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PYtest
Overview
What is PYtest?
PYtest (C-Urea Breath Test) is a qualitative and non-invasive method
for the diagnosis of . To detect
C-urea supplied in a capsule is swallowed by the patient. If gastric urease from is present, Urea is split to form CO and NH. Ten minutes after the patient ingests the capsule, a breath sample is collected into a balloon. The breath sample is later transferred to collection fluid to trap the labeled CO. The liquid sample is then analyzed in a liquid scintillation counter.
The PYtest Kit (C-Urea Breath Test) is designed for use with the
PYtest capsule, a gelatin capsule for oral administration containing 1 µCi of C labeled urea. The urea is adsorbed on sugar spheres and colored yellow with fluorescein.
What does PYtest look like?
What are the available doses of PYtest?
Sorry No records found.
What should I talk to my health care provider before I take PYtest?
Sorry No records found
How should I use PYtest?
PYtest (C-Urea Breath Test) is indicated for use in the detection of
gastric urease as an aid in the diagnosis of infection in the
human stomach. The test utilizes a liquid scintillation counter for the
measurement of CO in breath samples.
As shown in Figure 2, the PYtest Kit contains:
Figure 2: PYtest Kit
What interacts with PYtest?
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What are the warnings of PYtest?
Sorry No Records found
What are the precautions of PYtest?
Sorry No Records found
What are the side effects of PYtest?
Sorry No records found
What should I look out for while using PYtest?
None
None
What might happen if I take too much PYtest?
Risk from radiation is negligible even with a 1000 capsule overdose
(0.3 rem). If overdose occurs, the patient may drink one glass of water
(150 mL) every hour to hasten excretion of the isotope. Maximum
excretion of Urea is achieved at a urine output of ≥2.0 mL/min.
How should I store and handle PYtest?
Carton containing two epinephrine injection, USP auto-injectors 0.3 mg: NDC 68788-6376-2.Rx onlyCarton containing two epinephrine injection, USP auto-injectors 0.3 mg: NDC 68788-6376-2.Rx onlyPYtest Kit (C-Urea Breath Test) is supplied as a kit containing a PYtest Capsule, a clear gelatin capsule containing 1µCi of C-urea and breath collection equipment.PYtest Capsules are also supplied separately in unit dose packages of 1,10 and 100.The PYtest Capsule has a shelf life of two years. The expiration date is printed on the capsule label.PYtest Kit (C-Urea Breath Test) is supplied as a kit containing a PYtest Capsule, a clear gelatin capsule containing 1µCi of C-urea and breath collection equipment.PYtest Capsules are also supplied separately in unit dose packages of 1,10 and 100.The PYtest Capsule has a shelf life of two years. The expiration date is printed on the capsule label.PYtest Kit (C-Urea Breath Test) is supplied as a kit containing a PYtest Capsule, a clear gelatin capsule containing 1µCi of C-urea and breath collection equipment.PYtest Capsules are also supplied separately in unit dose packages of 1,10 and 100.The PYtest Capsule has a shelf life of two years. The expiration date is printed on the capsule label.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The urease enzyme is not present in mammalian cells, so the presence
of urease in the stomach is evidence that bacteria are present. The
presence of urease is not specific for , but other bacteria are not
usually found in the stomach. The principle of the breath test is shown
in Figure 1.
Figure 1: Principle of Breath Test
To detect , urea labeled with C is swallowed by the patient.
If gastric urease from is present, urea is split to form CO and
NH at the interface between the gastric epithelium and lumen and
CO is absorbed into the blood and exhaled in the breath.
Following ingestion of the capsule by a patient with , CO
excretion in the breath peaks between 10 and 15 minutes and declines
thereafter with a biological half-life of about 15 minutes. C-urea that
is not hydrolyzed by is excreted in the urine with a half-life of
approximately 12 hours. About 10% of the C remains in the body at
72 hours and is gradually excreted with a biological half-life of 40 days.
Non-Clinical Toxicology
NoneNone
Antibiotics, proton pump inhibitors, sucralfate, and bismuth preparations are known to suppress H.pylori. Ingestion of antibiotics or bismuth within 4 weeks and proton pump inhibitors or sucralfate within 2 weeks prior to performing the test may give false negative results.
After the patient ingests the C-urea capsule, the sample collected for test purposes is for in vitro diagnostic use only.
A false positive test could occur in patients who have achlorhydria. Very rarely, a false positive test may occur due to urease associated with Helicobacters other than (i.e. ).
No adverse reactions were reported in clinical trials.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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