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Mupirocin 2%, Dimethicone 5%, Chlorhexidine Gluconate 4%
Overview
What is Pre and Post Sx Pouch?
Each gram of Mupirocin Ointment USP, 2% contains 20 mg mupirocin in a bland water miscible ointment base (polyethylene glycol ointment, NF) consisting of polyethylene glycol 400 and polyethylene glycol 3350. Mupirocin is a naturally occurring antibiotic. The chemical name is (
)-(2
,3
,4
,5
)-5-[(2
,3
,4
,5
)-2,3-Epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-β-methyl-2
-pyran-2-crotonic acid, ester with 9-hydroxynonanoic acid. The molecular formula of mupirocin is C
H
O
and the molecular weight is 500.62.
The chemical structure is:
What does Pre and Post Sx Pouch look like?
What are the available doses of Pre and Post Sx Pouch?
Sorry No records found.
What should I talk to my health care provider before I take Pre and Post Sx Pouch?
Sorry No records found
How should I use Pre and Post Sx Pouch?
Mupirocin Ointment USP, 2% is indicated for the topical treatment of impetigo due to:
and
.
A small amount of Mupirocin Ointment USP, 2% should be applied to the affected area 3 times daily. The area treated may be covered with a gauze dressing if desired. Patients not showing a clinical response within 3 to 5 days should be re-evaluated.
What interacts with Pre and Post Sx Pouch?
This drug is contraindicated in patients with known hypersensitivity to any of the constituents of the product.
What are the warnings of Pre and Post Sx Pouch?
Avoid contact with the eyes. In case of accidental contact, rinse well with water.
In the event of sensitization or severe local irritation from Mupirocin Ointment USP, 2%, usage should be discontinued.
If CDAD is suspected or confirmed, ongoing antibacterial drug use not directed against
may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of
, and surgical evaluation should be instituted as clinically indicated.
What are the precautions of Pre and Post Sx Pouch?
As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.
Mupirocin Ointment USP, 2% is not formulated for use on mucosal surfaces. Intranasal use has been associated with isolated reports of stinging and drying.
A paraffin-based formulation - *Bactroban Nasal® (mupirocin calcium ointment ) - is available for intranasal use.
Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. In common with other polyethylene glycol-based ointments, Mupirocin Ointment USP, 2% should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment.
Mupirocin Ointment USP, 2% should not be used with intravenous cannulae or at central intravenous sites because of the potential to promote fungal infections and antimicrobial resistance.
Information for Patients -
Use this medication only as directed by the healthcare provider. It is for external use only. Avoid contact with the eyes. If Mupirocin Ointment USP, 2% gets in or near the eyes, rinse thoroughly with water. The medication should be stopped and the healthcare provider contacted if irritation, severe itching, or rash occurs. If impetigo has not improved in 3 to 5 days, contact the healthcare provider.
The effect of the concurrent application of Mupirocin Ointment USP, 2% and other drug products has not been studied.
Carcinogenesis, Mutagenesis, Impairment of Fertility -
Long-term studies in animals to evaluate carcinogenic potential of mupirocin have not been conducted.
Results of the following studies performed with mupirocin calcium or mupirocin sodium
and
did not indicate a potential for genotoxicity: Rat primary hepatocyte unscheduled DNA synthesis, sediment analysis for DNA strand breaks,
reversion test (Ames),
mutation assay, metaphase analysis of human lymphocytes, mouse lymphoma assay, and bone marrow micronuclei assay in mice.
Reproduction studies were performed in male and female rats with mupirocin administered subcutaneously at doses up to 14 times a human topical dose (approximately 60 mg mupirocin per day) on a mg/m
basis and revealed no evidence of impaired fertility and reproductive performance from mupirocin.
Pregnancy:
Nursing Mothers -
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Mupirocin Ointment USP, 2% is administered to a nursing woman.
Pediatric Use -
The safety and effectiveness of Mupirocin Ointment USP, 2% have been established in the age range of 2 months to 16 years. Use of mupirocin ointment USP, 2% in these age groups is supported by evidence from adequate and well-controlled trials of mupirocin ointment USP, 2% in impetigo in pediatric subjects studied as part of the pivotal clinical trials (see
).
What are the side effects of Pre and Post Sx Pouch?
The following local adverse reactions have been reported in connection with the use of mupirocin ointment USP, 2%: burning, stinging, or pain in 1.5% of subjects; itching in 1% of subjects; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of subjects. Systemic allergic reactions, including anaphylaxis, urticaria, angioedema and generalized rash have been reported in patients treated with mupirocin formulations.
What should I look out for while using Pre and Post Sx Pouch?
This drug is contraindicated in patients with known hypersensitivity to any of the constituents of the product.
Avoid contact with the eyes. In case of accidental contact, rinse well with water.
In the event of sensitization or severe local irritation from Mupirocin Ointment USP, 2%, usage should be discontinued.
Clostridium difficile
C. difficile
C. difficile
C. difficile
If CDAD is suspected or confirmed, ongoing antibacterial drug use not directed against
may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of
, and surgical evaluation should be instituted as clinically indicated.
What might happen if I take too much Pre and Post Sx Pouch?
Sorry No Records found
How should I store and handle Pre and Post Sx Pouch?
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from moisture. Keep this and all medication out of the reach of children.Repackaged by Preferred Pharmaceuticals, Inc.Mupirocin Ointment USP, 2% is available as follows:22 g tube (NDC 45802- -22) Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature].*Bactroban Nasal® is a registered trademark of GlaxoSmithKline.Mupirocin Ointment USP, 2% is available as follows:22 g tube (NDC 45802- -22) Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature].*Bactroban Nasal® is a registered trademark of GlaxoSmithKline.Mupirocin Ointment USP, 2% is available as follows:22 g tube (NDC 45802- -22) Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature].*Bactroban Nasal® is a registered trademark of GlaxoSmithKline.Mupirocin Ointment USP, 2% is available as follows:22 g tube (NDC 45802- -22) Store at 20-25°C (68-77°F) [see USP Controlled Room Temperature].*Bactroban Nasal® is a registered trademark of GlaxoSmithKline.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Application of
C-labeled mupirocin ointment to the lower arm of normal male subjects followed by occlusion for 24 hours showed no measurable systemic absorption (<1.1 nanogram mupirocin per milliliter of whole blood). Measurable radioactivity was present in the stratum corneum of these subjects 72 hours after application.
Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite, monic acid, is eliminated by renal excretion, and demonstrates no antibacterial activity. In a trial conducted in 7 healthy adult male subjects, the elimination half-life after intravenous administration of mupirocin was 20 to 40 minutes for mupirocin and 30 to 80 minutes for monic acid. The pharmacokinetics of mupirocin has not been studied in individuals with renal insufficiency.
Non-Clinical Toxicology
This drug is contraindicated in patients with known hypersensitivity to any of the constituents of the product.Avoid contact with the eyes. In case of accidental contact, rinse well with water.
In the event of sensitization or severe local irritation from Mupirocin Ointment USP, 2%, usage should be discontinued.
Clostridium difficile
C. difficile
C. difficile
C. difficile
If CDAD is suspected or confirmed, ongoing antibacterial drug use not directed against may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of , and surgical evaluation should be instituted as clinically indicated.
See .
As with other antibacterial products, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.
Mupirocin Ointment USP, 2% is not formulated for use on mucosal surfaces. Intranasal use has been associated with isolated reports of stinging and drying.
A paraffin-based formulation - *Bactroban Nasal® (mupirocin calcium ointment ) - is available for intranasal use.
Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. In common with other polyethylene glycol-based ointments, Mupirocin Ointment USP, 2% should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment.
Mupirocin Ointment USP, 2% should not be used with intravenous cannulae or at central intravenous sites because of the potential to promote fungal infections and antimicrobial resistance.
The following local adverse reactions have been reported in connection with the use of mupirocin ointment USP, 2%: burning, stinging, or pain in 1.5% of subjects; itching in 1% of subjects; rash, nausea, erythema, dry skin, tenderness, swelling, contact dermatitis, and increased exudate in less than 1% of subjects. Systemic allergic reactions, including anaphylaxis, urticaria, angioedema and generalized rash have been reported in patients treated with mupirocin formulations.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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