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Qutenza

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Overview

What is Qutenza?

Qutenza (capsaicin) 8% patch contains capsaicin in a localized dermal delivery system. The capsaicin in Qutenza is a synthetic equivalent of the naturally occurring compound found in chili peppers. Capsaicin is soluble in alcohol, acetone, and ethyl acetate and very slightly soluble in water.

Qutenza is a single-use patch stored in a foil pouch. Each Qutenza patch is 14 cm x 20 cm (280 cm) and consists of a polyester backing film coated with a drug-containing silicone adhesive mixture, and covered with a removable polyester release liner.

The backing film is imprinted with "capsaicin 8%". Each Qutenza patch contains a total of 179 mg of capsaicin (8% in adhesive, 80 mg per gram of adhesive) or 640 micrograms (mcg) of capsaicin per square cm of patch.

The empirical formula is CHNO, with a molecular weight of 305.42. The chemical compound capsaicin [(E)-8-methyl-N-vanillyl-6-nonenamide] is an activating ligand for transient receptor potential vanilloid 1 receptor (TRPV1) and it has the following structure:

The patch contains the following inactive ingredients: diethylene glycol monoethyl ether, dimethicone, ethyl cellulose, polyester film, silicone adhesive and white ink.

Qutenza is supplied with a Cleansing Gel which is used to remove residual capsaicin from the skin after treatment. Cleansing Gel consists of the following ingredients: butylated hydroxyanisole, carbomer copolymer, edetate disodium, polyethylene glycol, purified water, and sodium hydroxide.



What does Qutenza look like?



What are the available doses of Qutenza?

Qutenza patch contains 8% capsaicin (640 mcg/cm). Each patch contains a total of 179 mg of capsaicin.

What should I talk to my health care provider before I take Qutenza?

How should I use Qutenza?

Qutenza is indicated for the management of neuropathic pain associated with postherpetic neuralgia.

Only physicians or health care professionals under the close supervision of a physician are to administer Qutenza. ()

Do not use Qutenza on broken skin. ()

Apply Qutenza to the most painful skin areas, using up to four patches. ()

Apply Qutenza for 60 minutes and repeat every 3 months or as warranted by the return of pain (not more frequently than every three months). ()

Use only nitrile (not latex) gloves when handling Qutenza and when cleaning treatment areas. ()

Before patch application, a physician must identify and mark the painful area, including areas of hypersensitivity and allodynia. ()

Apply a topical anesthetic before Qutenza application. ()

Apply Qutenza by placing on the skin while slowly removing the release liner from underneath. ()

Remove the Qutenza patches by gently and slowly rolling them inward. ()

After removal of Qutenza, apply Cleansing Gel for one minute and then remove it with a dry wipe. ()

Treat acute pain during and following the procedure with local cooling and/or analgesics. ()

Dispose of patches and other treatment materials immediately after use in accordance with local biomedical waste procedures. ()

The treated area may be sensitive for a few days to heat (e.g., hot showers/baths, direct sunlight, vigorous exercise). ()


What interacts with Qutenza?

Sorry No Records found


What are the warnings of Qutenza?

Sorry No Records found


What are the precautions of Qutenza?

Sorry No Records found


What are the side effects of Qutenza?

Sorry No records found


What should I look out for while using Qutenza?

None.


What might happen if I take too much Qutenza?

There is no clinical experience with Qutenza overdose in humans.

There is no specific antidote for overdose with capsaicin. In case of suspected overdose, remove patches gently, apply Cleansing Gel for one minute, wipe off with dry gauze and gently wash the area with soap and water. Use supportive measures and treat symptoms as clinically warranted.


How should I store and handle Qutenza?

Qutenza contains capsaicin capable of producing severe irritation of eyes, skin, respiratory tract and mucous membranes. Do not dispense Qutenza to patients for self-administration. It is critical that health care professionals who administer Qutenza have completely familiarized themselves with proper dosing, handling, and disposal procedures before handling Qutenza to avoid accidental or inadvertent capsaicin exposure to themselves or others []. Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012Lovastatin Tablets, USP are available as follows:10 mg — Each white, round, flat faced beveled edge tablet debossed with  on one side and 633 on the other side contains 10 mg of lovastatin, USP.20 mg — Each pink, round, flat faced beveled edge tablet debossed with  on one side and 634 on the other side contains 20 mg of lovastatin, USP.NDC: 35356-885-30  Bottles of 30NDC: 35356-885-60  Bottles of 60NDC: 35356-885-90  Bottles of 9040 mg — Each yellow, round, flat faced beveled edge tablet debossed with  on one side and 635 on the other side contains 40 mg of lovastatin, USP.Dispense in a tight, light-resistant container as defined in the USP.Store between 5° to 25°C (41° to 77°F). Protect from light and store in a well-closed, light-resistant container.Distributed by:Actavis Inc.60 Columbia Rd., Bldg. BMorristown, NJ 07960 USA40-9186Revised - March 2012


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Capsaicin is an agonist for the transient receptor potential vanilloid 1 receptor (TRPV1), which is an ion channel-receptor complex expressed on nociceptive nerve fibers in the skin. Topical administration of capsaicin causes an initial enhanced stimulation of the TRPV1-expressing cutaneous nociceptors that may be associated with painful sensations. This is followed by pain relief thought to be mediated by a reduction in TRPV1-expressing nociceptive nerve endings []. Over the course of several months, there may be a gradual re-emergence of painful neuropathy thought to be due to TRPV1 nerve fiber reinnervation of the treated area.

Non-Clinical Toxicology
None.

Many drugs affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to LEVOXYL. In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and action of other drugs. A listing of drug-thyroidal axis interactions is contained in Table 2.

The list of drug-thyroidal axis interactions in Table 2 may not be comprehensive due to the introduction of new drugs that interact with the thyroidal axis or the discovery of previously unknown interactions. The prescriber should be aware of this fact and should consult appropriate reference sources. (e.g., package inserts of newly approved drugs, medical literature) for additional information if a drug-drug interaction with levothyroxine is suspected.

Do not apply Qutenza to the face or scalp to avoid risk of exposure to the eyes or mucous membranes.

The following serious adverse reactions are discussed elsewhere in the labeling:

Application-Associated Pain [

Increase in Blood Pressure [

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).