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Raloxifene hydrochloride
Overview
What is Raloxifene?
Raloxifene Hydrochloride is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds. The chemical structure is:
The chemical designation is methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride. Raloxifene hydrochloride (HCl) has the empirical formula CHNOS•HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale-yellow solid that is very slightly soluble in water.
Raloxifene hydrochloride is supplied in a tablet dosage form for oral administration. Each raloxifene hydrochloride tablet contains 60 mg of raloxifene HCl, which is the molar equivalent of 55.71 mg of free base. Inactive ingredients include pregelatinized starch, lactose monohydrate, citric acid monohydrate, colloidal silicon dioxide, sodium stearyl fumarate, hypromellose, polysorbate 80, hydroxypropyl methyl cellulose, titanium dioxide, and polyethylene glycol.
What does Raloxifene look like?
What are the available doses of Raloxifene?
Tablets (not scored): 60 mg ()
What should I talk to my health care provider before I take Raloxifene?
How should I use Raloxifene?
Raloxifene Hydrochloride Tablets USP are indicated for the treatment and prevention of osteoporosis in postmenopausal women .
The recommended dosage is one 60 mg raloxifene hydrochloride tablet daily, which may be administered any time of day without regard to meals [].
For the indications in risk of invasive breast cancer the optimum duration of treatment is not known [].
What interacts with Raloxifene?
Sorry No Records found
What are the warnings of Raloxifene?
Sorry No Records found
What are the precautions of Raloxifene?
Sorry No Records found
What are the side effects of Raloxifene?
Sorry No records found
What should I look out for while using Raloxifene?
Active or past history of venous thromboembolism, including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. ()
Pregnancy, women who may become pregnant, and nursing mothers. (, , )
What might happen if I take too much Raloxifene?
In an 8-week study of 63 postmenopausal women, a dose of raloxifene HCl 600 mg/day was safely tolerated. In clinical trials, no raloxifene overdose has been reported.
In postmarketing spontaneous reports, raloxifene overdose has been reported very rarely (less than 1 out of 10,000 [<0.01%] patients treated). The highest overdose has been approximately 1.5 grams. No fatalities associated with raloxifene overdose have been reported. Adverse reactions were reported in approximately half of the adults who took 180 mg raloxifene and included leg cramps and dizziness.
Two 18-month-old children each ingested raloxifene 180 mg. In these two children, symptoms reported included ataxia, dizziness, vomiting, rash, diarrhea, tremor, and flushing, as well as elevation in alkaline phosphatase.
There is no specific antidote for raloxifene.
No mortality was seen after a single oral dose in rats or mice at 5000 mg/kg (810 times the human dose for rats and 405 times the human dose for mice based on surface area, mg/m) or in monkeys at 1000 mg/kg (80 times the AUC in humans).
How should I store and handle Raloxifene?
Store at controlled room temperature, 20º to 25ºC (68º to 77ºF) [ USP]. The USP defines controlled room temperature as a temperature maintained thermostatically that encompasses the usual and customary working environment of 20º to 25ºC (68º to 77ºF); that results in a mean kinetic temperature calculated to be not more than 25ºC; and that allows for excursions between 15º and 30ºC (59º and 86ºF) that are experienced in pharmacies, hospitals, and warehouses.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.Bupropion hydrochloride extended-release tablets, USP (SR), for oral administration, are available as100 mgAquamarine, round, biconvex, film-coated tablets, debossed “” over “410” on one side and plain on the other side and supplied as:NDC 0185-0410-60 bottles of 60NDC 0185-0410-01 bottles of 100NDC 0185-0410-52 bottles of 250NDC 0185-0410-05 bottles of 500150 mgPlum, round, biconvex, film-coated tablets, debossed “” over “415” on one side and plain on the other side and supplied as:NDC 0185-0415-60 bottles of 60NDC 0185-0415-01 bottles of 100NDC 0185-0415-52 bottles of 250NDC 0185-0415-05 bottles of 500200 mgLight pink, round, biconvex, film-coated tablets, debossed “” on one side and debossed “1111” on the other side and supplied as:NDC 0185-1111-60 bottles of 60NDC 0185-1111-01 bottles of 100NDC 0185-1111-52 bottles of 250NDC 0185-1111-05 bottles of 500NDC 0185-1111-10 bottles of 1000Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Dispense contents in a tight, light-resistant container as defined in the USP with a child-resistant closure, as required.Protect from light and moisture. Keep tightly closedKEEP THIS AND ALL MEDICATION OUT OF THE REACH OF CHILDREN.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Raloxifene is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM). The biological actions of raloxifene are largely mediated through binding to estrogen receptors. This binding results in activation of estrogenic pathways in some tissues (agonism) and blockade of estrogenic pathways in others (antagonism). The agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.
Raloxifene appears to act as an estrogen agonist in bone. It decreases bone resorption and bone turnover, increases bone mineral density (BMD) and decreases fracture incidence. Preclinical data demonstrate that raloxifene is an estrogen antagonist in uterine and breast tissues. These results are consistent with findings in clinical trials, which suggest that raloxifene lacks estrogen-like effects on the uterus and breast tissue.
Non-Clinical Toxicology
Active or past history of venous thromboembolism, including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. ()Pregnancy, women who may become pregnant, and nursing mothers. (, , )
In clinical trials, raloxifene-treated women had an increased risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism). Other venous thromboembolic events also could occur. A less serious event, superficial thrombophlebitis, also has been reported more frequently with raloxifene than with placebo. The greatest risk for deep vein thrombosis and pulmonary embolism occurs during the first 4 months of treatment, and the magnitude of risk appears to be similar to the reported risk associated with use of hormone therapy. Because immobilization increases the risk for venous thromboembolic events independent of therapy, raloxifene should be discontinued at least 72 hours prior to and during prolonged immobilization (e.g., post-surgical recovery, prolonged bed rest), and raloxifene therapy should be resumed only after the patient is fully ambulatory. In addition, women taking raloxifene should be advised to move about periodically during prolonged travel. The risk-benefit balance should be considered in women at risk of thromboembolic disease for other reasons, such as congestive heart failure, superficial thrombophlebitis, and active malignancy .
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).