3350?

Cyclobenzaprine HCl may enhance the effects of alcohol, barbiturates, and other CNS depressants.


What are the precautions of Polyethylene Glycol 3350?

General

Patients presenting with complaints of constipation should have a thorough medical history and physical examination to detect associated metabolic, endocrine and neurogenic conditions and medications. A diagnostic evaluation should include a structural examination of the colon. Patients should be educated about good defecatory and eating habits (such as high fiber diets) and lifestyle changes (adequate dietary fiber and fluid intake, regular exercise) which may produce more regular bowel habits.

Polyethylene Glycol 3350 NF should be administered after being dissolved in approximately 4 to 8 ounces of water, juice, soda, coffee or tea.

Information for Patients

Polyethylene Glycol 3350 NF softens the stool and increases the frequency of bowel movements by retaining water in the stool. It should always be taken by mouth after being dissolved in 4 to 8 ounces of water, juice, soda, coffee, or tea. Should unusual cramps, bloating, or diarrhea occur, consult your physician.

Two to 4 days may be required to produce a bowel movement. This product should be used for 2 weeks or less or as directed by your physician. Prolonged, frequent or excessive use of Polyethylene Glycol 3350 NF may result in electrolyte imbalance and dependence on laxatives.

Laboratory Tests

No clinically significant effects on laboratory tests have been demonstrated.

Drug Interactions

No specific drug interactions have been demonstrated.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long term carcinogenicity studies, genetic toxicity studies or reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350 NF.

Pregnancy

Animal reproductive studies have not been performed with Polyethylene Glycol 3350 NF.

It is also not known whether Polyethylene Glycol 3350 NF can cause fetal harm when administered to a pregnant woman, or can affect reproductive capacity. Polyethylene Glycol 3350 NF should only be administered to a pregnant woman if clearly needed.

Pediatric Use

Safety and effectiveness in pediatric patients has not been established.

Geriatric Use

There is no evidence for special considerations when Polyethylene Glycol 3350 NF is administered to elderly patients. In geriatric nursing home patients a higher incidence of diarrhea occurred at the recommended 17 g dose. If diarrhea occurs Polyethylene Glycol 3350 NF should be discontinued.


What are the side effects of Polyethylene Glycol 3350?

Nausea, abdominal bloating, cramping and flatulence may occur. High doses may produce diarrhea and excessive stool frequency, particularly in elderly nursing home patients. Patients taking other medications containing polyethylene glycol have occasionally developed urticaria suggestive of an allergic reaction.


What should I look out for while using Polyethylene Glycol 3350?

Polyethylene Glycol 3350 NF is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to polyethylene glycol.

Patients with symptoms suggestive of bowel obstruction (nausea, vomiting, abdominal pain or distention) should be evaluated to rule out this condition before initiating Polyethylene Glycol 3350 NF therapy.


What might happen if I take too much Polyethylene Glycol 3350?

There have been no reports of accidental overdosage. In the event of overdosage, diarrhea would be the expected major event. If an overdose of drug occurred without concomitant ingestion of fluid, dehydration due to diarrhea may result. Medication should be terminated and free water administered. The oral LD is > 50 gm/kg in mice, rats and rabbits.


How should I store and handle Polyethylene Glycol 3350?

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder for Oral Solution) is available in 255 grams of laxative powder NDC 71205-011-25 Polyethylene Glycol 3350 NF 255gThe dosing cup supplied with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350 NF dose of 17 grams (about 1 heaping tablespoonful).Rx onlyKeep this and all medications out of the reach of children.In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder for Oral Solution) is available in 255 grams of laxative powder NDC 71205-011-25 Polyethylene Glycol 3350 NF 255gThe dosing cup supplied with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350 NF dose of 17 grams (about 1 heaping tablespoonful).Rx onlyKeep this and all medications out of the reach of children.In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder for Oral Solution) is available in 255 grams of laxative powder NDC 71205-011-25 Polyethylene Glycol 3350 NF 255gThe dosing cup supplied with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350 NF dose of 17 grams (about 1 heaping tablespoonful).Rx onlyKeep this and all medications out of the reach of children.In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder for Oral Solution) is available in 255 grams of laxative powder NDC 71205-011-25 Polyethylene Glycol 3350 NF 255gThe dosing cup supplied with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350 NF dose of 17 grams (about 1 heaping tablespoonful).Rx onlyKeep this and all medications out of the reach of children.In powdered form, for oral administration after dissolution in water, juice, soda, coffee, or tea. Polyethylene Glycol 3350 NF (Polyethylene Glycol 3350 Powder for Oral Solution) is available in 255 grams of laxative powder NDC 71205-011-25 Polyethylene Glycol 3350 NF 255gThe dosing cup supplied with each bottle is marked with a measuring line and may be used to measure a single Polyethylene Glycol 3350 NF dose of 17 grams (about 1 heaping tablespoonful).Rx onlyKeep this and all medications out of the reach of children.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Non-Clinical Toxicology
Polyethylene Glycol 3350 NF is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to polyethylene glycol.

Patients with symptoms suggestive of bowel obstruction (nausea, vomiting, abdominal pain or distention) should be evaluated to rule out this condition before initiating Polyethylene Glycol 3350 NF therapy.

No specific drug interactions have been demonstrated.

Patients presenting with complaints of constipation should have a thorough medical history and physical examination to detect associated metabolic, endocrine and neurogenic conditions and medications. A diagnostic evaluation should include a structural examination of the colon. Patients should be educated about good defecatory and eating habits (such as high fiber diets) and lifestyle changes (adequate dietary fiber and fluid intake, regular exercise) which may produce more regular bowel habits.

Polyethylene Glycol 3350 NF should be administered after being dissolved in approximately 4 to 8 ounces of water, juice, soda, coffee or tea.

Nausea, abdominal bloating, cramping and flatulence may occur. High doses may produce diarrhea and excessive stool frequency, particularly in elderly nursing home patients. Patients taking other medications containing polyethylene glycol have occasionally developed urticaria suggestive of an allergic reaction.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

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Tips

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Interactions

Interactions

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