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PROPOXYPHENE HYDROCHLORIDE
Overview
What is PROPOXYPHENE HYDROCHLORIDE?
Propoxyphene Hydrochloride, USP is an odorless, white crystalline powder with a bitter taste. It is freely soluble in water. Chemically, it is (2S,3R)-(+)-4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate (ester) hydrochloride, which can be represented by the accompanying structural formula. Its molecular weight is 375.94.
Each capsule contains 65 mg (172.9 µmol) propoxyphene hydrochloride. It also contains starch NF, magnesium stearate NF, gelatin, titanium dioxide, FD & C Red #40, D & C Red #28 and FD & C Blue #1.
What does PROPOXYPHENE HYDROCHLORIDE look like?
What are the available doses of PROPOXYPHENE HYDROCHLORIDE?
Sorry No records found.
What should I talk to my health care provider before I take PROPOXYPHENE HYDROCHLORIDE?
Sorry No records found
How should I use PROPOXYPHENE HYDROCHLORIDE?
Propoxyphene hydrochloride capsule is indicated for the relief of mild to moderate pain.
Propoxyphene hydrochloride capsule is intended for the management of mild to moderate pain. The dose should be individually adjusted according to severity of pain, patient response and patient size.
Propoxyphene hydrochloride capsule is given orally. The usual dosage is one 65 mg propoxyphene hydrochloride capsule every 4 hours as needed for pain. The maximum dose of propoxyphene hydrochloride capsule is 6 tablets per day.
Patients receiving propoxyphene and any CYP3A4 inhibitor should be carefully monitored for an extended period of time and dosage adjustments should be made if warranted.
Consideration should be given to a reduced total daily dosage in elderly patients and in patients with hepatic or renal impairment.
What interacts with PROPOXYPHENE HYDROCHLORIDE?
Sorry No Records found
What are the warnings of PROPOXYPHENE HYDROCHLORIDE?
Sorry No Records found
What are the precautions of PROPOXYPHENE HYDROCHLORIDE?
Sorry No Records found
What are the side effects of PROPOXYPHENE HYDROCHLORIDE?
Sorry No records found
What should I look out for while using PROPOXYPHENE HYDROCHLORIDE?
Propoxyphene hydrochloride capsule is contraindicated in patients with known hypersensitivity to propoxyphene.
Propoxyphene hydrochloride capsule is contraindicated in patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe asthma or hypercarbia.
Propoxyphene hydrochloride capsule is contraindicated in any patient who has or is suspected of having paralytic ileus.
What might happen if I take too much PROPOXYPHENE HYDROCHLORIDE?
Overdose of propoxyphene hydrochloride capsule may present with the signs and symptoms of propoxyphene overdose. Fatalities within the first hour of overdosage are not uncommon.
In all cases of suspected overdosage, call your regional Poison Control Center to obtain the most up-to-date information about the treatment of overdose. This recommendation is made because, in general, information regarding the treatment of overdosage may change more rapidly than do package inserts.
Initial consideration should be given to the management of the CNS effects of propoxyphene overdosage. Resuscitative measures should be initiated promptly.
Symptoms of Propoxyphene Overdosage
The manifestations of acute overdosage with propoxyphene are those of narcotic overdosage. The patient is usually somnolent but may be stuporous or comatose and convulsing. Respiratory depression is characteristic. The ventilatory rate and/or tidal volume is decreased, which results in cyanosis and hypoxia. Pupils, initially pinpoint, may become dilated as hypoxia increases. Cheyne-Stokes respiration and apnea may occur. Blood pressure and heart rate are usually normal initially, but blood pressure falls and cardiac performance deteriorates, which ultimately results in pulmonary edema and circulatory collapse, unless the respiratory depression is corrected and adequate ventilation is restored promptly. Cardiac arrhythmias and conduction delay may be present. A combined respiratory-metabolic acidosis occurs owing to retained CO2 (hypercapnia) and to lactic acid formed during anaerobic glycolysis. Acidosis may be severe if large amounts of salicylates have also been ingested. Death may occur.
Treatment of Propoxyphene Overdosage
Attention should be directed first to establishing a patent airway and to restoring ventilation. Mechanically assisted ventilation, with or without oxygen, may be required, and positive pressure respiration may be desirable if pulmonary edema is present. The opioid antagonist naloxone will markedly reduce the degree of respiratory depression, and should be administered promptly, preferably intravenously. The duration of action of the antagonist may be brief. If no response is observed after 10 mg of naloxone have been administered, the diagnosis of propoxyphene toxicity should be questioned.
In addition to the use of an opioid antagonist, the patient may require careful titration with an anticonvulsant to control convulsions. Activated charcoal can adsorb a significant amount of ingested propoxyphene. Dialysis is of little value in poisoning due to propoxyphene. Efforts should be made to determine whether other agents, such as alcohol, barbiturates, tranquilizers, or other CNS depressants, were also ingested, since these increase CNS depression as well as cause specific toxic effects or death.
How should I store and handle PROPOXYPHENE HYDROCHLORIDE?
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.Propoxyphene Hydrochloride Capsules, USP 65 mg are bright pink, two piece, hard shell # 3, opaque capsule filled with white powder, imprinted axially “HP” over “12” on each half in edible black ink.They are available as follows:Bottles of 100 NDC 23155-012-01Bottles of 500 NDC 23155-012-05Storage: Store at 20º to 25º C (68° to 77º F) [see USP Controlled Room Temperature]Inform patients of the availability of a Medication Guide for propoxyphene hydrochloride capsule that accompanies each prescription dispensed. Instruct patients to read the propoxyphene hydrochloride capsule Medication Guide prior to using propoxyphene hydrochloride capsule.Manufactured for:Heritage Pharmaceuticals Inc.Edison, NJ 088371.866.901.DRUG (3784)Manufactured by:Amneal Pharmaceuticals, L.L.C.Paterson, NJ 07504Iss. 10/09MEDICATION GUIDEPropoxyphene Hydrochloride Capsule, USPRead this Medication Guide before you start taking propoxyphene hydrochloride capsule, and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Propoxyphene is a centrally acting opiate analgesic. In vitro studies demonstrated propoxyphene and the metabolite norpropoxyphene inhibit sodium channels (local anesthetic effect) with norpropoxyphene being approximately 2-fold more potent than propoxyphene and propoxyphene approximately 10-fold more potent than lidocaine. Propoxyphene and norpropoxyphene inhibit the voltage-gated potassium current carried by cardiac rapidly activating delayed rectifier (hERG) channels with approximately equal potency. It is unclear if the effects on ion channels occur within therapeutic dose range.
Non-Clinical Toxicology
Propoxyphene hydrochloride capsule is contraindicated in patients with known hypersensitivity to propoxyphene.Propoxyphene hydrochloride capsule is contraindicated in patients with significant respiratory depression (in unmonitored settings or the absence of resuscitative equipment) and patients with acute or severe asthma or hypercarbia.
Propoxyphene hydrochloride capsule is contraindicated in any patient who has or is suspected of having paralytic ileus.
Drug Interactions:
Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and tolerance are not unusual during chronic opioid therapy.
The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, myalgia, and mydriasis. Other symptoms also may develop, including: irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate. In general, opioids should not be abruptly discontinued (see ).
If propoxyphene hydrochloride capsule is abruptly discontinued in a physically dependent patient, an abstinence syndrome may occur (see ). If signs and symptoms of withdrawal occur, patients should be treated by reinstitution of opioid therapy followed by gradual tapered dose reduction of propoxyphene hydrochloride capsule combined with symptomatic support (see ).
In hospitalized patients, the most frequently reported were dizziness, sedation, nausea, and vomiting. Other adverse reactions include constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness, euphoria, dysphoria, hallucinations, and minor visual disturbances.
The most frequently reported postmarketing adverse events have included completed suicide, accidental and intentional overdose, drug dependence, cardiac arrest, coma, drug ineffective, drug toxicity, nausea, respiratory arrest, cardio-respiratory arrest, death, vomiting, dizziness, convulsion, confusional state, and diarrhea.
Additional adverse experiences reported through postmarketing surveillance include:
Cardiac disorders:
Eye disorder:
General disorder and administration site conditions:
Gastrointestinal disorder:
Hepatobiliary disorder:
Immune system disorder:
Injury poisoning and procedural complications:
Investigations: blood pressure
Metabolism and nutrition disorder:
Nervous system disorder:
Psychiatric:
Respiratory, thoracic, and mediastinal disorders:
Skin and subcutaneous tissue disorder:
Liver dysfunction has been reported in association with propoxyphene hydrochloride capsule. Propoxyphene therapy has been associated with abnormal liver function tests and, more rarely, with instances of reversible jaundice (including cholestatic jaundice).
Subacute painful myopathy has been reported following chronic propoxyphene overdosage.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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