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PRIMAXIN

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Overview

What is PRIMAXIN?

PRIMAXIN (imipenem and cilastatin) for Injection is a sterile formulation of imipenem, a penem antibacterial, and cilastatin, a renal dehydropeptidase inhibitor with sodium bicarbonate added as a buffer. PRIMAXIN is an antibacterial drug for intravenous administration.

Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by . Its chemical name is (5,6)-3-[[2-(formimidoylamino)ethyl]thio]-6-[()-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. It is an off-white, nonhygroscopic crystalline compound with a molecular weight of 317.37. It is sparingly soluble in water and slightly soluble in methanol. Its empirical formula is CHNOS∙HO, and its structural formula is:

Cilastatin sodium is the sodium salt of a derivatized heptenoic acid. Its chemical name is sodium ()-7[[()-2-amino-2-carboxyethyl]thio]-2-[()-2,2-dimethylcyclopropanecarboxamido]-2-heptenoate. It is an off-white to yellowish-white, hygroscopic, amorphous compound with a molecular weight of 380.43. It is very soluble in water and in methanol. Its empirical formula is CHNOSNa, and its structural formula is:

PRIMAXIN is buffered to provide solutions in the pH range of 6.5 to 8.5. There is no significant change in pH when solutions are prepared and used as directed. PRIMAXIN 500 contains 37.5 mg of sodium (1.6 mEq). Solutions of PRIMAXIN range from colorless to yellow. Variations of color within this range do not affect the potency of the product.



What does PRIMAXIN look like?



What are the available doses of PRIMAXIN?

For Injection: PRIMAXIN is a sterile powder mixture for reconstitution in single-dose containers including vials containing:

What should I talk to my health care provider before I take PRIMAXIN?

How should I use PRIMAXIN?

PRIMAXIN for intravenous use is indicated for the treatment of lower respiratory tract infections caused by susceptible strains of (penicillinase-producing isolates), species, species, , , , species,

For Intravenous Injection Only


What interacts with PRIMAXIN?

Sorry No Records found


What are the warnings of PRIMAXIN?

Sorry No Records found


What are the precautions of PRIMAXIN?

Sorry No Records found


What are the side effects of PRIMAXIN?

Sorry No records found


What should I look out for while using PRIMAXIN?

PRIMAXIN is contraindicated in patients who have shown hypersensitivity to any component of this product.


What might happen if I take too much PRIMAXIN?

In the case of overdosage, discontinue PRIMAXIN, treat symptomatically, and institute supportive measures as required. PRIMAXIN is hemodialyzable.


How should I store and handle PRIMAXIN?

Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102Storage Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided.Manufactured forOceanside Pharmaceuticals, a division ofValeant Pharmaceuticals North America LLCBridgewater, NJ 08807 USAManufactured byValeant Pharmaceuticals International, Inc.Steinbach, MB R5G 1Z7 CanadaVasotecis a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates. All other product/brand names and/or logos are trademarks of their respective owners. © Valeant Pharmaceuticals North America LLC.20001977Rev. 07/20179450102


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

PRIMAXIN is a combination of imipenem and cilastatin. Imipenem is a penem antibacterial drug . Cilastatin sodium is a renal dehydropeptidase inhibitor that limits the renal metabolism of imipenem.

Non-Clinical Toxicology
PRIMAXIN is contraindicated in patients who have shown hypersensitivity to any component of this product.

The interaction of phenazopyridine with other drugs has not been studied in a systematic manner. However, the medical literature to date suggests that no significant interactions have been reported.

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens. There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe hypersensitivity reactions when treated with another beta-lactam. Before initiating therapy with PRIMAXIN, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, other beta-lactams and other allergens. If an allergic reaction to PRIMAXIN occurs, discontinue the drug immediately. Serious anaphylactic reactions require immediate emergency treatment as clinically indicated.

The following serious adverse reactions are described in greater detail in the Warnings and Precautions section.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).