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QUDEXY

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Overview

What is QUDEXY?

Topiramate, USP, is a sulfamate-substituted monosaccharide. QUDEXY XR (topiramate) extended-release capsules are available as 25 mg, 50 mg, 100 mg, 150 mg, and 200 mg capsules for oral administration as whole capsules or opened and sprinkled onto a spoonful of soft food.

Topiramate is a white to off-white powder. Topiramate is freely soluble in polar organic solvents such as acetonitrile and acetone; and very slightly soluble to practically insoluble in non-polar organic solvents such as hexanes. Topiramate has the molecular formula CHNOS and a molecular weight of 339.4. Topiramate is designated chemically as 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate and has the following structural formula:

QUDEXY XR (topiramate) extended-release capsules contain beads of topiramate in a capsule. The inactive ingredients are microcrystalline cellulose, hypromellose 2910, ethylcellulose, diethyl phthalate.

In addition, the capsule shells for all strengths contain hypromellose 2910, titanium dioxide, black iron oxide, red iron oxide and/or yellow iron oxide, black pharmaceutical ink, and white pharmaceutical ink (200 mg only).



What does QUDEXY look like?



What are the available doses of QUDEXY?

Extended-release capsules: 25 mg, 50 mg, 100 mg, 150 mg, and 200 mg ()

What should I talk to my health care provider before I take QUDEXY?

How should I use QUDEXY?

QUDEXY XR extended-release capsules are indicated as initial monotherapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures. Safety and effectiveness in patients who were converted to monotherapy from a previous regimen of other anticonvulsant drugs have not been established in controlled trials .


What interacts with QUDEXY?

Sorry No Records found


What are the warnings of QUDEXY?

Sorry No Records found


What are the precautions of QUDEXY?

Sorry No Records found


What are the side effects of QUDEXY?

Sorry No records found


What should I look out for while using QUDEXY?

QUDEXY XR is contraindicated in patients with metabolic acidosis who are taking concomitant metformin .


What might happen if I take too much QUDEXY?

Overdoses of topiramate have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbance, blurred vision, diplopia, mentation impaired, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after polydrug overdoses involving topiramate.

Topiramate overdose has resulted in severe metabolic acidosis .

A patient who ingested a dose between 96 g and 110 g of topiramate was admitted to hospital with coma lasting 20 to 24 hours followed by full recovery after 3 to 4 days.

Similar signs, symptoms, and clinical consequences are expected to occur with overdosage of QUDEXY XR. Therefore, in acute QUDEXY XR overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb topiramate . Treatment should be appropriately supportive. Hemodialysis is an effective means of removing topiramate from the body.


How should I store and handle QUDEXY?

QUDEXY XR (topiramate) extended-release capsules should be stored in a tightly-closed container at 20 to 25°C (68 to 77°F). Excursions permitted 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Protect from moisture.Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016Naproxen Tablets USP:500 mg:30’s (bottle) : NDC 68462-190-3050’s (bottle) : NDC 68462-190-50100’s (bottle): NDC 68462-190-01500’s (bottle): NDC 68462-190-05NDC single dose pack with 1 tablet as by Avera McKennan HospitalStore at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Naproxen Sodium Tablets USP:275 mg: 100’s (bottle): NDC 68462-178-01500’s (bottle): NDC 68462-178-05550 mg:100’s (bottle): NDC 68462-179-01500’s (bottle): NDC 68462-179-05Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Dispense in well-closed containers.Manufactured by:Glenmark Pharmaceuticals Ltd., INDIAManufactured for:Glenmark Pharmaceuticals Inc., USAQuestions? 1 (888)721-7115www.glenmarkpharma.com/usaMay 2016


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Clinical Information

Chemical Structure

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Clinical Pharmacology

The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV.

Non-Clinical Toxicology
QUDEXY XR is contraindicated in patients with metabolic acidosis who are taking concomitant metformin .

See Table 1 for clinically significant drug interactions with naproxen.

Table 1: Clinically Significant Drug Interactions with naproxen

Drug/Laboratory Test Interactions

A syndrome consisting of acute myopia associated with secondary angle closure glaucoma has been reported in patients receiving topiramate. Symptoms include acute onset of decreased visual acuity and/or ocular pain. Ophthalmologic findings can include myopia, anterior chamber shallowing, ocular hyperemia (redness) and increased intraocular pressure. Mydriasis may or may not be present. This syndrome may be associated with supraciliary effusion resulting in anterior displacement of the lens and iris, with secondary angle closure glaucoma. Symptoms typically occur within 1 month of initiating topiramate therapy. In contrast to primary narrow angle glaucoma, which is rare under 40 years of age, secondary angle closure glaucoma associated with topiramate has been reported in pediatric patients as well as adults. The primary treatment to reverse symptoms is discontinuation of QUDEXY XR as rapidly as possible, according to the judgment of the treating physician. Other measures, in conjunction with discontinuation of QUDEXY XR, may be helpful.

Elevated intraocular pressure of any etiology, if left untreated, can lead to serious sequelae including permanent vision loss.

The following serious adverse reactions are discussed in more detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).