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RHOFADE

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Overview

What is RHOFADE?

RHOFADE (oxymetazoline hydrochloride) cream 1% contains oxymetazoline hydrochloride, an alpha adrenoceptor agonist. RHOFADE is a white to off-white cream. It has a chemical name of 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-phenol hydrochloride and a molecular weight of 296.8. It is freely soluble in water and ethanol and has a partition coefficient of 0.1 in 1-octanol/water. The molecular formula of oxymetazoline HCl is CHClNO and its structural formula is:

Each gram of RHOFADE (oxymetazoline hydrochloride) cream contains 10 mg (1%) oxymetazoline hydrochloride, equivalent to 8.8 mg (0.88%) of oxymetazoline free base. The cream contains the following inactive ingredients: sodium citrate dihydrate, citric acid anhydrous, disodium edetate dihydrate, butylated hydroxytoluene, anhydrous lanolin, medium chain triglycerides, diisopropyl adipate, oleyl alcohol, polyethylene glycol 300, PEG-6 stearate, glycol stearate, PEG-32 stearate, cetostearyl alcohol, ceteareth-6, stearyl alcohol, ceteareth-25, methylparaben, propylparaben, phenoxyethanol, and purified water.



What does RHOFADE look like?



What are the available doses of RHOFADE?

Cream, 1%. Each gram of cream contains 10 mg (1%) oxymetazoline hydrochloride, equivalent to 8.8 mg (0.88%) of oxymetazoline free base. ()

What should I talk to my health care provider before I take RHOFADE?

How should I use RHOFADE?

RHOFADE™ cream is indicated for the topical treatment of persistent facial erythema associated with rosacea in adults.

For topical use only. RHOFADE is not for oral, ophthalmic, or intravaginal use.

Prime the RHOFADE pump before using for the first time. To do so, with the pump in the upright position, repeatedly depress the actuator until cream is dispensed and then pump three times. Discard the cream from priming actuations. It is only necessary to prime the pump before the first dose.

RHOFADE tubes do not require priming.

Apply a pea-sized amount of RHOFADE cream, once daily in a thin layer to cover the entire face (forehead, nose, each cheek, and chin) avoiding the eyes and lips. Wash hands immediately after applying RHOFADE cream.


What interacts with RHOFADE?

Sorry No Records found


What are the warnings of RHOFADE?

Sorry No Records found


What are the precautions of RHOFADE?

Sorry No Records found


What are the side effects of RHOFADE?

Sorry No records found


What should I look out for while using RHOFADE?

None.


What might happen if I take too much RHOFADE?

RHOFADE is not for oral use. If oral ingestion occurs, seek medical advice. Monitor patient closely and administer appropriate supportive measures as necessary. Accidental ingestion of topical solutions (nasal sprays) containing imidazoline derivatives (e.g., oxymetazoline) in children has resulted in serious adverse events requiring hospitalization, including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence, mydriasis, stupor, hypothermia, drooling, and coma. Keep RHOFADE out of reach of children.


How should I store and handle RHOFADE?

Store at 20 to 25°C (68 to 77°F) [See USP Controlled Room Temperature]. Preserve in tight, light-resistant containers. Protect from moisture.RHOFADENDC 0023-5300-30       30 gram tube NDC 0023-5300-60       60 gram tube NDC 0023-5300-35       30 gram pump NDC 0023-5300-65       60 gram pump RHOFADENDC 0023-5300-30       30 gram tube NDC 0023-5300-60       60 gram tube NDC 0023-5300-35       30 gram pump NDC 0023-5300-65       60 gram pump RHOFADENDC 0023-5300-30       30 gram tube NDC 0023-5300-60       60 gram tube NDC 0023-5300-35       30 gram pump NDC 0023-5300-65       60 gram pump RHOFADENDC 0023-5300-30       30 gram tube NDC 0023-5300-60       60 gram tube NDC 0023-5300-35       30 gram pump NDC 0023-5300-65       60 gram pump RHOFADENDC 0023-5300-30       30 gram tube NDC 0023-5300-60       60 gram tube NDC 0023-5300-35       30 gram pump NDC 0023-5300-65       60 gram pump


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Oxymetazoline is an alpha adrenoceptor agonist. Oxymetazoline acts as a vasoconstrictor.

Non-Clinical Toxicology
None.

See Table 6 for a listing of drugs that may significantly alter voriconazole concentrations. Also, see Table 7 for a listing of drugs that may interact with voriconazole resulting in altered pharmacokinetics or pharmacodynamics of the other drug .

Alpha-adrenergic agonists may impact blood pressure. RHOFADE should be used with caution in patients with severe or unstable or uncontrolled cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension to seek immediate medical care if their condition worsens.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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