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Polytrim
Overview
What is Polytrim?
POLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is a sterile antimicrobial solution for topical ophthalmic use. It has pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg.
What does Polytrim look like?
What are the available doses of Polytrim?
Sorry No records found.
What should I talk to my health care provider before I take Polytrim?
Sorry No records found
How should I use Polytrim?
POLYTRIM Ophthalmic Solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: ,
In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.
What interacts with Polytrim?
POLYTRIM Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components.
What are the warnings of Polytrim?
Sorry No Records found
What are the precautions of Polytrim?
General:
As with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.
Information for Patients:
Avoid contaminating the applicator tip with material from the eye, fingers, or other source. This precaution is necessary if the sterility of the drops is to be maintained.
If redness, irritation, swelling or pain persists or increases, discontinue use immediately and contact your physician. Patients should be advised not to wear contact lenses if they have signs and symptoms of ocular bacterial infections.
Carcinogenesis, Mutagenesis, Impairment of Fertility:
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No adverse effects on fertility or general reproductive performance were observed in rats given trimethoprim in oral dosages as high as 70 mg/kg/day for males and 14 mg/kg/day for females.
Pregnancy:
Teratogenic Effects
Trimethoprim has been shown to be teratogenic in the rat when given in oral doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with oral doses 6 times the human therapeutic dose.
While there are no large well-controlled studies on the use of trimethoprim in pregnant women, Brumfitt and Pursell, in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or oral trimethoprim in combination with sulfamethoxazole. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter.
Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Nursing Mothers:
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when POLYTRIM Ophthalmic Solution is administered to a nursing woman.
Pediatric Use:
Safety and effectiveness in children below the age of 2 months have not been established (see ).
Geriatric Use:
No overall differences in safety or effectiveness have been observed between elderly and other adult patients.
What are the side effects of Polytrim?
The most frequent adverse reaction to POLYTRIM Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.
What should I look out for while using Polytrim?
POLYTRIM Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components.
NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to POLYTRIM occurs, discontinue use. POLYTRIM Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.
What might happen if I take too much Polytrim?
Sorry No Records found
How should I store and handle Polytrim?
Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Protect from light.DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Protect from light.DISPENSE IN TIGHT, LIGHT-RESISTANT CONTAINER.POLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10PPOLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:10 mL in 10 mL bottle - NDC 0023-7824-10NoteRx onlyRevised August 2004© 2004 Allergan, Inc.8317X 71756US10P
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Microbiology:
In vitro
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Non-Clinical Toxicology
POLYTRIM Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components.NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to POLYTRIM occurs, discontinue use. POLYTRIM Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.
See .
As with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.
The most frequent adverse reaction to POLYTRIM Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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