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gentamicin sulfate and prednisolone acetate
Overview
What is PRED-G?
What does PRED-G look like?
What are the available doses of PRED-G?
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What should I talk to my health care provider before I take PRED-G?
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How should I use PRED-G?
PRED-G
Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns or penetration of foreign bodies.
The use of a combination drug with an anti-infective component is indicated where the risk of superficial ocular infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
The particular anti-infective drug in this product is active against the following common bacterial eye pathogens:
and
.
A small amount (1/2 inch ribbon) of ointment should be applied in the conjunctival sac one to three times daily. Care should be taken not to discontinue therapy prematurely.
Not more than 8 grams should be prescribed initially and the prescription should not be refilled without further evaluation as outlined in above.
If signs and symptoms fail to improve after two days, the patient should be re-evaluated (see ).
What interacts with PRED-G?
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What are the warnings of PRED-G?
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What are the precautions of PRED-G?
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What are the side effects of PRED-G?
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What should I look out for while using PRED-G?
PRED-G
Prolonged use of corticosteroids may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation. Prolonged use of corticosteroids may suppress the host immune response and thus increase the hazard of secondary ocular infections. Various ocular diseases and long term use of topical corticosteroids have been known to cause corneal and scleral thinning. Use of topical corticosteroids in the presence of thin corneal or scleral tissue may lead to perforation. Acute purulent infections of the eye may be masked or enhanced by the presence of corticosteroid medication.
If these products are used for 10 days or longer, intraocular pressure should be routinely monitored even though it may be difficult in children and uncooperative patients. Steroids should be used with caution in the presence of glaucoma. Intraocular pressure should be checked frequently.
The use of steroids after cataract surgery may delay healing and increase the incidence of bleb formation.
Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex). Employment of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution, frequent slit lamp microscopy is recommended.
What might happen if I take too much PRED-G?
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How should I store and handle PRED-G?
SYLVANT must be refrigerated at 2°C to 8°C (36°F to 46°F). Do not use SYLVANT beyond the expiration date (EXP) located on the carton and the vial.While stored, protect from light. This product contains no preservative.SYLVANT must be refrigerated at 2°C to 8°C (36°F to 46°F). Do not use SYLVANT beyond the expiration date (EXP) located on the carton and the vial.While stored, protect from light. This product contains no preservative.PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11PRED-G3.5g NDC 0023-0066-04Storage:Revised:03/2017©2017 Allergan. All rights reserved.Irvine, CA 92612, U.S.A.All trademarks are the property of their respective owners.Made in the U.S.A. 71725US11
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.
The anti-infective component in
ophthalmic ointment is included to provide action against specific organisms susceptible to it. Gentamicin sulfate is active in vitro against susceptible strains of the following microorganisms:
and
.
When a decision to administer both a corticosteroid and an antimicrobial is made, the administration of such drugs in combination has the advantage of greater patient compliance and convenience, with the added assurance that the appropriate dosage of both drugs is administered. When both types of drugs are in the same formulation, compatibility of ingredients is assured and the correct volume of drug is delivered and retained.
The relative potency of corticosteroids depends on the molecular structure, concentration, and release from the vehicle.
Non-Clinical Toxicology
PRED-GProlonged use of corticosteroids may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation. Prolonged use of corticosteroids may suppress the host immune response and thus increase the hazard of secondary ocular infections. Various ocular diseases and long term use of topical corticosteroids have been known to cause corneal and scleral thinning. Use of topical corticosteroids in the presence of thin corneal or scleral tissue may lead to perforation. Acute purulent infections of the eye may be masked or enhanced by the presence of corticosteroid medication.
If these products are used for 10 days or longer, intraocular pressure should be routinely monitored even though it may be difficult in children and uncooperative patients. Steroids should be used with caution in the presence of glaucoma. Intraocular pressure should be checked frequently.
The use of steroids after cataract surgery may delay healing and increase the incidence of bleb formation.
Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex). Employment of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution, frequent slit lamp microscopy is recommended.
Ocular irritation and punctate keratitis have been associated with the use of ophthalmic ointment. The initial prescription and renewal of the medication order beyond 8 grams should be made by a physician only after examination of the patient’s intraocular pressure, examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining.
As fungal infections of the cornea are particularly prone to develop coincidentally with long term corticosteroid applications, fungal invasion should be suspected in any persistent corneal ulceration where a corticosteroid has been used or is in use. Fungal cultures should be taken when appropriate.
Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available since no denominator of treated patients is available.
The most frequent reactions observed include ocular discomfort, irritation upon instillation of the medication and punctate keratitis. These reactions have resolved upon discontinuation of the medication. Other reactions reported with include eye burning, eye stinging, ocular hyperemia, eye pain, eye discharge, lacrimation increased, eye edema, visual impairment, foreign body sensation in eyes, and dysgeusia. Hypersensitivity including signs and symptoms related to ocular allergy (e.g. conjunctivitis), angioedema (e.g. tongue edema) and allergic skin reactions (e.g. rash and contact allergy) has also been reported.
Reactions occurring most often from the presence of the anti-infective ingredient are allergic sensitizations. The reactions due to the steroid component in decreasing order of frequency are: elevation of intraocular pressure (IOP) with possible development of glaucoma, and infrequent optic nerve damage; posterior subcapsular cataract formation; and delayed wound healing.
Secondary Infection:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
Interactions
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