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Repaglinide

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Overview

What is Repaglinide?

Repaglinide is an oral blood glucose-lowering drug of the glinide class. Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl) amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea insulin secretagogues.

Repaglinide USP is a white to off-white solid with molecular formula CHNO and a molecular weight of 452.6. Repaglinide tablets, USP contain 0.5 mg, 1 mg, or 2 mg of repaglinide USP. In addition each tablet contains the following inactive ingredients: anhydrous dibasic calcium phosphate, corn starch, glycerol, magnesium stearate, meglumine, microcrystalline cellulose, polacrillin potassium, poloxamer, and povidone. In addition, the 1 mg tablet contains ferric oxide (Sicovit Yellow 10) and 2 mg tablet contains ferric oxide (Sicovit Red 30).



What does Repaglinide look like?



What are the available doses of Repaglinide?

Tablets: 0.5 mg, 1 mg, 2 mg

What should I talk to my health care provider before I take Repaglinide?

How should I use Repaglinide?

Repaglinide tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Repaglinide tablets should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.

The recommended starting dose for patients whose HbA is less than 8% is 0.5 mg orally before each meal. For patients whose HbA is 8% or greater the starting dose is 1 mg or 2 mg orally before each meal. The recommended dose range is 0.5 mg to 4 mg before meals, with a maximum daily dose of 16 mg. The patient’s dose should be doubled up to 4 mg with each meal until satisfactory glycemic control is achieved. At least one week should elapse to assess response after each dose adjustment. Instruct patients to take repaglinide tablets within 30 minutes before meals. Repaglinide tablets may be dosed 2, 3, or 4 times a day in response to changes in the patient’s meal pattern. In patients who skip meals, instruct patients to skip the scheduled dose of repaglinide tablets to reduce the risk of hypoglycemia. In patients who experience hypoglycemia, the dose of repaglinide tablets should be reduced .


What interacts with Repaglinide?

Sorry No Records found


What are the warnings of Repaglinide?

Sorry No Records found


What are the precautions of Repaglinide?

Sorry No Records found


What are the side effects of Repaglinide?

Sorry No records found


What should I look out for while using Repaglinide?

Repaglinide tablets are contraindicated in patients with:


What might happen if I take too much Repaglinide?

Severe hypoglycemic reactions with coma, seizure, or other neurological impairment may occur and constitute medical emergencies requiring immediate hospitalization. Hypoglycemic symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring may continue until the physician is assured that the patient is out of danger. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery. There is no evidence that repaglinide is dialyzable using hemodialysis.


How should I store and handle Repaglinide?

Repaglinide Tablets USP, 0.5 mgUSP, 1 mgUSP, 2 mgRepaglinide Tablets USP, 0.5 mgUSP, 1 mgUSP, 2 mgRepaglinide Tablets USP, 0.5 mgUSP, 1 mgUSP, 2 mgRepaglinide Tablets USP, 0.5 mgUSP, 1 mgUSP, 2 mg