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polymyxin B sulfate, trimethoprim sulfate

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Overview

What is POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is a sterile antimicrobial solution for topical ophthalmic use.



What does POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE look like?



What are the available doses of POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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What should I talk to my health care provider before I take POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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How should I use POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms:

*Efficacy for this organism in this organ system was studied in fewer than 10 infections.

In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.


What interacts with POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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What are the warnings of POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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What are the precautions of POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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What are the side effects of POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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What should I look out for while using POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is contraindicated in patients with known hypersensivitity to any of its components.

NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to polymyxin B sulfate and trimethoprim ophthalmic solution, USP occurs discontinue use. Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.


What might happen if I take too much POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

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How should I store and handle POLYMYXIN B SULFATE and TRIMETHOPRIM SULFATE?

Store VPRIV at 2 °C to 8°C (36°F to 46°F). Do not use VPRIV after the expiration date on the vial. Do not freeze.Protect vial from light.Store VPRIV at 2 °C to 8°C (36°F to 46°F). Do not use VPRIV after the expiration date on the vial. Do not freeze.Protect vial from light.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows: 10 mL in 10 mL bottle - NDC 68788-9820-1Storage:Revised: 11/2013© 2013 Allergan, Inc.Irvine, CA 92612, U.S.A.® mark owned by Allergan, Inc.Made in the U.S.A. 71756PY11 Relabeled By: Preferred Pharmaceuticals Inc.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme, and therefore, selectively interferes with bacterial biosynthesis of nucleic acids and proteins.

Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially . It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.

Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03 mcg/mL trimethoprim and 1 unit/mL polymyxin B.

Non-Clinical Toxicology
Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is contraindicated in patients with known hypersensivitity to any of its components.

NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to polymyxin B sulfate and trimethoprim ophthalmic solution, USP occurs discontinue use. Polymyxin B sulfate and trimethoprim ophthalmic solution, USP is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.

As with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.

The most frequent adverse reaction to polymyxin B sulfate and trimethoprim ophthalmic solution, USP is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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